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1.发明申请Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes 审中-公开人造染色体，其用途和制备人造染色体的方法公开(公告)号：US20090263898A1
公开(公告)日：2009-10-22
申请号：US12456142
申请日：2009-06-11
申请人： Gyula Hadlaczky , Aladar A. Szalay
发明人： Gyula Hadlaczky , Aladar A. Szalay
IPC分类号： C12N5/04
CPC分类号： C12N15/625 , A01K67/0275 , A01K2217/05 , A01K2217/072 , A01K2217/20 , A01K2227/105 , A01K2227/30 , A01K2267/01 , A01K2267/02 , A01K2267/025 , A01K2267/03 , A61K38/00 , A61K48/00 , C07K2319/036 , C07K2319/61 , C12N15/113 , C12N15/82 , C12N15/85 , C12N15/8509 , C12N2310/111 , C12N2800/20 , C12N2800/206 , C12N2800/208
摘要： Methods for preparing cell lines that contain artificial chromosomes, methods for preparation of artificial chromosomes, methods for purification of artificial chromosomes, methods for targeted insertion of heterologous DNA into artificial chromosomes, methods for amplification of nucleic acids and methods for delivery of the chromosomes to selected cells and tissues are provided. Also provided are cell lines for use in the methods, and cell lines and chromosomes produced by the methods. Methods for use of the artificial chromosomes are also provided.
摘要翻译： 用于制备含有人造染色体的细胞系的方法，人造染色体的制备方法，纯化人造染色体的方法，将异源DNA靶向插入人工染色体的方法，扩增核酸的方法和将染色体递送至所选择的方法 提供细胞和组织。 还提供了用于方法的细胞系，以及通过该方法产生的细胞系和染色体。 还提供了使用人造染色体的方法。
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2.发明授权Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes 失效人造染色体，其用途和制备人造染色体的方法公开(公告)号：US06743967B2
公开(公告)日：2004-06-01
申请号：US09096648
申请日：1998-06-12
申请人： Gyula Hadlaczky , Aladar A. Szalay
发明人： Gyula Hadlaczky , Aladar A. Szalay
IPC分类号： C12N1500
CPC分类号： C12N15/85 , A01K67/0275 , A01K2217/05 , A01K2227/10 , A01K2227/105 , A01K2227/30 , A01K2227/40 , A01K2267/01 , A01K2267/03 , A01K2267/0337 , A61K38/00 , A61K48/00 , C07K2319/036 , C07K2319/61 , C12N15/113 , C12N15/625 , C12N15/82 , C12N15/8509 , C12N2310/111 , C12N2800/20 , C12N2800/206 , C12N2800/208 , C12N2830/002
摘要： Methods for preparing cell lines that contain artificial chromosomes, methods for preparation of artificial chromosomes, methods for purification of artificial chromosomes, methods for targeted insertion of heterologous DNA into artificial chromosomes, and methods for delivery of the chromosomes to selected cells and tissues are provided. Also provided are cell lines for use in the methods, and cell lines and chromosomes produced by the methods. In particular, satellite artificial chromosomes that, except for inserted heterologous DNA, are substantially composed of heteroaromatic are provided. Methods for use of the artificial chromosomes, including for gene therapy, production of gene products and production of transgenic plants and animals are also provided.
摘要翻译： 提供了包含人造染色体的细胞系的制备方法，人造染色体的制备方法，纯化人造染色体的方法，将异源DNA靶向插入人造染色体的方法，以及将染色体递送至所选择的细胞和组织的方法。 还提供了用于方法的细胞系，以及通过该方法产生的细胞系和染色体。 特别地，提供除了插入的异源DNA之外，基本上由异染色质组成的卫星人造染色体。 还提供了使用人造染色体的方法，包括用于基因治疗，生产基因产物和转基因植物和动物的生产。
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3.发明授权Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes 失效人造染色体，其用途和制备人造染色体的方法
公开(公告)号：US6077697A
公开(公告)日：2000-06-20
申请号：US682080
申请日：1996-07-15
申请人： Gyula Hadlaczky , Aladar A. Szalay
发明人： Gyula Hadlaczky , Aladar A. Szalay
IPC分类号： A01H1/00 , A01H5/00 , A01K67/027 , A61K38/00 , A61K48/00 , C12N5/02 , C12N5/10 , C12N15/09 , C12N15/113 , C12N15/62 , C12N15/82 , C12N15/85 , C07H21/04 , C12N15/10
CPC分类号： C12N15/85 , A01K67/0275 , C12N15/113 , C12N15/625 , C12N15/82 , C12N15/8509 , A01K2217/05 , A01K2227/10 , A01K2227/105 , A01K2227/30 , A01K2227/40 , A01K2267/01 , A01K2267/03 , A01K2267/0337 , A61K38/00 , A61K48/00 , C07K2319/036 , C07K2319/61 , C12N2310/111 , C12N2800/20 , C12N2800/206 , C12N2800/208 , C12N2830/002
摘要： Methods for preparing cell lines that contain artificial chromosomes, methods for preparation of artificial chromosomes, methods for purification of artificial chromosomes, methods for targeted insertion of heterologous DNA into artificial chromosomes, and methods for delivery of the chromosomes to selected cells and tissues are provided. Also provided are cell lines for use in the methods, and cell lines and chromosomes produced by the methods. In particular, satellite artificial chromosomes that, except for inserted heterologous DNA, are substantially composed of heterochromatin are provided. Methods for use of the artificial chromosomes, including for gene therapy, production of gene products and production of transgenic plants and animals are also provided.
