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公开(公告)号：US10195186B2
公开(公告)日：2019-02-05
申请号：US15584425
申请日：2017-05-02
申请人： H. Lundbeck A/S
IPC分类号： A61K31/44 , C07D213/75 , C07D215/38 , C07D333/66 , C07D401/04 , C07D403/04 , C07D237/20 , C07D239/42 , C07D241/20 , C07D277/46 , C07D213/40 , C07D409/04 , A61K31/4402 , A61K31/4406 , C07D417/04 , C07D213/60 , C07D213/65 , C07D333/68 , A61K31/381 , A61K31/426 , A61K31/47 , A61K31/4965 , A61K31/50 , A61K31/505
摘要： The present invention is directed to N-substituted-5-substituted phthalamic acids which of formula (A). The compounds are considered useful for the treatment of diseases treatment of a neurodegenerative disease, psychiatric disease, motoneuron disease, peripheral neuropathies, pain, neuroinflammation or atherosclerosis such as Alzheimer's disease and Parkinson's disease.
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2.发明申请公开(公告)号：US20150368231A1
公开(公告)日：2015-12-24
申请号：US14763544
申请日：2014-01-27
申请人： H. Lundbeck A/S
IPC分类号： C07D409/04 , C07D333/68 , C07D239/42 , C07D241/20 , C07D403/04 , C07D215/38 , C07D237/20 , C07D213/40 , C07D401/04 , C07D213/75 , C07D277/46
CPC分类号： A61K31/44 , A61K31/381 , A61K31/426 , A61K31/4402 , A61K31/4406 , A61K31/47 , A61K31/4965 , A61K31/50 , A61K31/505 , C07D213/40 , C07D213/60 , C07D213/65 , C07D213/75 , C07D215/38 , C07D237/20 , C07D239/42 , C07D241/20 , C07D277/46 , C07D333/66 , C07D333/68 , C07D401/04 , C07D403/04 , C07D409/04 , C07D417/04
摘要： The present invention is directed to N-substituted-5-substituted phthalamic acids which of formula (A). The compounds are considered useful for the treatment of diseases treatment of a neurodegenerative disease, psychiatric disease, motorneuron disease, peripheral neuropathies, pain, neuroinflammation or atherosclerosis such as Alzheimer's disease and Parkinson's disease.
摘要翻译： 本发明涉及式（A）的N-取代-5-取代的邻氨基苯甲酸。 认为这些化合物可用于治疗神经变性疾病，精神病，运动神经元疾病，周围神经病，疼痛，神经炎症或动脉粥样硬化如阿尔茨海默氏病和帕金森病的疾病治疗。
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公开(公告)号：US20150336942A1
公开(公告)日：2015-11-26
申请号：US14758884
申请日：2013-12-30
发明人： Gitte Kobberøe Mikkelsen , Laurent David , Stephen Watson , Garrick Paul Smith , Douglas Stewart Williamson , I-Jen Chen
IPC分类号： C07D413/14 , C07D403/14
CPC分类号： A61K31/5377 , A61K31/4439 , A61K31/4545 , A61K31/497 , C07D401/04 , C07D401/14 , C07D403/14 , C07D413/04 , C07D413/14
摘要： The present invention is directed to aminopyridine derived compounds of formula (A). The compounds are considered useful for the treatment of diseases associated with LRRK2 such a Lewy body dementia, Parkinson's disease or cancer.
摘要翻译： 本发明涉及氨基吡啶衍生的式（A）化合物。 该化合物被认为可用于治疗与LRRK2相关的疾病如路易体痴呆，帕金森病或癌症。
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公开(公告)号：US09682967B2
公开(公告)日：2017-06-20
申请号：US14763544
申请日：2014-01-27
申请人： H. Lundbeck A/S
IPC分类号： C07D409/04 , C07D213/75 , C07D215/38 , C07D333/66 , C07D401/04 , C07D403/04 , C07D237/20 , C07D239/42 , C07D241/20 , C07D277/46 , C07D213/40 , A61K31/44 , A61K31/4402 , A61K31/4406 , C07D417/04 , C07D213/60 , C07D213/65 , C07D333/68
CPC分类号： A61K31/44 , A61K31/381 , A61K31/426 , A61K31/4402 , A61K31/4406 , A61K31/47 , A61K31/4965 , A61K31/50 , A61K31/505 , C07D213/40 , C07D213/60 , C07D213/65 , C07D213/75 , C07D215/38 , C07D237/20 , C07D239/42 , C07D241/20 , C07D277/46 , C07D333/66 , C07D333/68 , C07D401/04 , C07D403/04 , C07D409/04 , C07D417/04
摘要： The present invention is directed to N-substituted-5-substituted phthalamic acids which of formula (A). The compounds are considered useful for the treatment of diseases treatment of a neurodegenerative disease, psychiatric disease, motorneuron disease, peripheral neuropathies, pain, neuroinflammation or atherosclerosis such as Alzheimer's disease and Parkinson's disease.
