公开(公告)号：US07361468B2

公开(公告)日：2008-04-22

申请号：US11175859

申请日：2005-07-05

申请人： Guoying Liu ,  Simon Cawley ,  Hajime Matsuzaki ,  Earl A. Hubbell ,  Geoffrey Yang ,  Teresa A. Webster ,  Rui Mei ,  Xiaojun Di ,  Richard Chiles

发明人： Guoying Liu ,  Simon Cawley ,  Hajime Matsuzaki ,  Earl A. Hubbell ,  Geoffrey Yang ,  Teresa A. Webster ,  Rui Mei ,  Xiaojun Di ,  Richard Chiles

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12M3/00 ,  C12M1/34

CPC分类号： C12Q1/6883 ,  C12Q2600/156

摘要： Methods, kits and arrays of nucleic acid probes for genotyping large numbers of human SNPs in parallel are provided. A set of more than 100,000 human SNPs, known to be biallelic in at least two populations is provided. Allele specific perfect match probes and genotyping probe sets are provided for each allele of each biallelic SNP in a set of human SNPs that is useful for genetic analysis within and across populations. Probe sets that include perfect match and mismatch probes are provided. The probe sets are suitable for inclusion in an array. The invention provides the SNP and surrounding sequence and provides the sequences in such a way as to make them available for a variety of analyses including genotyping. As such, the invention relates to diverse fields impacted by the nature of genetics, including biology, medicine, and medical diagnostics.

摘要翻译： 提供了用于并行分析大量人类SNP的核酸探针的方法，试剂盒和阵列。 提供了一组超过100,000个人类SNP，已知在至少两个人群中是双向的。 为一组人类SNP中的每个双重性SNP的每个等位基因提供等位基因特异性完全匹配探针和基因分型探针组，其可用于群体内和跨群体的遗传分析。 提供包括完美匹配和不匹配探针的探针组。 探头组适合包含在阵列中。 本发明提供了SNP和周围序列，并提供了这样的序列，使得它们可用于各种分析，包括基因分型。 因此，本发明涉及受遗传学性质影响的不同领域，包括生物学，医学和医学诊断。

公开(公告)号：US20060024715A1

公开(公告)日：2006-02-02

申请号：US11175859

申请日：2005-07-05

申请人： Guoying Liu ,  Simon Cawley ,  Hajime Matsuzaki ,  Earl Hubbell ,  Geoffrey Yang ,  Teresa Webster ,  Rui Mei ,  Xiaojun Di ,  Richard Chiles

发明人： Guoying Liu ,  Simon Cawley ,  Hajime Matsuzaki ,  Earl Hubbell ,  Geoffrey Yang ,  Teresa Webster ,  Rui Mei ,  Xiaojun Di ,  Richard Chiles

IPC分类号： C12Q1/68 ,  C12M1/34

CPC分类号： C12Q1/6883 ,  C12Q2600/156

摘要： Methods, kits and arrays of nucleic acid probes for genotyping large numbers of human SNPs in parallel are provided. A set of more than 100,000 human SNPs, known to be biallelic in at least two populations is provided. Allele specific perfect match probes and genotyping probe sets are provided for each allele of each biallelic SNP in a set of human SNPs that is useful for genetic analysis within and across populations. Probe sets that include perfect match and mismatch probes are provided. The probe sets are suitable for inclusion in an array. The invention provides the SNP and surrounding sequence and provides the sequences in such a way as to make them available for a variety of analyses including genotyping. As such, the invention relates to diverse fields impacted by the nature of genetics, including biology, medicine, and medical diagnostics.

摘要翻译： 提供了用于并行分析大量人类SNP的核酸探针的方法，试剂盒和阵列。 提供了一组超过100,000个人类SNP，已知在至少两个人群中是双向的。 为一组人类SNP中的每个双重性SNP的每个等位基因提供等位基因特异性完全匹配探针和基因分型探针组，其可用于群体内和跨群体的遗传分析。 提供包括完美匹配和不匹配探针的探针组。 探头组适合包含在阵列中。 本发明提供了SNP和周围序列，并提供了这样的序列，使得它们可用于各种分析，包括基因分型。 因此，本发明涉及受遗传学性质影响的不同领域，包括生物学，医学和医学诊断。

公开(公告)号：US20050123971A1

公开(公告)日：2005-06-09

申请号：US10986963

申请日：2004-11-12

申请人： Xiaojun Di ,  Teresa Webster ,  Daniel Bartell ,  Richard Chiles

发明人： Xiaojun Di ,  Teresa Webster ,  Daniel Bartell ,  Richard Chiles

IPC分类号： C12Q1/68 ,  G01N33/48 ,  G01N33/50 ,  G06F19/00

CPC分类号： C12Q1/6827 ,  G16B20/00 ,  G16B25/00 ,  G16B40/00 ,  C12Q2565/501

摘要： A method for calling the genotype of a sample is described comprising the acts of receiving emission data for one or more target sequences each hybridized to a plurality of probe sets, where each of the probe sets comprises a plurality of probe features; calculating a set of values for each of the probe sets associated with each target sequence; selecting one of the set of values for each of the probe sets associated with each target sequence, wherein the value is selected if it is greater than a reference value; determining a significance value from the selected values of all the probe sets associated with each target sequence; and producing a genotype call for each target sequence based upon the significance value.

摘要翻译： 描述了用于调用样本的基因型的方法，其包括接收与多个探针组杂交的一个或多个靶序列的发射数据的动作，其中每个探针组包括多个探针特征; 计算与每个目标序列相关联的每个探针组的值集合; 为与每个目标序列相关联的每个探针组选择所述一组值中的一个，其中如果所述值大于参考值则选择该值; 从与每个目标序列相关联的所有探针组的选定值中确定显着值; 并根据显着性值对每个靶序列产生基因型调用。

公开(公告)号：US20140149569A1

公开(公告)日：2014-05-29

申请号：US13685639

申请日：2012-11-26

申请人： Andreas Wittenstein ,  Mike Eynon ,  Rakesh Nair ,  Richard Chiles ,  Brian Campbell

发明人： Andreas Wittenstein ,  Mike Eynon ,  Rakesh Nair ,  Richard Chiles ,  Brian Campbell

IPC分类号： H04L29/08

CPC分类号： H04L43/12 ,  H04L41/12 ,  H04L43/028 ,  H04L43/106

摘要： Methods and devices for correlative monitoring, analysis, and control of multi-service, multi-network systems are provided herein. Exemplary methods may include generating a network topology graph of a metanetwork using traffic records obtained from the metanetwork, generating a causal digraph of the metanetwork using the traffic records and the network topology graph, and transmitting one or more of the network topology graph and the causal digraph to a computing system.

摘要翻译： 本文提供了多业务多网络系统相关监控，分析和控制的方法和设备。 示例性方法可以包括使用从元网络获得的业务记录来生成元网络的网络拓扑图，使用业务记录和网络拓扑图生成元网络的因果有向图，并且发送网络拓扑图和因果关系中的一个或多个 有向图到计算系统。