公开(公告)号：US09688618B2

公开(公告)日：2017-06-27

申请号：US15280817

申请日：2016-09-29

Applicant: HAWAII BIOTECH, INC.

Inventor： Alan Thomas Johnson ,  Seong Jin Kim ,  Sean O'Malley ,  Henry Lee Jackson

IPC: C07C259/06 ,  C07D213/56 ,  C07D295/16 ,  C07D207/337 ,  C07C259/10 ,  C07D239/26 ,  C07D239/42 ,  C07D231/12 ,  C07D295/205 ,  C07D295/155 ,  C07D303/46

CPC classification number: C07C259/06 ,  C07C259/10 ,  C07C2601/02 ,  C07D207/337 ,  C07D211/34 ,  C07D213/56 ,  C07D231/12 ,  C07D233/64 ,  C07D239/26 ,  C07D239/42 ,  C07D295/155 ,  C07D295/16 ,  C07D295/185 ,  C07D295/205 ,  C07D303/46

Abstract: Compounds of formula I are provided: R1 is an alkoxy or O(CH2)pX, p is an integer from 2 to 3 and X is OH, NH2, or CO2H, m is an integer from 0 to 5, n is an integer from 0 to 5, each R2 is independently selected from hydrogen, alkenyl, hydroxyalkyl, alkoxymethyl, heterocyclyl, hetereocyclylmethyl, amino, amido, hydroxamido, any of which may be optionally substituted with one or more of acyl, alkyl, alkoxy, hydroxyalkyl, or halogen, each R3 is independently selected from hydrogen, halogen, alkyl, alkenyl, carboxy, hydroxymethyl, amido, and at least one of R2 and R3 is not hydrogen.

公开(公告)号：US09505710B2

公开(公告)日：2016-11-29

申请号：US15099438

申请日：2016-04-14

Applicant: HAWAII BIOTECH, INC.

Inventor： Alan Thomas Johnson ,  Seong Jin Kim ,  Sean O'Malley ,  Henry Lee Jackson

IPC: C07C259/06 ,  C07D213/56 ,  C07D295/16 ,  C07C259/10 ,  C07D207/337 ,  C07D239/26 ,  C07D239/42 ,  C07D231/12 ,  C07D295/185 ,  C07D295/155 ,  C07D233/64 ,  C07D303/46 ,  C07D211/34

CPC classification number: C07C259/06 ,  C07C259/10 ,  C07C2601/02 ,  C07D207/337 ,  C07D211/34 ,  C07D213/56 ,  C07D231/12 ,  C07D233/64 ,  C07D239/26 ,  C07D239/42 ,  C07D295/155 ,  C07D295/16 ,  C07D295/185 ,  C07D295/205 ,  C07D303/46

Abstract: Compounds of formula I are provided: R1 is an alkoxy or O(CH2)pX, p is an integer from 2 to 3 and X is OH, NH2, or CO2H, m is an integer from 0 to 5, n is an integer from 0 to 5, each R2 is independently selected from hydrogen, alkenyl, hydroxyalkyl, alkoxymethyl, heterocyclyl, hetereocyclylmethyl, amino, amido, hydroxamido, any of which may be optionally substituted with one or more of acyl, alkyl, alkoxy, hydroxyalkyl, or halogen, each R3 is independently selected from hydrogen, halogen, alkyl, alkenyl, carboxy, hydroxymethyl, amido, and at least one of R2 and R3 is not hydrogen.

Abstract translation: R1为烷氧基或O（CH2）pX，p为2〜3的整数，X为OH，NH2或CO2H，m为0〜5的整数，n为0〜5的整数，R2为 其中任何一个可以任选被一个或多个酰基，烷基，烷氧基，羟基烷基或卤素取代，每个R 3独立地选自氢，烯基，羟基烷基，烷氧基甲基，杂环基，杂环基甲基，氨基，酰氨基， 氢，卤素，烷基，烯基，羧基，羟甲基，酰氨基，并且R 2和R 3中的至少一个不是氢。

公开(公告)号：US20170036996A1

公开(公告)日：2017-02-09

申请号：US15280817

申请日：2016-09-29

Applicant: HAWAII BIOTECH, INC.