摘要翻译： 提供了包含人造染色体的细胞系的制备方法，人造染色体的制备方法，纯化人造染色体的方法，将异源DNA靶向插入人造染色体的方法，以及将染色体递送至所选择的细胞和组织的方法。 还提供了用于方法的细胞系，以及通过该方法产生的细胞系和染色体。 特别地，提供除了插入的异源DNA之外，基本上由异染色质组成的卫星人造染色体。 还提供了使用人造染色体的方法，包括用于基因治疗，生产基因产物和转基因植物和动物的生产。
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公开(公告)号：US6025155A
公开(公告)日：2000-02-15
申请号：US695191
申请日：1996-08-07
申请人： Gyula Hadlaczky , Aladar A. Szalay
发明人： Gyula Hadlaczky , Aladar A. Szalay
IPC分类号： A01H1/00 , A01H5/00 , A01K67/027 , A61K38/00 , A61K48/00 , C12N5/10 , C12N15/09 , C12N15/113 , C12N15/62 , C12N15/82 , C12N15/85 , C12N15/67 , C12P21/00
CPC分类号： C12N15/8509 , A01K67/0275 , C12N15/113 , C12N15/625 , C12N15/82 , C12N15/85 , A01K2217/05 , A01K2227/105 , A01K2227/30 , A01K2267/01 , A01K2267/03 , A61K38/00 , A61K48/00 , C07K2319/036 , C07K2319/61 , C12N2310/111 , C12N2800/20 , C12N2800/206 , C12N2800/208 , C12N2830/002
摘要： Methods for preparing cell lines that contain artificial chromosomes, methods for preparation of artificial chromosomes, methods for purification of artificial chromosomes, methods for targeted insertion of heterologous DNA into artificial chromosomes, and methods for delivery of the chromosomes to selected cells and tissues are provided. Also provided are cell lines for use in the methods, and cell lines and chromosomes produced by the methods. In particular, satellite artificial chromosomes that, except for inserted heterologous DNA, are substantially composed of heterochromatin are provided. Methods for use of the artificial chromosomes, including for gene therapy, production of gene products and production of transgenic plants and animals are also provided.
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5.发明授权Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes 失效人造染色体，其用途和制备人造染色体的方法公开(公告)号：US08389802B2
公开(公告)日：2013-03-05
申请号：US11284877
申请日：2005-11-21
申请人： Gyula Hadlaczky , Aladar A. Szalay
发明人： Gyula Hadlaczky , Aladar A. Szalay
CPC分类号： C12N15/625 , A01K67/0275 , A01K2217/05 , A01K2217/072 , A01K2217/20 , A01K2227/105 , A01K2227/30 , A01K2267/01 , A01K2267/02 , A01K2267/025 , A01K2267/03 , A61K38/00 , A61K48/00 , C07K2319/036 , C07K2319/61 , C12N15/113 , C12N15/82 , C12N15/85 , C12N15/8509 , C12N2310/111 , C12N2800/20 , C12N2800/206 , C12N2800/208
摘要： Methods for amplification of nucleic acids in cells are provided. Also provided are cells that contain the nucleic acids.
摘要翻译： 提供了细胞中核酸扩增的方法。 还提供了含有核酸的细胞。
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6.发明授权Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes 失效人造染色体，其用途和制备人造染色体的方法公开(公告)号：US08288610B2
公开(公告)日：2012-10-16
申请号：US11355288
申请日：2006-02-14
申请人： Gyula Hadlaczky , Aladar A. Szalay
发明人： Gyula Hadlaczky , Aladar A. Szalay
CPC分类号： C12N15/625 , A01K67/0275 , A01K2217/05 , A01K2217/072 , A01K2217/20 , A01K2227/105 , A01K2227/30 , A01K2267/01 , A01K2267/02 , A01K2267/025 , A01K2267/03 , A61K38/00 , A61K48/00 , C07K2319/036 , C07K2319/61 , C12N15/113 , C12N15/82 , C12N15/85 , C12N15/8509 , C12N2310/111 , C12N2800/20 , C12N2800/206 , C12N2800/208
摘要： Methods for amplification of nucleic acids in cells are provided. Also provided are cells that contain the nucleic acids.
