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1.发明授权公开(公告)号：US08124057B2
公开(公告)日：2012-02-28
申请号：US12320431
申请日：2009-01-26
CPC分类号： A61K9/0078 , A61K9/0075 , A61K9/008 , A61K9/146 , A61K9/1694 , A61K9/19 , Y10S514/826 , Y10S514/851 , Y10S514/872
摘要： There invention discloses aqueous dispersions of nanoparticulate aerosol formulations, dry powder nanoparticulate aerosol formulation, propellant-based aerosol formulations, methods of using the formulations in aerosol delivery devices, and methods of making such formulations. The nanoparticles of the aqueous dispersions or dry powder formulations comprise insoluble drug particles having a surface modifier on the surface thereof.
摘要翻译： 本发明公开了纳米颗粒气雾剂配方的水性分散体，干燥粉末纳米颗粒气溶胶配制剂，基于推进剂的气溶胶制剂，在气溶胶递送装置中使用制剂的方法，以及制备这些制剂的方法。 含水分散体或干粉配方的纳米颗粒包含在其表面上具有表面改性剂的不溶性药物颗粒。
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公开(公告)号：US06811767B1
公开(公告)日：2004-11-02
申请号：US09597738
申请日：2000-06-19
IPC分类号： A61K912
CPC分类号： A61K9/0078 , A61K9/0075 , A61K9/008 , A61K9/146 , A61K9/1694 , A61K9/19 , Y10S514/826 , Y10S514/851 , Y10S514/872
摘要： There invention discloses aqueous dispersions of nanoparticulate aerosol formulations, dry powder nanoparticulate aerosol formulation, propellant-based aerosol formulations, methods of using the formulations in aerosol delivery devices, and methods of making such formulations. The nanoparticles of the aqueous dispersions or dry powder formulations comprise insoluble drug particles having a surface modifier on the surface thereof.
摘要翻译： 本发明公开了纳米颗粒气雾剂配方的水性分散体，干燥粉末纳米颗粒气溶胶配制剂，基于推进剂的气溶胶制剂，在气溶胶递送装置中使用制剂的方法，以及制备这些制剂的方法。 含水分散体或干粉配方的纳米颗粒包含在其表面上具有表面改性剂的不溶性药物颗粒。
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公开(公告)号：US07521068B2
公开(公告)日：2009-04-21
申请号：US09190138
申请日：1998-11-12
IPC分类号： A61K8/00 , A61K9/14 , A61K9/16 , A61K31/12 , A61K31/04 , A61K31/28 , A61K31/33 , A61K31/56 , A61K31/70 , A61K38/00 , A61K38/02
CPC分类号： A61K9/0078 , A61K9/0075 , A61K9/008 , A61K9/146 , A61K9/1694 , A61K9/19 , Y10S514/826 , Y10S514/851 , Y10S514/872
摘要： There invention discloses aqueous dispersions of nanoparticulate aerosol formulations, dry powder nanoparticulate aerosol formulation, propellant-based aerosol formulations, methods of using the formulations in aerosol delivery devices, and methods of making such formulations. The nanoparticles of the aqueous dispersions or dry powder formulations comprise insoluble drug particles having a surface modifier on the surface thereof.
摘要翻译： 本发明公开了纳米颗粒气雾剂配方的水性分散体，干燥粉末纳米颗粒气溶胶配制剂，基于推进剂的气溶胶制剂，在气溶胶递送装置中使用制剂的方法，以及制备这些制剂的方法。 含水分散体或干粉配方的纳米颗粒包含在其表面上具有表面改性剂的不溶性药物颗粒。
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公开(公告)号：US20120213829A1
公开(公告)日：2012-08-23
申请号：US13404790
申请日：2012-02-24
IPC分类号： A61K9/14 , A61P29/00 , A61P11/06 , A61P11/00 , A61P37/06 , A61P31/10 , A61P31/06 , A61P35/00 , A61P9/00 , A61P31/00 , A61K31/192 , A61K31/58 , A61P37/00 , A61P11/08 , A61P1/08 , A61K31/573 , A61K38/02 , B82B1/00 , B82Y5/00
CPC分类号： A61K9/0078 , A61K9/0075 , A61K9/008 , A61K9/146 , A61K9/1694 , A61K9/19 , Y10S514/826 , Y10S514/851 , Y10S514/872
摘要： There invention discloses aqueous dispersions of nanoparticulate aerosol formulations, dry powder nanoparticulate aerosol formulation, propellant-based aerosol formulations, methods of using the formulations in aerosol delivery devices, and methods of making such formulations. The nanoparticles of the aqueous dispersions or dry powder formulations comprise insoluble drug particles having a surface modifier on the surface thereof.