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公开(公告)号：US09393248B1
公开(公告)日：2016-07-19
申请号：US15071955
申请日：2016-03-16
发明人： Gitte Kobberøe Mikkelsen , Laurent David , Stephen Watson , Garrick Paul Smith , Douglas Stewart Williamson , I-Jen Chen
IPC分类号： A61K31/5377 , A61K31/4439 , A61K31/4545 , A61K31/497
CPC分类号： A61K31/5377 , A61K31/4439 , A61K31/4545 , A61K31/497 , C07D401/04 , C07D401/14 , C07D403/14 , C07D413/04 , C07D413/14
摘要： The present invention is directed to aminopyridine derived compounds of formula (A) The compounds are considered useful for the treatment of diseases associated with LRRK2 such as a Lewy body dementia, Parkinson's disease or cancer.
摘要翻译： 本发明涉及衍生自式（A）的氨基吡啶衍生化合物。该化合物被认为可用于治疗与LRRK2相关的疾病，例如路易体痴呆，帕金森病或癌症。
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公开(公告)号：US20170239226A1
公开(公告)日：2017-08-24
申请号：US15584425
申请日：2017-05-02
申请人： H. Lundbeck A/S
IPC分类号： A61K31/44 , A61K31/505 , A61K31/4965 , A61K31/50 , A61K31/4406 , A61K31/426 , A61K31/47 , A61K31/381 , A61K31/4402
CPC分类号： A61K31/44 , A61K31/381 , A61K31/426 , A61K31/4402 , A61K31/4406 , A61K31/47 , A61K31/4965 , A61K31/50 , A61K31/505 , C07D213/40 , C07D213/60 , C07D213/65 , C07D213/75 , C07D215/38 , C07D237/20 , C07D239/42 , C07D241/20 , C07D277/46 , C07D333/66 , C07D333/68 , C07D401/04 , C07D403/04 , C07D409/04 , C07D417/04
摘要： The present invention is directed to N-substituted-5-substituted phthalamic acids which of formula (A). The compounds are considered useful for the treatment of diseases treatment of a neurodegenerative disease, psychiatric disease, motoneuron disease, peripheral neuropathies, pain, neuroinflammation or atherosclerosis such as Alzheimer's disease and Parkinson's disease.
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公开(公告)号：US20160184317A1
公开(公告)日：2016-06-30
申请号：US15071955
申请日：2016-03-16
发明人： Gitte Kobberøe Mikkelsen , Laurent David , Stephen Watson , Garrick Paul Smith , Douglas Stewart Williamson , I-Jen Chen
IPC分类号： A61K31/5377 , A61K31/4545 , A61K31/497 , A61K31/4439
CPC分类号： A61K31/5377 , A61K31/4439 , A61K31/4545 , A61K31/497 , C07D401/04 , C07D401/14 , C07D403/14 , C07D413/04 , C07D413/14
摘要： The present invention is directed to aminopyridine derived compounds of formula (A) The compounds are considered useful for the treatment of diseases associated with LRRK2 such a Lewy body dementia, Parkinson's disease or cancer.
摘要翻译： 本发明涉及衍生自式（A）的氨基吡啶衍生化合物。该化合物被认为可用于治疗与LRRK2相关的疾病如路易体痴呆，帕金森病或癌症。
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公开(公告)号：US09321748B2
公开(公告)日：2016-04-26
申请号：US14758884
申请日：2013-12-30
发明人： Gitte Kobberøe Mikkelsen , Laurent David , Stephen Watson , Garrick Paul Smith , Douglas Stewart Williamson , I-Jen Chen
IPC分类号： C07D401/04 , C07D401/14 , C07D403/14 , C07D413/04 , C07D413/14
CPC分类号： A61K31/5377 , A61K31/4439 , A61K31/4545 , A61K31/497 , C07D401/04 , C07D401/14 , C07D403/14 , C07D413/04 , C07D413/14
摘要： The present invention is directed to aminopyridine derived compounds of formula (A). The compounds are considered useful for the treatment of diseases associated with LRRK2 such a Lewy body dementia, Parkinson's disease or cancer.
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