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公开(公告)号：US11806718B2
公开(公告)日：2023-11-07
申请号：US17496182
申请日：2021-10-07
申请人： HANDYLAB, INC.
CPC分类号： B01L7/52 , B01L3/502715 , B01L3/502723 , B01L9/527 , C12Q1/686 , G01N21/6428 , B01L3/502738 , B01L2200/025 , B01L2200/027 , B01L2200/0684 , B01L2300/021 , B01L2300/022 , B01L2300/045 , B01L2300/046 , B01L2300/0861 , B01L2300/1805 , B01L2300/1822 , B01L2300/1827 , B01L2300/1838 , B01L2300/1861 , G01N2021/6419 , Y10S435/808
摘要： The present technology provides for a fluorescent detector that is configured to detect light emitted for a probe characteristic of a polynucleotide. The polynucleotide is undergoing amplification in a microfluidic channel with which the detector is in optical communication. The detector is configured to detect minute quantities of polynucleotide, such as would be contained in a microfluidic volume. The detector can also be multiplexed to permit multiple concurrent measurements on multiple polynucleotides concurrently.
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公开(公告)号：US20230041595A1
公开(公告)日：2023-02-09
申请号：US17930823
申请日：2022-09-09
申请人： HANDYLAB, INC.
发明人： Betty Wu , John S. Althaus , Nikhil Phadke , Sundaresh N. Brahmasandra , Kalyan Handique , Aaron Kehrer , Gene Parunak , Cecelia Haley , Ted Springer
IPC分类号： C12Q1/6806 , B01L3/00 , F16K99/00 , C12N15/10 , C12Q1/686 , B01F25/433 , B01F33/30
摘要： Methods and systems for processing polynucleotides (e.g., DNA) are disclosed. A processing region includes one or more surfaces (e.g., particle surfaces) modified with ligands that retain polynucleotides under a first set of conditions (e.g., temperature and pH) and release the polynucleotides under a second set of conditions (e.g., higher temperature and/or more basic pH). The processing region can be used to, for example, concentrate polynucleotides of a sample and/or separate inhibitors of amplification reactions from the polynucleotides. Microfluidic devices with a processing region are disclosed.
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公开(公告)号：US11266987B2
公开(公告)日：2022-03-08
申请号：US16119812
申请日：2018-08-31
申请人： HandyLab, Inc.
发明人： Kalyan Handique
摘要： The technology described herein generally relates to microfluidic cartridges configured to amplify and detect polynucleotides extracted from multiple biological samples in parallel. The technology includes a microfluidic substrate, comprising: a plurality of sample lanes, wherein each of the plurality of sample lanes comprises a microfluidic network having, in fluid communication with one another: an inlet; a first valve and a second valve; a first channel leading from the inlet, via the first valve, to a reaction chamber; and a second channel leading from the reaction chamber, via the second valve, to a vent.
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公开(公告)号：US20210362155A1
公开(公告)日：2021-11-25
申请号：US17131558
申请日：2020-12-22
申请人： HANDYLAB, INC.
发明人： Jeff Williams , Kerry Wilson , Kalyan Handique
摘要： The technology described herein generally relates to systems for extracting polynucleotides from multiple samples, particularly from biological samples, and additionally to systems that subsequently amplify and detect the extracted polynucleotides. The technology more particularly relates to microfluidic systems that carry out PCR on multiple samples of nucleotides of interest within microfluidic channels, and detect those nucleotides.
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公开(公告)号：US11142785B2
公开(公告)日：2021-10-12
申请号：US16787977
申请日：2020-02-11
申请人： Handylab, Inc.
摘要： The present technology provides for an apparatus for detecting polynucleotides in samples, particularly from biological samples. The technology more particularly relates to microfluidic systems that carry out PCR on nucleotides of interest within microfluidic channels, and detect those nucleotides. The apparatus includes a microfluidic cartridge that is configured to accept a plurality of samples, and which can carry out PCR on each sample individually, or a group of, or all of the plurality of samples simultaneously.
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公开(公告)号：US11141734B2
公开(公告)日：2021-10-12
申请号：US17085320
申请日：2020-10-30
申请人： HANDYLAB, INC.
摘要： The present technology provides for a fluorescent detector that is configured to detect light emitted for a probe characteristic of a polynucleotide. The polynucleotide is undergoing amplification in a microfluidic channel with which the detector is in optical communication. The detector is configured to detect minute quantities of polynucleotide, such as would be contained in a microfluidic volume. The detector can also be multiplexed to permit multiple concurrent measurements on multiple polynucleotides concurrently.
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公开(公告)号：US20210276008A1
公开(公告)日：2021-09-09
申请号：US17068140
申请日：2020-10-12
申请人： HANDYLAB, INC.
发明人： Kalyan Handique , Sundaresh N. Brahmasandra , Karthik Ganesan , Betty Wu , Nikhil Phadke , Gene Parunak , Jeff Williams
摘要： This patent application describes an integrated apparatus for processing polynucleotide-containing samples, and for providing a diagnostic result thereon. The apparatus is configured to receive a microfluidic cartridge that contains reagents and a network for processing a sample. Also described are methods of using the apparatus.
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公开(公告)号：US11085069B2
公开(公告)日：2021-08-10
申请号：US17146403
申请日：2021-01-11
申请人： HandyLab, Inc.
摘要： The present technology provides for an apparatus for detecting polynucleotides in samples, particularly from biological samples. The technology more particularly relates to microfluidic systems that carry out PCR on nucleotides of interest within microfluidic channels, and detect those nucleotides. The apparatus includes a microfluidic cartridge that is configured to accept a plurality of samples, and which can carry out PCR on each sample individually, or a group of, or all of the plurality of samples simultaneously.
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公开(公告)号：US20210121887A1
公开(公告)日：2021-04-29
申请号：US16924867
申请日：2020-07-09
申请人： HandyLab, Inc.
发明人： Kalyan Handique
摘要： The present technology provides for a heater substrate that contains networks of heater elements configured to controllably and selectively deliver heat to one or more PCR reaction chambers in a microfluidic substrate with which the heater substrate makes contact. In exemplary embodiments, the heater substrate can deliver heat to 12, 24, 48, or 96 chambers independently of one another, or simultaneously. The heater substrate is located in a heater unit that may be introduced into a diagnostic apparatus that can receive and position a microfluidic substrate, such as in a cartridge, in contact with the heater unit, receive one or more polynucleotide containing samples into one or more lanes in the microfluidic substrate, and cause amplification of the polynucleotides to occur, and detect presence of absence of specified polynucleotides in the amplified samples.
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公开(公告)号：US10913061B2
公开(公告)日：2021-02-09
申请号：US16730763
申请日：2019-12-30
申请人： HANDYLAB, INC.
发明人： Kalyan Handique , Sundaresh N. Brahmasandra , Karthik Ganesan , Betty Wu , Nikhil Phadke , Gene Parunak , Jeff Williams
摘要： This patent application describes an integrated apparatus for processing polynucleotide-containing samples, and for providing a diagnostic result thereon. The apparatus is configured to receive a microfluidic cartridge that contains reagents and a network for processing a sample. Also described are methods of using the apparatus.
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