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1.发明申请公开(公告)号：US20090136505A1
公开(公告)日：2009-05-28
申请号：US11931201
申请日：2007-10-31
Applicant: Johanna Bentz , Beth Hill , Lisbeth Illum
Inventor： Johanna Bentz , Beth Hill , Lisbeth Illum
IPC: A61K39/395 , A61K38/43
CPC classification number: C07K16/18 , A61K9/0043 , A61K38/34 , A61K38/50 , A61K47/26 , A61K47/28 , A61K47/34 , A61K47/6811 , A61K47/6851 , A61K51/086 , A61K51/088 , C07K14/685 , C07K2319/30
Abstract: Pharmaceutical compositions and methods for delivering a polypeptide to the central nervous system of a mammal via intranasal administration are provided. The polypeptide can be a catalytically active protein or an antibody, antibody fragment or antibody fragment fusion protein. The polypeptides are formulated with one or more specific agents.
Abstract translation: 提供了通过鼻内给药将多肽递送至哺乳动物的中枢神经系统的药物组合物和方法。 多肽可以是催化活性蛋白或抗体，抗体片段或抗体片段融合蛋白。 多肽用一种或多种特异性试剂配制。
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2.发明授权公开(公告)号：US06388868B1
公开(公告)日：2002-05-14
申请号：US09925851
申请日：2001-08-09
Applicant: Brad R. Leccia , Mary Beth Hill
Inventor： Brad R. Leccia , Mary Beth Hill
IPC: H02B1100
CPC classification number: H02B11/133
Abstract: An automatically operating interlock prevents connection of an electrical device within a cabinet unless the cabinet door is closed. The interlock is particularly useful for circuit breakers contained within arc-resistant cabinets. The interlock includes a spring-biased locking plate reciprocating between a locked position wherein the locking plate resists movement of the levering-in locking plate, and an unlocked position wherein the locking plate permits movement of the levering-in locking plate. The locking plate is spring-biased towards its locked position, and is pushed from its locked position to its unlocked position when the cabinet door is closed. Access to the hex drive of the levering-in rod is thereby resisted when the cabinet door is open.
Abstract translation: 自动操作互锁防止机柜内的电气设备连接，除非柜门关闭。 互锁对于防弧柜内包含的断路器特别有用。 互锁包括弹簧偏压的锁定板，其在锁定位置之间往复运动，其中锁定板抵抗杠杆进入锁定板的运动，以及解锁位置，其中锁定板允许杠杆进入锁定板的移动。 锁定板朝向其锁定位置被弹簧偏置，并且当柜门关闭时从其锁定位置推动到其解锁位置。 因此，当柜门打开时，进入杠杆杆的六角形驱动器就被抵抗。
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3.发明授权Non-aqueous high concentration reduced viscosity suspension formulations of antibodies 有权抗体的非水性高浓度降低粘度悬浮液制剂公开(公告)号：US09072668B2
公开(公告)日：2015-07-07
申请号：US13249774
申请日：2011-09-30
Applicant: Weiguo Dai , Beth Hill , Kui Liu , Carl Mieczkowski
Inventor： Weiguo Dai , Beth Hill , Kui Liu , Carl Mieczkowski
IPC: A61K39/395 , A61K39/40 , A61K9/10 , A61K9/00 , A61K9/14 , A61K9/19 , A61K38/38 , A61K47/26 , A61K47/44 , C07K16/24
CPC classification number: A61K9/10 , A61K9/0019 , A61K9/145 , A61K9/19 , A61K38/38 , A61K39/39591 , A61K47/26 , A61K47/44 , C07K16/241
Abstract: The present invention relates to non-aqueous high concentration reduced viscosity suspension formulations of antibodies and methods of making and using them.
Abstract translation: 本发明涉及抗体的非水性高浓度还原粘度悬浮液制剂及其制备和使用方法。
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4.发明申请公开(公告)号：US20110223208A1
公开(公告)日：2011-09-15
申请号：US13043925
申请日：2011-03-09
Applicant: Beth Hill , Weiguo Dai
Inventor： Beth Hill , Weiguo Dai
CPC classification number: A61K9/10 , A61K9/0019 , A61K9/145 , A61K9/19 , A61K38/38 , A61K39/00 , A61K47/26 , A61K47/42 , A61K47/44 , C07K16/00
Abstract: The present invention relates to non-aqueous high concentration reduced viscosity suspension formulations and methods of making and using them.
Abstract translation: 本发明涉及非水性高浓度还原粘度悬浮液制剂及其制备和使用方法。
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Patent Agency Ranking
公开(公告)号：US20070015701A1
公开(公告)日：2007-01-18
申请号：US11444598
申请日：2006-05-31
Applicant: Samuel Zalipsky , Francis Farrell , Beth Hill , Radwan Kiwan
Inventor： Samuel Zalipsky , Francis Farrell , Beth Hill , Radwan Kiwan
IPC: A61K38/18
CPC classification number: A61K38/1875 , A61K47/60
Abstract: A modified bone morphogenetic protein (BMP, also referred to as bone morphogenic protein) composition is described. The bone morphogenetic protein, in one embodiment, is BMP-7 which is chemically modified with a hydrophilic polymer, such as poly(ethylene glycol).
