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![1-[2-(2,4-Dimethylphenylsulfanyl)-Phenyl]Piperazine As A Compound With Combined Serotonin Reuptake, 5-HT3 And 5-HT1a Activity For The Treatment Of Cognitive Impairment](/abs-image/US/2014/09/11/US20140256943A1/abs.jpg.150x150.jpg)
1.发明申请1-[2-(2,4-Dimethylphenylsulfanyl)-Phenyl]Piperazine As A Compound With Combined Serotonin Reuptake, 5-HT3 And 5-HT1a Activity For The Treatment Of Cognitive Impairment 有权1- [2-（2,4-二甲基苯基硫基） - 苯基]哌嗪作为联合5-羟色胺再摄取的化合物，5-HT3和5-HT1a用于治疗认知功能障碍的活性公开(公告)号：US20140256943A1
公开(公告)日：2014-09-11
申请号：US14264373
申请日：2014-04-29
Applicant: H. Lundbeck A/S
Inventor： Andre Faldt , Lone Munch Ringgaard , Michael J. Mealy , Michael Harold Rock , Jorgen Brodersen , Morten Jorgensen
IPC: C07D295/096
CPC classification number: A61K31/495 , A61K9/14 , C07D295/096 , Y10T428/2982
Abstract: 1-[2-(2,4-dimethylphenylsulphanyl)phenyl]piperazine exhibits potent activity on SERT, 5-HT3 and 5-HT1A and may as such be useful for the treatment of cognitive impairment, especially in depressed patients.
Abstract translation: 1- [2-（2,4-二甲基苯基硫烷基）苯基]哌嗪显示出对SERT，5-HT3和5-HT1A的有效活性，并且可以用于治疗认知障碍，特别是抑郁症患者。
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![Process for preparing 1-[2-(2,4-dimethylphenysulfanyl)-pheny]piperazine or pharmaceutically acceptable salt thereof](/abs-image/US/2015/08/04/US09095588B2/abs.jpg.150x150.jpg)
2.发明授权Process for preparing 1-[2-(2,4-dimethylphenysulfanyl)-pheny]piperazine or pharmaceutically acceptable salt thereof 有权1- [2-（2,4-二甲基苯硫基） - 苯基]哌嗪或其药学上可接受的盐的制备方法公开(公告)号：US09095588B2
公开(公告)日：2015-08-04
申请号：US14472896
申请日：2014-08-29
Applicant: H. Lundbeck A/S
Inventor： Andre Faldt , Lone Munch Ringgaard , Michael J. Mealy , Michael Harold Rock , Jorgen Brodersen , Morten Jorgensen
IPC: C07D295/033 , A61K31/495 , C07D295/096
CPC classification number: A61K31/495 , A61K9/14 , C07D295/096 , Y10T428/2982
Abstract: This disclosure relates to a process for the preparation of 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl]piperazine or a salt thereof. The process includes reacting compound II with compound III and compound IV in the presence of a solvent, a base and a palladium catalyst. R, R′, X1, and X2 in the formulas above are defined in the Specification.
Abstract translation: 本公开涉及1- [2-（2,4-二甲基苯基硫基） - 苯基]哌嗪或其盐的制备方法。 该方法包括在溶剂，碱和钯催化剂存在下使化合物II与化合物III和化合物IV反应。 上述式中的R，R'，X 1和X 2在本说明书中定义。
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Patent Agency Ranking
![1-[2-(2,4-dimeihylphenylsulfanyl)-phenyl]piperazine as a compound with combined serotonin reuptake, 5-HT3 and 5-HT1A activity for the treatment of cognitive impairment](/abs-image/US/2022/10/04/US11458134B2/abs.jpg.150x150.jpg)
公开(公告)号：US11458134B2
公开(公告)日：2022-10-04
申请号：US16502677
申请日：2019-07-03
Applicant: H. Lundbeck A/S
Inventor： André Faldt , Heidi Lopez de Diego , Rene Holm , Michael J. Mealy
IPC: A61K31/495 , C07D295/096 , A61K9/14 , A61P25/22
Abstract: 1-[2-(2,4-dimethylphenylsulphanyl)phenyl]piperazine exhibits potent activity on SERT, 5-HT3 and 5-HT1A and may as such be useful for the treatment of cognitive impairment, especially in depressed patients.
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![1-[2-(2,4-DIMETHYLPHENYLSULFANYL)-PHENYL]PIPERAZINE AS A COMPOUND With COMBINED SEROTONIN REUPTAKE, 5-HT3 AND 5-HT1A ACTIVITY FOR THE TREATMENT OF COGNITIVE IMPAIRMENT](/abs-image/US/2016/03/24/US20160083359A1/abs.jpg.150x150.jpg)
4.发明申请1-[2-(2,4-DIMETHYLPHENYLSULFANYL)-PHENYL]PIPERAZINE AS A COMPOUND With COMBINED SEROTONIN REUPTAKE, 5-HT3 AND 5-HT1A ACTIVITY FOR THE TREATMENT OF COGNITIVE IMPAIRMENT 审中-公开1- [2-（2,4-二甲基苯基） - 苯基]哌嗪作为具有组合的丝氨酸反应的复合物，用于治疗认知损害的5-HT3和5-HT1A活性公开(公告)号：US20160083359A1
公开(公告)日：2016-03-24
申请号：US14948775
申请日：2015-11-23
Applicant: H. Lundbeck A/S
Inventor： Benny Bang-Andersen , André Faldt , Arne Mørk , Heidi Lopez De Diego , René Holm , Tine Bryan Stensbøl , Lone Munch Ringgard , Michael J. Mealy , Michael Harold Rock , Jørgen Brodersen , Morten Jørgensen , Nicholas Moore
IPC: C07D295/096
CPC classification number: A61K31/495 , A61K9/14 , A61P25/22 , C07D295/096 , Y10T428/2982
Abstract: 1-[2-(2,4-dimethylphenylsulphanyl)phenyl]piperazine exhibits potent activity on SERT, 5-HT3 and 5-HT1A and may as such be useful for the treatment of cognitive impairment, especially in depressed patients.