摘要翻译： 本发明公开了纳米颗粒气雾剂配方的水性分散体，干燥粉末纳米颗粒气溶胶配制剂，基于推进剂的气溶胶制剂，在气溶胶递送装置中使用制剂的方法，以及制备这些制剂的方法。 含水分散体或干粉配方的纳米颗粒包含在其表面上具有表面改性剂的不溶性药物颗粒。
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公开(公告)号：US20090181100A1
公开(公告)日：2009-07-16
申请号：US12320431
申请日：2009-01-26
CPC分类号： A61K9/0078 , A61K9/0075 , A61K9/008 , A61K9/146 , A61K9/1694 , A61K9/19 , Y10S514/826 , Y10S514/851 , Y10S514/872
摘要： There invention discloses aqueous dispersions of nanoparticulate aerosol formulations, dry powder nanoparticulate aerosol formulation, propellant-based aerosol formulations, methods of using the formulations in aerosol delivery devices, and methods of making such formulations. The nanoparticles of the aqueous dispersions or dry powder formulations comprise insoluble drug particles having a surface modifier on the surface thereof.
摘要翻译： 本发明公开了纳米颗粒气雾剂配方的水性分散体，干燥粉末纳米颗粒气溶胶配制剂，基于推进剂的气溶胶制剂，在气溶胶递送装置中使用制剂的方法，以及制备这些制剂的方法。 含水分散体或干粉配方的纳米颗粒包含在其表面上具有表面改性剂的不溶性药物颗粒。
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6.发明授权Bioadhesive nanoparticulate compositions having cationic surface stabilizers 有权具有阳离子表面稳定剂的生物粘附纳米颗粒组合物公开(公告)号：US07288267B2
公开(公告)日：2007-10-30
申请号：US10004808
申请日：2001-12-07
CPC分类号： A01N25/12 , A01N25/24 , A01N25/30 , A61K8/0241 , A61K8/36 , A61K8/416 , A61K8/49 , A61K8/553 , A61K8/63 , A61K8/73 , A61K8/731 , A61K8/8147 , A61K8/8182 , A61K9/113 , A61K9/145 , A61K9/146 , A61K2800/413 , A61K2800/612 , A61K2800/614 , A61Q5/00 , A61Q19/00 , B82Y5/00
摘要： Bioadhesive nanoparticulate compositions, comprising active agent particles and one or more cationic surface stabilizers, are described. The cationic surface stabilizers prevent aggregation of the nanoparticles and increase bioadhesion of the nanoparticles to biological substrates, such as an insect, teeth, bone, nails, chitin, feathers, scales, mucous, skin, hair, plant tissue, etc. The particles may consist of pharmacologically active compounds (e.g., drug compounds for human or veterinary use), agricultural chemicals (pesticides, herbicides, fertilizers, and the like), cosmetic agents, consumer products (coloring agents, flavors, or fragrances), or other materials which function by interacting with biological substrates. In addition, the invention relates to methods of preparing and using such bioadhesive nanoparticulate compositions.
摘要翻译： 描述了包含活性剂颗粒和一种或多种阳离子表面稳定剂的生物粘附纳米颗粒组合物。 阳离子表面稳定剂防止纳米颗粒聚集并增加纳米颗粒对生物底物（如昆虫，牙齿，骨骼，指甲，甲壳质，羽毛，鳞屑，粘液，皮肤，毛发，植物组织等）的生物粘附。 化学药剂，消费品（着色剂，调味剂或香料）或其他材料的药物活性化合物（例如，用于人或兽用药物的化合物），农药（农药，除草剂，肥料等） 通过与生物底物相互作用起作用。 此外，本发明涉及制备和使用这些生物粘附纳米颗粒组合物的方法。
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7.发明授权Bioadhesive nanoparticulate compositions having cationic surface stabilizers 失效具有阳离子表面稳定剂的生物粘附纳米颗粒组合物公开(公告)号：US06428814B1
公开(公告)日：2002-08-06
申请号：US09414159
申请日：1999-10-08
IPC分类号： A61K950
CPC分类号： A01N25/12 , A01N25/24 , A01N25/30 , A61K8/0241 , A61K8/36 , A61K8/416 , A61K8/49 , A61K8/553 , A61K8/63 , A61K8/73 , A61K8/731 , A61K8/8147 , A61K8/8182 , A61K9/113 , A61K9/145 , A61K9/146 , A61K2800/413 , A61K2800/612 , A61K2800/614 , A61Q5/00 , A61Q19/00 , B82Y5/00
摘要： Bioadhesive nanoparticulate compositions, comprising active agent particles and one or more cationic surface stabilizers, are described. The cationic surface stabilizers prevent aggregation of the nanoparticles and increase bioadhesion of the nanoparticles to biological substrates, such as an insect, teeth, bone, nails, chitin, feathers, scales, mucous, skin, hair, plant tissue, etc. The particles may consist of pharmacologically active compounds (e.g., drug compounds for human or veterinary use), agricultural chemicals (pesticides, herbicides, fertilizers, and the like), cosmetic agents, consumer products (coloring agents, flavors, or fragrances), or other materials which function by interacting with biological substrates. In addition, the invention relates to methods of preparing and using such bioadhesive nanoparticulate compositions.
