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公开(公告)号：US20080187523A1
公开(公告)日：2008-08-07
申请号：US11999549
申请日：2007-12-06
申请人： H. Steve Zhang , Philip D. Gregory
发明人： H. Steve Zhang , Philip D. Gregory
CPC分类号： C07K14/4705 , A61K38/00 , C07K14/4702 , C07K14/811 , C07K2319/71 , C07K2319/81 , C12N2799/022 , C12N2799/025 , C12N2799/028
摘要： Disclosed herein are methods and compositions for treatment of conditions requiring inhibition of angiogenesis. Such conditions include those characterized by neovascularization, such as retinopathies, macular degeneration and various malignancies.
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公开(公告)号：US07358085B2
公开(公告)日：2008-04-15
申请号：US11365390
申请日：2006-02-28
申请人： H. Steve Zhang , Philip D. Gregory
发明人： H. Steve Zhang , Philip D. Gregory
CPC分类号： C07K14/4705 , A61K38/00 , C07K14/4702 , C07K14/811 , C07K2319/71 , C07K2319/81 , C12N2799/022 , C12N2799/025 , C12N2799/028
摘要： Disclosed herein are methods and compositions for treatment of conditions requiring inhibition of angiogenesis. Such conditions include those characterized by neovascularization, such as retinopathies, macular degeneration and various malignancies.
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公开(公告)号：US08012946B1
公开(公告)日：2011-09-06
申请号：US12008245
申请日：2008-01-09
CPC分类号： C07K14/4705 , A61K38/00 , C07K14/4702 , C07K14/811 , C07K2319/71 , C07K2319/81 , C12N2799/022 , C12N2799/025 , C12N2799/028
摘要： Disclosed herein are methods and compositions for treatment of conditions requiring inhibition of angiogenesis. Such conditions include those characterized by neovascularization, such as retinopathies, macular degeneration and various malignancies.
摘要翻译： 本文公开了用于治疗需要抑制血管发生的病症的方法和组合物。 这些病症包括以新生血管形成为特征，如视网膜病变，黄斑变性和各种恶性肿瘤。
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公开(公告)号：US07795209B2
公开(公告)日：2010-09-14
申请号：US11981385
申请日：2007-10-31
申请人： H. Steve Zhang , Philip D. Gregory
发明人： H. Steve Zhang , Philip D. Gregory
CPC分类号： C07K14/4705 , A61K38/00 , C07K14/4702 , C07K14/811 , C07K2319/71 , C07K2319/81 , C12N2799/022 , C12N2799/025 , C12N2799/028
摘要： Disclosed herein are methods and compositions for treatment of conditions requiring inhibition of angiogenesis. Such conditions include those characterized by neovascularization, such as retinopathies, macular degeneration and various malignancies.
摘要翻译： 本文公开了用于治疗需要抑制血管发生的病症的方法和组合物。 这些病症包括以新生血管形成为特征，如视网膜病变，黄斑变性和各种恶性肿瘤。
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5.发明授权公开(公告)号：US09234016B2
公开(公告)日：2016-01-12
申请号：US12804764
申请日：2010-07-28
CPC分类号： A61K38/1709 , A61K38/00 , A61K48/00 , C07K14/47 , C07K2319/00 , C07K2319/71 , C07K2319/81 , C12N15/907
摘要： Disclosed herein are methods and compositions for treating trinucleotide repeat disorders.
摘要翻译： 本文公开了用于治疗三核苷酸重复障碍的方法和组合物。
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公开(公告)号：US07893022B2
公开(公告)日：2011-02-22
申请号：US11981386
申请日：2007-10-31
CPC分类号： C07K14/4705 , A61K38/00 , C07K14/4702 , C07K14/811 , C07K2319/71 , C07K2319/81 , C12N2799/022 , C12N2799/025 , C12N2799/028
摘要： Disclosed herein are methods and compositions for treatment of conditions requiring inhibition of angiogenesis. Such conditions include those characterized by neovascularization, such as retinopathies, macular degeneration and various malignancies.
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公开(公告)号：US07732196B2
公开(公告)日：2010-06-08
申请号：US11999549
申请日：2007-12-06
CPC分类号： C07K14/4705 , A61K38/00 , C07K14/4702 , C07K14/811 , C07K2319/71 , C07K2319/81 , C12N2799/022 , C12N2799/025 , C12N2799/028
摘要： Disclosed herein are methods and compositions for treatment of conditions requiring inhibition of angiogenesis. Such conditions include those characterized by neovascularization, such as retinopathies, macular degeneration and various malignancies.
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8.发明申请ZINC FINGER NUCLEASE MODIFICATION OF LEUCINE RICH REPEAT KINASE 2 (LRRK2) MUTANT FIBROBLASTS AND IPSCS 审中-公开激光重复激酶2（LRRK2）突变体和IPSCS的ZINC指纹核修饰公开(公告)号：US20120214241A1
公开(公告)日：2012-08-23
申请号：US13327322
申请日：2011-12-15
CPC分类号： C12N9/22 , C07K2319/00 , C07K2319/80 , C07K2319/81 , C12N9/12
摘要： Disclosed herein are methods and compositions for alteration of an LRRK2 gene in a fibroblast or iPSC.
摘要翻译： 本文公开了用于在成纤维细胞或iPSC中改变LRRK2基因的方法和组合物。
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公开(公告)号：US07534775B2
公开(公告)日：2009-05-19
申请号：US11101095
申请日：2005-04-07
申请人： H. Steve Zhang , Lei Zhang
发明人： H. Steve Zhang , Lei Zhang
CPC分类号： C07K14/4703 , A61K48/00
摘要： Methods and compositions are provided for modulating cardiac contractility by regulating transcription of the phsopholamban gene using engineered zinc finger proteins.
摘要翻译： 提供的方法和组合物通过使用工程化锌指蛋白调节phhopholamban基因的转录来调节心脏收缩力。
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