Abstract translation: 1- [2-（2,4-二甲基苯基硫烷基）苯基]哌嗪显示出对SERT，5-HT3和5-HT1A的有效活性，并且可以用于治疗认知障碍，特别是抑郁症患者。
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![Process for preparing 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl]piperazine or pharmaceutically acceptable salt thereof](/abs-image/US/2015/08/11/US09101626B2/abs.jpg.150x150.jpg)
5.发明授权Process for preparing 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl]piperazine or pharmaceutically acceptable salt thereof 有权1- [2-（2,4-二甲基苯基硫基） - 苯基]哌嗪或其药学上可接受的盐的制备方法公开(公告)号：US09101626B2
公开(公告)日：2015-08-11
申请号：US14264373
申请日：2014-04-29
Applicant: H. Lundbeck A/S
Inventor： Andre Faldt , Lone Munch Ringgaard , Michael J. Mealy , Michael Harold Rock , Jorgen Brodersen , Morten Jorgensen
IPC: C07D295/033 , A61K31/495 , C07D295/096
CPC classification number: A61K31/495 , A61K9/14 , C07D295/096 , Y10T428/2982
Abstract: This disclosure relates to a process for the preparation of 1-[2-(2,4-dimethylphenylsulfanyl) -phenyl]piperazine or a pharmaceutically acceptable salt thereof. The process includes reacting compound II with compound III and compound IV in the presence of a solvent, a base and a palladium catalyst. R, R′, Xi, and X2 in the formulas above are defined in the Specification.
Abstract translation: 本公开涉及1- [2-（2,4-二甲基苯基硫基） - 苯基]哌嗪或其药学上可接受的盐的制备方法。 该方法包括在溶剂，碱和钯催化剂存在下使化合物II与化合物III和化合物IV反应。 上述式中的R，R'，X 1和X 2在本说明书中定义。
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![1-[2-(2,4-Dimethylphenylsulfanyl)-Phenyl]Piperazine As A Compound With Combined Serotonin Reuptake, 5-HT3 And 5-HT1a Activity For The Treatment Of Cognitive Impairment](/abs-image/US/2014/12/18/US20140371453A1/abs.jpg.150x150.jpg)
6.发明申请1-[2-(2,4-Dimethylphenylsulfanyl)-Phenyl]Piperazine As A Compound With Combined Serotonin Reuptake, 5-HT3 And 5-HT1a Activity For The Treatment Of Cognitive Impairment 有权1- [2-（2,4-二甲基苯基硫基） - 苯基]哌嗪作为联合5-羟色胺再摄取的化合物，5-HT3和5-HT1a用于治疗认知功能障碍的活性公开(公告)号：US20140371453A1
公开(公告)日：2014-12-18
申请号：US14472896
申请日：2014-08-29
Applicant: H. Lundbeck A/S
Inventor： Andre Faldt , Lone Munch Ringgaard , Michael J. Mealy , Michael Harold Rock , Jorgen Brodersen , Morten Jorgensen
IPC: C07D295/096
CPC classification number: A61K31/495 , A61K9/14 , C07D295/096 , Y10T428/2982
Abstract: This disclosure relates to a process for the preparation of 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl]piperazine or a salt thereof.
Abstract translation: 本公开涉及1- [2-（2,4-二甲基苯基硫基） - 苯基]哌嗪或其盐的制备方法。
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![1-[2-(2,4-DIMETHYLPHENYLSULFANYL)-PHENYL]PIPERAZINE AS A COMPOUND WITH COMBINED SEROTONIN REUPTAKE, 5-HT3 AND 5-HT1A ACTIVITY FOR THE TREATMENT OF COGNITIVE IMPAIRMENT](/abs-image/US/2023/01/26/US20230021520A1/abs.jpg.150x150.jpg)
公开(公告)号：US20230021520A1
公开(公告)日：2023-01-26
申请号：US17949188
申请日：2022-09-20
Applicant: H. Lundbeck A/S
Inventor： André Faldt , Heidi Lopez de Diego , Rene Holm , Michael J. Mealy
IPC: A61K31/495 , C07D295/096 , A61K9/14
Abstract: 1-[2-(2,4-dimethylphenylsulphanyl)phenyl]piperazine exhibits potent activity on SERT, 5-HT3 and 5-HT1A and may as such be useful for the treatment of cognitive impairment, especially in depressed patients.
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