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公开(公告)号：US07960415B2
公开(公告)日：2011-06-14
申请号：US12140497
申请日：2008-06-17
申请人： Guy Brenchley , Jean-Damien Charrier , Steven Durrant , Ronald Knegtel , Michael Mortimore , John Studley
发明人： Guy Brenchley , Jean-Damien Charrier , Steven Durrant , Ronald Knegtel , Michael Mortimore , John Studley
IPC分类号： A61K31/44 , C07D211/72
CPC分类号： C07D213/75 , C07D213/82 , C07D405/12 , C07D417/12
摘要： The present invention provides a compound of formula I: wherein R1, R2, R3, R4, and R5 are as defined herein. The present invention also provides pharmaceutical compositions and methods using such compositions for treating a caspase-mediated diseases and processes for preparing the compounds of the invention.
摘要翻译： 本发明提供式I化合物：其中R 1，R 2，R 3，R 4和R 5如本文所定义。 本发明还提供了使用这种组合物治疗半胱天冬酶介导的疾病的药物组合物和方法以及制备本发明化合物的方法。
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![5-cyano-4-(pyrrolo [2,3B] pyridine-3-yl)-pyrimidine derivatives useful as protein kinase inhibitors](/abs-image/US/2013/09/10/US08530489B2/abs.jpg.150x150.jpg)
2.发明授权5-cyano-4-(pyrrolo [2,3B] pyridine-3-yl)-pyrimidine derivatives useful as protein kinase inhibitors 有权可用作蛋白激酶抑制剂的5-氰基-4-（吡咯并[2,3B]吡啶-3-基） - 嘧啶衍生物公开(公告)号：US08530489B2
公开(公告)日：2013-09-10
申请号：US13477663
申请日：2012-05-22
申请人： Michael Mortimore , Stephen Clinton Young , Simon Robert Lorrie Everitt , Ronald Knegtel , Joanne Louise Pinder , Alistair Peter Rutherford , Steven Durrant , Guy Brenchley , Jean-Damien Charrier , Michael O'Donnell
发明人： Michael Mortimore , Stephen Clinton Young , Simon Robert Lorrie Everitt , Ronald Knegtel , Joanne Louise Pinder , Alistair Peter Rutherford , Steven Durrant , Guy Brenchley , Jean-Damien Charrier , Michael O'Donnell
IPC分类号： A01N43/54 , A61K31/505
CPC分类号： C07D471/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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![5-CYANO-4- (PYRROLO [2,3B] PYRIDINE-3-YL) -PYRIMIDINE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS](/abs-image/US/2012/12/06/US20120309963A1/abs.jpg.150x150.jpg)
3.发明申请5-CYANO-4- (PYRROLO [2,3B] PYRIDINE-3-YL) -PYRIMIDINE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS 有权5-氰基-4-（吡咯并[2,3B]吡啶-3-基） - 吡啶衍生物，用作蛋白激酶抑制剂公开(公告)号：US20120309963A1
公开(公告)日：2012-12-06
申请号：US13477663
申请日：2012-05-22
申请人： Michael Mortimore , Stephen Clinton Young , Simon Robert Lorrie Everitt , Ronald Knegtel , Joanne Louise Pinder , Alistair Peter Rutherford , Steven Durrant , Guy Brenchley , Jean-Damien Charrier , Michael O'Donnell
发明人： Michael Mortimore , Stephen Clinton Young , Simon Robert Lorrie Everitt , Ronald Knegtel , Joanne Louise Pinder , Alistair Peter Rutherford , Steven Durrant , Guy Brenchley , Jean-Damien Charrier , Michael O'Donnell
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US20090093416A1
公开(公告)日：2009-04-09
申请号：US12140497
申请日：2008-06-17
申请人： Guy Brenchley , Jean-Damien Charrier , Steven Durrant , Ronald Knegtel , Michael Mortimore , John R. Studley
发明人： Guy Brenchley , Jean-Damien Charrier , Steven Durrant , Ronald Knegtel , Michael Mortimore , John R. Studley
CPC分类号： C07D213/75 , C07D213/82 , C07D405/12 , C07D417/12
摘要： The present invention provides a compound of formula I: wherein R1, R2, R3, R4, and R5 are as defined herein. The present invention also provides pharmaceutical compositions and methods using such compositions for treating a caspase-mediated diseases and processes for preparing the compounds of the invention.