摘要翻译： 描述了包含活性剂颗粒和一种或多种阳离子表面稳定剂的生物粘附纳米颗粒组合物。 阳离子表面稳定剂防止纳米颗粒聚集并增加纳米颗粒对生物底物（如昆虫，牙齿，骨骼，指甲，甲壳质，羽毛，鳞屑，粘液，皮肤，毛发，植物组织等）的生物粘附。 化学药剂，消费品（着色剂，调味剂或香料）或其他材料的药物活性化合物（例如，用于人或兽用药物的化合物），农药（农药，除草剂，肥料等） 通过与生物底物相互作用起作用。 此外，本发明涉及制备和使用这些生物粘附纳米颗粒组合物的方法。
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8.发明授权Bioadhesive nanoparticulate compositions having cationic surface stabilizers 有权具有阳离子表面稳定剂的生物粘附纳米颗粒组合物公开(公告)号：US07850995B2
公开(公告)日：2010-12-14
申请号：US11898274
申请日：2007-09-11
IPC分类号： A61K9/14
CPC分类号： A01N25/12 , A01N25/24 , A01N25/30 , A61K8/0241 , A61K8/36 , A61K8/416 , A61K8/49 , A61K8/553 , A61K8/63 , A61K8/73 , A61K8/731 , A61K8/8147 , A61K8/8182 , A61K9/113 , A61K9/145 , A61K9/146 , A61K2800/413 , A61K2800/612 , A61K2800/614 , A61Q5/00 , A61Q19/00 , B82Y5/00
摘要： Bioadhesive nanoparticulate compositions, comprising active agent particles and one or more cationic surface stabilizers, are described. The cationic surface stabilizers prevent aggregation of the nanoparticles and increase bioadhesion of the nanoparticles to biological substrates, such as an insect, teeth, bone, nails, chitin, feathers, scales, mucous, skin, hair, plant tissue, etc. The particles may consist of pharmacologically active compounds (e.g., drug compounds for human or veterinary use), agricultural chemicals (pesticides, herbicides, fertilizers, and the like), cosmetic agents, consumer products (coloring agents, flavors, or fragrances), or other materials which function by interacting with biological substrates. In addition, the invention relates to methods of preparing and using such bioadhesive nanoparticulate compositions.
摘要翻译： 描述了包含活性剂颗粒和一种或多种阳离子表面稳定剂的生物粘附纳米颗粒组合物。 阳离子表面稳定剂防止纳米颗粒聚集并增加纳米颗粒对生物底物（如昆虫，牙齿，骨骼，指甲，甲壳质，羽毛，鳞屑，粘液，皮肤，毛发，植物组织等）的生物粘附。 化学药剂，消费品（着色剂，调味剂或香料）或其他材料的药物活性化合物（例如，用于人或兽用药物的化合物），农药（农药，除草剂，肥料等） 通过与生物底物相互作用起作用。 此外，本发明涉及制备和使用这些生物粘附纳米颗粒组合物的方法。
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9.发明授权公开(公告)号：US09283177B2
公开(公告)日：2016-03-15
申请号：US12218624
申请日：2008-07-16
申请人： David M. Cohen , Eugene R. Cooper
发明人： David M. Cohen , Eugene R. Cooper
IPC分类号： A61K31/164 , A61K9/00 , A61K9/06 , A61K31/167 , A61K47/02 , A61K47/10 , A61K47/38
CPC分类号： A61K9/0019 , A61K9/06 , A61K31/164 , A61K31/167 , A61K47/02 , A61K47/10 , A61K47/38
摘要： The invention relates to a drug delivery system for the topical administration of anesthetic agents. For example, a topical anesthetic for rapid local anesthesia is provided. The topical anesthetic includes an anesthetic, volatile and non-volatile solvents, and an optional thickener. In addition, a method is taught for applying the topical anesthetic to the face of a patient without occlusion. The anesthetic is applied topically to an area for injection such that the dermatological procedure (cosmetic injections) can be performed in fifteen minutes.
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10.发明申请BI-FUNCTIONAL CO-POLYMER USE FOR OPTHALMIC AND OTHER TOPICAL AND LOCAL APPLICATIONS 有权双功能聚合物用于非对称和其他局部和本地应用公开(公告)号：US20100226963A1
公开(公告)日：2010-09-09
申请号：US12708329
申请日：2010-02-18
CPC分类号： A61K31/785 , A61K9/0019 , A61K9/0043 , A61K9/0048 , A61K9/0051 , A61K9/0073 , A61K9/5031 , A61K9/5146 , A61K31/045 , A61K31/7036 , A61K31/74 , A61K31/765 , A61K35/02 , A61K45/06 , A61K47/34 , G02C7/04
摘要： The invention contemplates a copolymer which is a graft or block copolymer useful to change wettability and surface characteristics of biological surfaces. Methods for use of these formulations and coatings to change wettability and sterically stabilize, and lubricate biological surfaces in a subject, for example, in the treatment of dry eye syndrome, and to prevent adherence of unwanted proteins, for example in the treatment of contact lens intolerance, are provided.
摘要翻译： 本发明涉及一种共聚物，其是可用于改变生物表面的润湿性和表面特性的接枝或嵌段共聚物。 使用这些制剂和涂层以改变受试者的润湿性和空间稳定性以及润滑生物表面的方法，例如治疗干眼综合征，以及防止不需要的蛋白质的粘附，例如用于治疗隐形眼镜 不容忍，被提供。
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