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公开(公告)号：US08222291B2
公开(公告)日：2012-07-17
申请号：US12897760
申请日：2010-10-04
IPC分类号： A61K31/40 , C07D207/04
CPC分类号： C07D207/16 , C07D249/04 , C07D403/06 , C07D403/10 , C07D403/14 , C07D487/14
摘要： The invention provides small molecule mimics of the Smac peptide that are dimer- or dimer-like compounds having two amide-containing domains connected by a linker. These compounds are useful to promote apoptosis. The invention includes pharmaceutical compositions comprising such compounds and methods to use them to treat conditions including cancer and autoimmune disorders.
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公开(公告)号：US08586542B2
公开(公告)日：2013-11-19
申请号：US13536974
申请日：2012-06-28
IPC分类号： A61K38/00
CPC分类号： C07D207/16 , C07D249/04 , C07D403/06 , C07D403/10 , C07D403/14 , C07D487/14
摘要： The invention provides small molecule mimics of the Smac peptide that are dimer- or dimer-like compounds having two amide-containing domains connected by a linker. These compounds are useful to promote apoptosis. The invention includes pharmaceutical compositions comprising such compounds and methods to use them to treat conditions including cancer and autoimmune disorders.
摘要翻译： 本发明提供Smac肽的小分子模拟物，其是具有通过接头连接的两个含酰胺的结构域的二聚体或二聚体样化合物。 这些化合物可用于促进凋亡。 本发明包括包含这些化合物的药物组合物和使用它们来治疗包括癌症和自身免疫疾病的病症的方法。
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3.发明授权公开(公告)号：US07807699B2
公开(公告)日：2010-10-05
申请号：US11726602
申请日：2007-03-21
IPC分类号： A01N43/64
CPC分类号： C07D207/16 , C07D249/04 , C07D403/06 , C07D403/10 , C07D403/14 , C07D487/14
摘要： The invention provides small molecule mimics of the Smac peptide that are dimer- or dimer-like compounds having two amide-containing domains connected by a linker. These compounds are useful to promote apoptosis. The invention includes pharmaceutical compositions comprising such compounds and methods to use them to treat conditions including cancer and autoimmune disorders.
摘要翻译： 本发明提供Smac肽的小分子模拟物，其是具有通过接头连接的两个含酰胺的结构域的二聚体或二聚体样化合物。 这些化合物可用于促进凋亡。 本发明包括包含这些化合物的药物组合物和使用它们来治疗包括癌症和自身免疫疾病的病症的方法。
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公开(公告)号：US20120082640A1
公开(公告)日：2012-04-05
申请号：US12897760
申请日：2010-10-04
IPC分类号： A61K31/40 , A61K31/551 , A61K31/4192 , A61P37/00 , C07D487/14 , A61K31/4985 , A61P35/04 , C07D401/12 , C07D249/04
CPC分类号： C07D207/16 , C07D249/04 , C07D403/06 , C07D403/10 , C07D403/14 , C07D487/14
摘要： The invention provides small molecule mimics of the Smac peptide that are dimer- or dimer-like compounds having two amide-containing domains connected by a linker. These compounds are useful to promote apoptosis. The invention includes pharmaceutical compositions comprising such compounds and methods to use them to treat conditions including cancer and autoimmune disorders.
摘要翻译： 本发明提供Smac肽的小分子模拟物，其是具有通过接头连接的两个含酰胺的结构域的二聚体或二聚体样化合物。 这些化合物可用于促进凋亡。 本发明包括包含这些化合物的药物组合物和使用它们来治疗包括癌症和自身免疫疾病的病症的方法。
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公开(公告)号：US20080051389A1
公开(公告)日：2008-02-28
申请号：US11726602
申请日：2007-03-21
申请人： Gunnar Hanson , David Thomas , Nizal Chandrakumar , Susan Harran
发明人： Gunnar Hanson , David Thomas , Nizal Chandrakumar , Susan Harran
IPC分类号： A61K31/4025 , A61K31/4192 , A61K31/551 , A61P29/00 , A61P35/00 , A61P37/00 , C07D403/06 , C07D403/10 , C07D403/14 , C07D487/14
CPC分类号： C07D207/16 , C07D249/04 , C07D403/06 , C07D403/10 , C07D403/14 , C07D487/14
摘要： The invention provides small molecule mimics of the Smac peptide that are dimer- or dimer-like compounds having two amide-containing domains connected by a linker. These compounds are useful to promote apoptosis. The invention includes pharmaceutical compositions comprising such compounds and methods to use them to treat conditions including cancer and autoimmune disorders.
摘要翻译： 本发明提供Smac肽的小分子模拟物，其是具有通过接头连接的两个含酰胺的结构域的二聚体或二聚体样化合物。 这些化合物可用于促进凋亡。 本发明包括包含这些化合物的药物组合物和使用它们来治疗包括癌症和自身免疫疾病的病症的方法。
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公开(公告)号：US10827309B2
公开(公告)日：2020-11-03
申请号：US16518277
申请日：2019-07-22
申请人： David Thomas
发明人： David Thomas
摘要： A method for receiving an emergency communication includes receiving a first portion of a first communication. The method also includes receiving a second portion of a second communication. The second communication may be a duplicate of the first communication. The method includes reconstructing the first communication using the first portion and the second portion.