摘要翻译： 提供了细胞中核酸扩增的方法。 还提供了含有核酸的细胞。
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公开(公告)号：US20060095984A1
公开(公告)日：2006-05-04
申请号：US11284877
申请日：2005-11-21
申请人： Gyula Hadlaczky , Aladar Szalay
发明人： Gyula Hadlaczky , Aladar Szalay
CPC分类号： C12N15/625 , A01K67/0275 , A01K2217/05 , A01K2217/072 , A01K2217/20 , A01K2227/105 , A01K2227/30 , A01K2267/01 , A01K2267/02 , A01K2267/025 , A01K2267/03 , A61K38/00 , A61K48/00 , C07K2319/036 , C07K2319/61 , C12N15/113 , C12N15/82 , C12N15/85 , C12N15/8509 , C12N2310/111 , C12N2800/20 , C12N2800/206 , C12N2800/208
摘要： Methods for amplification of nucleic acids in cells are provided. Also provided are cells that contain the nucleic acids.
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8.发明申请Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes 审中-公开人造染色体，其用途和制备人造染色体的方法公开(公告)号：US20070061920A1
公开(公告)日：2007-03-15
申请号：US11592435
申请日：2006-11-02
申请人： Gyula Hadlaczky , Aladar Szalay
发明人： Gyula Hadlaczky , Aladar Szalay
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2227/30 , A01K2267/01 , A01K2267/03 , A61K38/00 , A61K48/00 , C07K2319/036 , C07K2319/61 , C12N15/113 , C12N15/625 , C12N15/82 , C12N15/85 , C12N2310/111 , C12N2800/20 , C12N2800/206 , C12N2800/208 , C12N2830/002
摘要： Methods for preparing cell lines that contain artificial chromosomes, methods for preparation of artificial chromosomes, methods for purification of artificial chromosomes, methods for targeted insertion of heterologous DNA into artificial chromosomes, methods for amplification of nucleic acids and methods for delivery of the chromosomes to selected cells and tissues are provided. Also provided are cell lines for use in the methods, and cell lines and chromosomes produced by the methods. Methods for use of the artificial chromosomes are also provided.
摘要翻译： 用于制备含有人造染色体的细胞系的方法，人造染色体的制备方法，纯化人造染色体的方法，将异源DNA靶向插入人工染色体的方法，扩增核酸的方法和将染色体递送至所选择的方法 提供细胞和组织。 还提供了用于方法的细胞系，以及通过该方法产生的细胞系和染色体。 还提供了使用人造染色体的方法。
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9.发明申请Artificial chromosomes, uses thereof and method for preparing artificial chromosomes 失效人造染色体，其用途和人造染色体的制备方法公开(公告)号：US20060150271A1
公开(公告)日：2006-07-06
申请号：US11355288
申请日：2006-02-14
申请人： Gyula Hadlaczky , Aladar Szalay
发明人： Gyula Hadlaczky , Aladar Szalay
CPC分类号： C12N15/625 , A01K67/0275 , A01K2217/05 , A01K2217/072 , A01K2217/20 , A01K2227/105 , A01K2227/30 , A01K2267/01 , A01K2267/02 , A01K2267/025 , A01K2267/03 , A61K38/00 , A61K48/00 , C07K2319/036 , C07K2319/61 , C12N15/113 , C12N15/82 , C12N15/85 , C12N15/8509 , C12N2310/111 , C12N2800/20 , C12N2800/206 , C12N2800/208
摘要： Methods for amplification of nucleic acids in cells are provided. Also provided are cells that contain the nucleic acids.
摘要翻译： 提供了细胞中核酸扩增的方法。 还提供了含有核酸的细胞。
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10.发明申请Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes 审中-公开人造染色体，其用途和制备人造染色体的方法公开(公告)号：US20050153909A1
公开(公告)日：2005-07-14
申请号：US10151078
申请日：2002-05-16
申请人： Gyula Hadlaczky , Aladar Szalay
发明人： Gyula Hadlaczky , Aladar Szalay
IPC分类号： A01K67/027 , A61K38/00 , A61K48/00 , C12N15/113 , C12N15/62 , C12N15/82 , C12N15/85
CPC分类号： C12N15/625 , A01K67/0275 , A01K2217/05 , A01K2217/072 , A01K2217/20 , A01K2227/105 , A01K2227/30 , A01K2267/01 , A01K2267/02 , A01K2267/025 , A01K2267/03 , A61K38/00 , A61K48/00 , C07K2319/036 , C07K2319/61 , C12N15/113 , C12N15/82 , C12N15/85 , C12N15/8509 , C12N2310/111 , C12N2800/20 , C12N2800/206 , C12N2800/208
摘要： Methods for preparing cell lines that contain artificial chromosomes, methods for preparation of artificial chromosomes, methods for purification of artificial chromosomes, methods for targeted insertion of heterologous DNA into artificial chromosomes, and methods for delivery of the chromosomes to selected cells and tissues are provided. Also provided are cell lines for use in the methods, and cell lines and chromosomes produced by the methods. Methods for use of the artificial chromosomes are also provided.
摘要翻译： 提供了包含人造染色体的细胞系的制备方法，人造染色体的制备方法，纯化人造染色体的方法，将异源DNA靶向插入人造染色体的方法，以及将染色体递送至所选择的细胞和组织的方法。 还提供了用于方法的细胞系，以及通过该方法产生的细胞系和染色体。 还提供了使用人造染色体的方法。
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