Abstract translation: 描述了修饰的骨形态发生蛋白（BMP，也称为骨形态发生蛋白）组合物。 在一个实施方案中，骨形态发生蛋白是BMP-7，其用亲水性聚合物如聚（乙二醇）化学改性。
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6.发明申请公开(公告)号：US20060188496A1
公开(公告)日：2006-08-24
申请号：US11342058
申请日：2006-01-27
Applicant: Hanne Bentz , Beth Hill , Catherine Lucas , William Frey
Inventor： Hanne Bentz , Beth Hill , Catherine Lucas , William Frey
IPC: A61K38/17 , A61K39/395
CPC classification number: A61K38/34 , A61K9/0043 , A61K47/6811 , A61K51/08 , A61K51/086 , C07K2319/30
Abstract: A method for delivering a polypeptide to the central nervous system of a mammal is provided. The method involves attaching the polypeptide to an antibody or an antibody fragment and administering the fusion polypeptide intranasally, for delivery to the central nervous system. Methods of treatment are also provided, where a therapeutically effective amount of the composition is delivered to the nasal cavity of a mammal.
Abstract translation: 提供了将多肽递送至哺乳动物的中枢神经系统的方法。 该方法包括将多肽连接到抗体或抗体片段，并将鼻内融合多肽施用于递送至中枢神经系统。 还提供了治疗方法，其中将治疗有效量的组合物递送至哺乳动物的鼻腔。
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公开(公告)号：US20060030526A1
公开(公告)日：2006-02-09
申请号：US11194850
申请日：2005-08-01
Applicant: Kui Liu , Michael Desjardin , Beth Hill , Zengji Li
Inventor： Kui Liu , Michael Desjardin , Beth Hill , Zengji Li
IPC: A61K38/18 , A61K31/7012
CPC classification number: A61K9/0004 , A61K9/0024 , A61K9/10 , A61K9/1623 , A61K38/1816 , A61K47/32
Abstract: A suspension formulation for therapeutic use includes a non-aqueous, single-phase vehicle exhibiting viscous fluid characteristics and a particle formulation comprising an erythropoietin receptor agonist dispersed in the vehicle.
Abstract translation: 用于治疗用途的悬浮液制剂包括显示粘性流体特性的非水性单相载体和包含分散在载体中的促红细胞生成素受体激动剂的颗粒制剂。
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公开(公告)号：US06746092B2
公开(公告)日：2004-06-08
申请号：US10074963
申请日：2002-02-13
Applicant: Brad R. Leccia , Mary Beth Hill
Inventor： Brad R. Leccia , Mary Beth Hill
IPC: E05C706
CPC classification number: H02B1/38 , Y10T292/42
Abstract: A switchgear cabinet includes a plurality of securing apparatuses that are mounted on a vertical flange of the switchgear cabinet, with the securing apparatuses each being formed with a locking hole that is engageable by a pin of a locking mechanism on a door member. Each securing apparatus includes an anchor plate connected with a first bracket and a second bracket, with the first and second brackets being mounted on the flange of the switchgear cabinet. The locking hole is formed in the anchor plate, and the anchor plate is substantially planar and free of bends. The anchor plate further is generally U-shaped and is configured to extend generally around at least a portion of the flange.
Abstract translation: 开关柜包括安装在开关柜的垂直凸缘上的多个固定装置，每个固定装置都形成有可由门构件上的锁定机构的销接合的锁定孔。 每个固定装置包括与第一支架和第二支架连接的锚板，其中第一和第二支架安装在开关柜的凸缘上。 锁定孔形成在锚板中，并且锚板基本上是平面的并且没有弯曲部。 锚定板还通常为U形并且构造成大致围绕凸缘的至少一部分延伸。
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9.发明申请公开(公告)号：US20120076800A1
公开(公告)日：2012-03-29
申请号：US13249774
申请日：2011-09-30
Applicant: Weiguo Dai , Beth Hill , Kui Liu , Carl Mieczkowski
Inventor： Weiguo Dai , Beth Hill , Kui Liu , Carl Mieczkowski
IPC: A61K39/395
CPC classification number: A61K9/10 , A61K9/0019 , A61K9/145 , A61K9/19 , A61K38/38 , A61K39/39591 , A61K47/26 , A61K47/44 , C07K16/241
Abstract: The present invention relates to non-aqueous high concentration reduced viscosity suspension formulations of antibodies and methods of making and using them.
Abstract translation: 本发明涉及抗体的非水性高浓度还原粘度悬浮液制剂及其制备和使用方法。
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