Inventor： Alan Thomas Johnson ,  Seong Jin Kim ,  Sean O'Malley ,  Henry Lee Jackson

IPC: C07C259/06 ,  C07D295/16 ,  C07D207/337 ,  C07C259/10 ,  C07D303/46 ,  C07D239/42 ,  C07D231/12 ,  C07D295/205 ,  C07D295/155 ,  C07D213/56 ,  C07D239/26

CPC classification number: C07C259/06 ,  C07C259/10 ,  C07C2601/02 ,  C07D207/337 ,  C07D211/34 ,  C07D213/56 ,  C07D231/12 ,  C07D233/64 ,  C07D239/26 ,  C07D239/42 ,  C07D295/155 ,  C07D295/16 ,  C07D295/185 ,  C07D295/205 ,  C07D303/46

Abstract: Compounds of formula I are provided: R1 is an alkoxy or O(CH2)pX, p is an integer from 2 to 3 and X is OH, NH2, or CO2H, m is an integer from 0 to 5, n is an integer from 0 to 5, each R2 is independently selected from hydrogen, alkenyl, hydroxyalkyl, alkoxymethyl, heterocyclyl, hetereocyclylmethyl, amino, amido, hydroxamido, any of which may be optionally substituted with one or more of acyl, alkyl, alkoxy, hydroxyalkyl, or halogen, each R3 is independently selected from hydrogen, halogen, alkyl, alkenyl, carboxy, hydroxymethyl, amido, and at least one of R2 and R3 is not hydrogen.

Abstract translation: R1为烷氧基或O（CH2）pX，p为2〜3的整数，X为OH，NH2或CO2H，m为0〜5的整数，n为0〜5的整数，R2为 其中任何一个可以任选被一个或多个酰基，烷基，烷氧基，羟基烷基或卤素取代，每个R 3独立地选自氢，烯基，羟基烷基，烷氧基甲基，杂环基，杂环基甲基，氨基，酰氨基， 氢，卤素，烷基，烯基，羧基，羟甲基，酰氨基，并且R 2和R 3中的至少一个不是氢。

公开(公告)号：US20160304443A1

公开(公告)日：2016-10-20

申请号：US15099438

申请日：2016-04-14

Applicant: HAWAII BIOTECH, INC.

Inventor： Alan Thomas Johnson ,  Seong Jin Kim ,  Sean O'Malley ,  Henry Lee Jackson

IPC: C07C259/06 ,  C07D295/16 ,  C07C259/10 ,  C07D207/337 ,  C07D239/26 ,  C07D211/34 ,  C07D231/12 ,  C07D295/185 ,  C07D295/155 ,  C07D233/64 ,  C07D303/46 ,  C07D213/56 ,  C07D239/42

CPC classification number: C07C259/06 ,  C07C259/10 ,  C07C2601/02 ,  C07D207/337 ,  C07D211/34 ,  C07D213/56 ,  C07D231/12 ,  C07D233/64 ,  C07D239/26 ,  C07D239/42 ,  C07D295/155 ,  C07D295/16 ,  C07D295/185 ,  C07D295/205 ,  C07D303/46

Abstract: Compounds of formula I are provided: R1 is an alkoxy or O(CH2)pX, p is an integer from 2 to 3 and X is OH, NH2, or CO2H, m is an integer from 0 to 5, n is an integer from 0 to 5, each R2 is independently selected from hydrogen, alkenyl, hydroxyalkyl, alkoxymethyl, heterocyclyl, hetereocyclylmethyl, amino, amido, hydroxamido, any of which may be optionally substituted with one or more of acyl, alkyl, alkoxy, hydroxyalkyl, or halogen, each R3 is independently selected from hydrogen, halogen, alkyl, alkenyl, carboxy, hydroxymethyl, amido, and at least one of R2 and R3 is not hydrogen.

Abstract translation: R1为烷氧基或O（CH2）pX，p为2〜3的整数，X为OH，NH2或CO2H，m为0〜5的整数，n为0〜5的整数，R2为 其中任何一个可以任选被一个或多个酰基，烷基，烷氧基，羟基烷基或卤素取代，每个R 3独立地选自氢，烯基，羟基烷基，烷氧基甲基，杂环基，杂环基甲基，氨基，酰氨基， 氢，卤素，烷基，烯基，羧基，羟甲基，酰氨基，并且R 2和R 3中的至少一个不是氢。