公开(公告)号：US11794186B2

公开(公告)日：2023-10-24

申请号：US17384376

申请日：2021-07-23

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： Pavel Kornilovich ,  Alexander Govyadinov ,  Anand Samuel Jebakumar

IPC: B01L3/00

CPC classification number: B01L3/502738 ,  B01L2200/0605 ,  B01L2300/18 ,  B01L2400/0622

Abstract: An example microfluidic device comprises a plurality of fluidic channels and a fluidic multiplexor. The fluidic multiplexor includes a plurality of fluidic micro-valves fluidically coupled to the plurality of fluidic channels, and a plurality of control lines that cross the plurality of fluidic channels proximal to the plurality of fluidic micro-valves.

公开(公告)号：US20240299942A1

公开(公告)日：2024-09-12

申请号：US18573690

申请日：2021-06-30

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Carson Denison ,  Pavel Kornilovich ,  Alexander Govyadinov ,  Erik D. Torniainen ,  Richard W. Seaver ,  Anand Samuel Jebakumar

IPC: B01L3/00

CPC classification number: B01L3/502746 ,  B01L2300/0816 ,  B01L2300/087 ,  B01L2300/0874 ,  B01L2400/086

Abstract: A microfluidic device includes a chamber having a floor, a ceiling, and an inlet. The microfluidic device includes pillars extending from the floor to the ceiling of the chamber. Each pillar has a leading surface or corner, a trailing surface or corner opposite the leading surface or corner, and trailing side surfaces adjoining the trailing surface or corner. Each pillar is oriented along a corresponding ray intersecting the leading surface or corner and the trailing surface or corner. Adjacent pillars have a turn angle between the corresponding rays of the adjacent pillars, and each pillar has a pillar angle between the trailing side surfaces thereof. The turn and pillar angles are based on a fluidic contact angle to promote fluid flow from the inlet throughout the chamber during priming without fluidic pinning.

公开(公告)号：US20240246084A1

公开(公告)日：2024-07-25

申请号：US18559761

申请日：2021-05-10

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Carson Denison ,  Alexander Govyadinov ,  Richard W. Seaver ,  Erik D. Torniainen ,  Pavel Kornilovich ,  Anand Samuel Jebakumar

IPC: B01L7/00

CPC classification number: B01L7/52 ,  B01L2300/1805 ,  B01L2300/1894

Abstract: Apparatuses may be used for nucleic acid amplification. An example apparatus may include an amplification chamber to contain a biochemical reaction associated with amplification of a biologic sample. The biologic sample may include a nucleic acid. The apparatus may also include a heater thermally coupled to the amplification chamber. The apparatus may also include a thermally conductive substrate in contact with the heater and including a liquid coolant passage to pass a liquid coolant through the thermally conductive substrate.