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公开(公告)号：US07915305B2
公开(公告)日：2011-03-29
申请号：US11656876
申请日：2007-01-23
申请人： Guy Brenchley , Jean-Damien Charrier , Steven Durrant , David Kay , Ronald Knegtel , Sharn Ramaya , Shazia Sadiq
发明人： Guy Brenchley , Jean-Damien Charrier , Steven Durrant , David Kay , Ronald Knegtel , Sharn Ramaya , Shazia Sadiq
IPC分类号： A61K31/38
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinase represented by formula (I): or a pharmaceutically acceptable salt thereof. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作由式（I）表示的蛋白激酶抑制剂的化合物或其药学上可接受的盐。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US20090286840A1
公开(公告)日：2009-11-19
申请号：US11786579
申请日：2007-04-12
申请人： Guy Brenchley , Steven Durrant , Jean-Damien Charrier , Ronald Knegtel , Sharn Ramaya , Shazia Sadiq
发明人： Guy Brenchley , Steven Durrant , Jean-Damien Charrier , Ronald Knegtel , Sharn Ramaya , Shazia Sadiq
IPC分类号： A61K31/4178 , C07D409/04 , A61K31/4155 , A61P35/00 , A61P25/00 , A61P29/00 , A61P3/10
CPC分类号： C07D409/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US20120165378A1
公开(公告)日：2012-06-28
申请号：US13234332
申请日：2011-09-16
申请人： Guy Brenchley , Jean-Damien Charrier , Steven Durrant , Ronald Knegtel , Sharn Ramaya , Shazia Sadiq
发明人： Guy Brenchley , Jean-Damien Charrier , Steven Durrant , Ronald Knegtel , Sharn Ramaya , Shazia Sadiq
IPC分类号： A61K31/4196 , C07D409/14 , A61P35/00 , A61P25/28 , A61P37/00 , A61P29/00 , A61P37/06 , A61P37/02 , A61P25/00 , A61P9/00 , A61P19/08 , A61P1/16 , A61P31/12 , A61P7/00 , A61P3/10 , A61P35/02 , C12N9/99 , C07D409/04
CPC分类号： C07D409/04 , A61K31/4196 , A61K45/06 , C07D409/14 , C12N9/99
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, or disorders. The invention also relates to processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还涉及包含所述化合物的药学上可接受的组合物以及在治疗各种疾病，病症或病症中使用该化合物和组合物的方法。 本发明还涉及制备本发明化合物的方法。
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公开(公告)号：US08017781B2
公开(公告)日：2011-09-13
申请号：US11600311
申请日：2006-11-15
申请人： Guy Brenchley , Jean-Damien Charrier , Steven Durrant , Ronald Knegtel , Sharn Ramaya , Shazia Sadiq , Jingrong Cao
发明人： Guy Brenchley , Jean-Damien Charrier , Steven Durrant , Ronald Knegtel , Sharn Ramaya , Shazia Sadiq , Jingrong Cao
IPC分类号： A61K31/437 , C07D471/04
CPC分类号： C07D471/02 , C07D471/04 , C07D487/02
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US20110190507A1
公开(公告)日：2011-08-04
申请号：US12942287
申请日：2010-11-09
申请人： Guy Brenchley , Jean-Damien Charrier , Steven Durrant , Ronald Knegtel , Sharn Ramaya , Shazia Sadiq
发明人： Guy Brenchley , Jean-Damien Charrier , Steven Durrant , Ronald Knegtel , Sharn Ramaya , Shazia Sadiq
IPC分类号： C07D403/04 , C07D403/14
CPC分类号： C07D409/04 , A61K31/4196 , A61K45/06 , C07D409/14 , C12N9/99
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, or disorders. The invention also relates to processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还涉及包含所述化合物的药学上可接受的组合物以及在治疗各种疾病，病症或病症中使用该化合物和组合物的方法。 本发明还涉及制备本发明化合物的方法。
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公开(公告)号：US08039661B2
公开(公告)日：2011-10-18
申请号：US12942287
申请日：2010-11-09
申请人： Guy Brenchley , Jean-Damien Charrier , Steven Durrant , Ronald Knegtel , Sharn Ramaya , Shazia Sadiq
