公开(公告)号：US20230303996A1

公开(公告)日：2023-09-28

申请号：US18023316

申请日：2020-08-28

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Jacob Shane Sasser ,  Alexander Govyadinov ,  Brian J. Keefe ,  David S. Clague ,  Natalie Taylor Weisenburger ,  Nicolas Robert Medjo

IPC: C12N15/10 ,  B01L3/00

CPC classification number: C12N15/1006 ,  B01L3/502761 ,  B01L2400/086 ,  B01L2200/0652

Abstract: In one example in accordance with the present disclosure, a fluid manipulation system is described. The fluid manipulation system includes a microfluidic channel through which fluid is to flow. The fluid includes biomolecules to be separated. The fluid manipulation system also includes at least one array of biomolecule-capturing pillars disposed within the microfluidic channel to capture biomolecules from the fluid. Barriers rise from a surface of the microfluidic channel. The barriers span a width of the microfluidic channel orthogonal to a flow of the fluid to induce vortices in the fluid flow.

公开(公告)号：US20220062901A1

公开(公告)日：2022-03-03

申请号：US17459997

申请日：2021-08-27

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： Brian J. Keefe ,  Alexander Govyadinov ,  Jae Elliot De Leon ,  Braden Thomas Andrews ,  David S. Clague

IPC: B01L3/00

Abstract: In one example in accordance with the present disclosure, a fluid manipulation system is described. The fluid manipulation system includes a microfluidic channel through which fluid is to flow. The fluid includes particles to be separated. The fluid manipulation system includes a first electrode pair on a first side of the microfluidic channel. The first electrode pair includes a top electrode formed on a lid of the microfluidic channel and a bottom electrode formed on a floor of the microfluidic channel. The fluid manipulation system also includes a second electrode pair on a second side of the microfluidic channel. The second electrode pair also includes a top electrode and a bottom electrode. The electrode pairs are to generate an alternating electrical field across the microfluidic channel.