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7.发明授权公开(公告)号：US09247279B2
公开(公告)日：2016-01-26
申请号：US14087254
申请日：2013-11-22
申请人： Brett Bleacher , Andrew Musgrave , David Thomas , Simon Gresham
发明人： Brett Bleacher , Andrew Musgrave , David Thomas , Simon Gresham
IPC分类号： H04N7/18 , H02B1/00 , H05K7/16 , H05K5/00 , H04N21/414 , H04N21/422 , H04N21/443
CPC分类号： H04N21/41422 , H04N21/2146 , H04N21/26258 , H04N21/41407 , H04N21/422 , H04N21/4436 , H04N21/6405
摘要： A portable entertainment system for a vehicle includes a portable housing, a transceiver, a processor, a memory, and a rechargeable battery. The transceiver communicates through RF signals with Portable Electronic Devices (PEDs) operated by vehicle passengers. The rechargeable battery supplies power to the transceiver, the processor, and the memory. The memory is coupled to the processor and includes entertainment content and further includes computer readable program code that causes the processor to communicate a list, of at least some of the entertainment content available in the memory, to the PEDs. A content selection message is received through the transceiver from one of the PEDs that requests communication of a selected one of the entertainment content identified in the list. The selected entertainment content is communicated through the transceiver to the PED. The transceiver, the processor, and the memory are enclosed within the portable housing.
摘要翻译： 一种用于车辆的便携式娱乐系统包括便携式外壳，收发器，处理器，存储器和可充电电池。 收发器通过RF信号与车载乘客操作的便携式电子设备（PED）进行通信。 可充电电池为收发器，处理器和存储器供电。 存储器耦合到处理器并且包括娱乐内容，并且还包括使处理器将存储器中可用的至少一些娱乐内容的列表传达给PED的计算机可读程序代码。 通过收发器从其中一个PED接收到内容选择消息，该PED请求在列表中标识的娱乐内容中选择的一个娱乐内容的通信。 所选择的娱乐内容通过收发器传送到PED。 收发器，处理器和存储器被封装在便携式外壳内。
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公开(公告)号：US20150136190A1
公开(公告)日：2015-05-21
申请号：US14541489
申请日：2014-11-14
申请人： David Thomas
发明人： David Thomas
CPC分类号： A61H3/00 , A61H3/04 , A61H2201/0161 , A61H2201/0192
摘要： An adjustable walking frame design for walking aid device is provided. The adjustable walking frame has a pair of beam assemblies where the pair of beam assemblies is pivotally mounted to each other. The pivotal mounting provides flexible angle adjustment between the pair of beam assemblies. The height and width of the beam assemblies can be adjusted to meet individual's physical measurements. The adjustable walking frame can be collapsed to occupy minimal space when the adjustable walking frame is stored or transported.
摘要翻译： 提供了一种用于助行器的可调式步行架设计。 可调节步行架具有一对梁组件，其中一对梁组件相互枢转地安装。 枢转安装在一对梁组件之间提供灵活的角度调节。 可以调节梁组件的高度和宽度，以满足个人的物理测量。 当可调节的步行架被储存或运输时，可调节的行走架可以折叠以占用最小的空间。
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9.发明申请公开(公告)号：US20120306128A1
公开(公告)日：2012-12-06
申请号：US13512115
申请日：2010-11-26
申请人： John L. Parker , David Robinson , David Thomas , Mark Fretz
发明人： John L. Parker , David Robinson , David Thomas , Mark Fretz
IPC分类号： C04B35/64
CPC分类号： A61N1/3754 , A61N1/3756 , B22F3/225 , B28B1/24 , B29C33/302 , B29C45/0001 , C04B2111/00137 , C04B2235/6022
摘要： Methods of forming feedthroughs for hermetically sealed housings using powder injection molding, including positioning a plurality of separate electrically conductive elements in a mold, injecting non-electrically conductive powder injection molding (PIM) feedstock into the mold to form a plurality of insulative bodies around the conductive elements, sintering the insulative bodies to form the plurality of feedthroughs physically connected to one another via the conductive elements; and severing the conductive elements between neighboring insulative bodies.
摘要翻译： 使用粉末注射成型形成用于密封壳体的馈通件的方法，包括在模具中定位多个单独的导电元件，将非导电粉末注射成型（PIM）原料注入模具中，以在多个绝缘体周围形成多个绝缘体 导电元件，烧结绝缘体以形成通过导电元件彼此物理连接的多个馈通; 并切断相邻绝缘体之间的导电元件。
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公开(公告)号：US08175375B2
公开(公告)日：2012-05-08
申请号：US10334825
申请日：2002-12-29
申请人： Christophe Bonnery , Jean-Yves Desbree , Chrisophe Flouzat , Daniel Le Guennec , David Mercier , Mickaël Remingol , Renaud Seguier , David Thomas , Gilles Vaucher
发明人： Christophe Bonnery , Jean-Yves Desbree , Chrisophe Flouzat , Daniel Le Guennec , David Mercier , Mickaël Remingol , Renaud Seguier , David Thomas , Gilles Vaucher
IPC分类号： G06K9/62
CPC分类号： H04N19/103 , H04N19/12 , H04N19/147 , H04N19/154 , H04N19/67 , H04N19/89 , H04N19/94
摘要： A method of compression of videotelephony images characterized by: creating (10) a learning base containing images; centering the learning base about zero; determining component images by principal component analysis (12); and keeping a number of significant principal components (14).
摘要翻译： 一种压缩视频电话图像的方法，其特征在于：创建（10）包含图像的学习基础; 以学习基础为中心为零; 通过主成分分析确定分量图像（12）; 并保留一些重要的主要组成部分（14）。
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