摘要翻译： 本发明提供式I化合物：其中R 1，R 2，R 3，R 4和R 5如本文所定义。 本发明还提供了使用这种组合物治疗半胱天冬酶介导的疾病的药物组合物和方法以及制备本发明化合物的方法。
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公开(公告)号：US08399458B2
公开(公告)日：2013-03-19
申请号：US12903390
申请日：2010-10-13
IPC分类号： C07D495/04 , C07D513/04 , C07D519/00 , A61K31/4188 , A61K31/4184 , A61K31/55
CPC分类号： C07D513/04 , A61K31/55 , A61K31/551 , A61K45/06 , C07D495/04 , C07D519/00 , C07K14/81
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US07786130B2
公开(公告)日：2010-08-31
申请号：US11511086
申请日：2006-08-28
申请人： Jean-Damien Charrier , Sharn Ramaya , Steven Durrant , Juan-Miguel Jimenez , Guy Brenchley , Ronald Knegtel , Michael Mortimore
发明人： Jean-Damien Charrier , Sharn Ramaya , Steven Durrant , Juan-Miguel Jimenez , Guy Brenchley , Ronald Knegtel , Michael Mortimore
IPC分类号： C07D401/04 , A61K31/44
CPC分类号： C07D213/64 , C07D401/14 , C07D417/14
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
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公开(公告)号：US20090281082A1
公开(公告)日：2009-11-12
申请号：US12466420
申请日：2009-05-15
IPC分类号： A61K31/55 , C07D495/02 , C07D513/04 , A61K31/5513 , A61P35/02 , A61P35/00 , C12N9/99
CPC分类号： C07D513/04 , A61K31/55 , A61K31/551 , A61K45/06 , C07D495/04 , C07D519/00 , C07K14/81
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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![5-cyano-4-(pyrrolo [2,3B] pyridine-3-yl)-pyrimidine derivatives useful as protein kinase inhibitors](/abs-image/US/2012/08/21/US08247421B2/abs.jpg.150x150.jpg)
8.发明授权5-cyano-4-(pyrrolo [2,3B] pyridine-3-yl)-pyrimidine derivatives useful as protein kinase inhibitors 失效可用作蛋白激酶抑制剂的5-氰基-4-（吡咯并[2,3B]吡啶-3-基） - 嘧啶衍生物公开(公告)号：US08247421B2
公开(公告)日：2012-08-21
申请号：US12448489
申请日：2007-12-21
申请人： Michael Mortimore , Stephen Clinton Young , Simon Robert Lorrie Everitt , Ronald Knegtel , Joanne Louise Pinder , Alistair Peter Rutherford , Steven Durrant , Guy Brenchley , Jean-Damien Charrier , Michael O'Donnell
发明人： Michael Mortimore , Stephen Clinton Young , Simon Robert Lorrie Everitt , Ronald Knegtel , Joanne Louise Pinder , Alistair Peter Rutherford , Steven Durrant , Guy Brenchley , Jean-Damien Charrier , Michael O'Donnell
IPC分类号： A01N43/54
CPC分类号： C07D471/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US20120028965A1
公开(公告)日：2012-02-02
申请号：US12903390
申请日：2010-10-13
IPC分类号： A61K31/551 , A61P35/00 , A61P29/00 , A61P37/06 , A61P3/00 , A61P9/00 , A61P11/06 , A61P37/08 , A61P19/08 , C07D519/00 , A61P25/28
CPC分类号： C07D513/04 , A61K31/55 , A61K31/551 , A61K45/06 , C07D495/04 , C07D519/00 , C07K14/81
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
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公开(公告)号：US07838517B2
公开(公告)日：2010-11-23
申请号：US12466420
申请日：2009-05-15
IPC分类号： C07D495/04 , C07D513/04 , C07D519/00 , A61K31/4188 , A61K31/4184 , A61K31/55
CPC分类号： C07D513/04 , A61K31/55 , A61K31/551 , A61K45/06 , C07D495/04 , C07D519/00 , C07K14/81
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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