发明人： Guy Brenchley , Jean-Damien Charrier , Steven Durrant , Ronald Knegtel , Sharn Ramaya , Shazia Sadiq
IPC分类号： C07C209/22
CPC分类号： C07D409/04 , A61K31/4196 , A61K45/06 , C07D409/14 , C12N9/99
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, or disorders. The invention also relates to processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还涉及包含所述化合物的药学上可接受的组合物以及在治疗各种疾病，病症或病症中使用该化合物和组合物的方法。 本发明还涉及制备本发明化合物的方法。
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公开(公告)号：US07851495B2
公开(公告)日：2010-12-14
申请号：US11805243
申请日：2007-05-22
申请人： Guy Brenchley , Jean-Damien Charrier , Steven Durrant , Ronald Knegtel , Sharn Ramaya , Shazia Sadiq
发明人： Guy Brenchley , Jean-Damien Charrier , Steven Durrant , Ronald Knegtel , Sharn Ramaya , Shazia Sadiq
IPC分类号： A61K31/4196 , C07D249/08
CPC分类号： C07D409/04 , A61K31/4196 , A61K45/06 , C07D409/14 , C12N9/99
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, or disorders. The invention also relates to processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还涉及包含所述化合物的药学上可接受的组合物以及在治疗各种疾病，病症或病症中使用该化合物和组合物的方法。 本发明还涉及制备本发明化合物的方法。
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公开(公告)号：US07829590B2
公开(公告)日：2010-11-09
申请号：US11786579
申请日：2007-04-12
申请人： Guy Brenchley , Steven Durrant , Jean-Damien Charrier , Ronald Knegtel , Sharn Ramaya , Shazia Sadiq
发明人： Guy Brenchley , Steven Durrant , Jean-Damien Charrier , Ronald Knegtel , Sharn Ramaya , Shazia Sadiq
IPC分类号： A61K31/4155 , A61K31/4178 , C07D231/38 , C07D233/54
CPC分类号： C07D409/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinase, represented by structural formula I: or pharmaceutically acceptable salts thereof, wherein values of the variables of structural formula are as described in the specification and claims. The invention also provides pharmaceutically acceptable compositions comprising the compounds or salts, and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及用作结构式I表示的蛋白激酶抑制剂的化合物或其药学上可接受的盐，其中结构式变量的值如说明书和权利要求书所述。 本发明还提供包含该化合物或盐的药学上可接受的组合物，以及使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供制备本发明化合物的方法。
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公开(公告)号：US20080070965A1
公开(公告)日：2008-03-20
申请号：US11805243
申请日：2007-05-22
申请人： Guy Brenchley , Jean-Damien Charrier , Steven Durrant , Ronald Knegtel , Sharn Ramaya , Shazia Sadiq
发明人： Guy Brenchley , Jean-Damien Charrier , Steven Durrant , Ronald Knegtel , Sharn Ramaya , Shazia Sadiq
IPC分类号： A61K31/41 , C07D249/08
CPC分类号： C07D409/04 , A61K31/4196 , A61K45/06 , C07D409/14 , C12N9/99
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, or disorders. The invention also relates to processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还涉及包含所述化合物的药学上可接受的组合物以及在治疗各种疾病，病症或病症中使用该化合物和组合物的方法。 本发明还涉及制备本发明化合物的方法。
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公开(公告)号：US20080045570A1
公开(公告)日：2008-02-21
申请号：US11805418
申请日：2007-05-23
申请人： Guy Brenchley , Jean-Damien Charrier , Steven Durrant , Ronald Knegtel , Sharn Ramaya , Shazia Sadiq
发明人： Guy Brenchley , Jean-Damien Charrier , Steven Durrant , Ronald Knegtel , Sharn Ramaya , Shazia Sadiq
IPC分类号： A61K31/44 , A61P35/00 , C07D409/04 , C12N9/99
CPC分类号： C07D409/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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