公开(公告)号：US08168669B2

公开(公告)日：2012-05-01

申请号：US12491698

申请日：2009-06-25

申请人： Hideki Matsumoto ,  Tomohisa Okutsu ,  Tomoko Takeda ,  Hideki Suzuki ,  Tetsuo Yano ,  Masaki Hashimoto ,  Miho Ono ,  Manabu Suzuki

发明人： Hideki Matsumoto ,  Tomohisa Okutsu ,  Tomoko Takeda ,  Hideki Suzuki ,  Tetsuo Yano ,  Masaki Hashimoto ,  Miho Ono ,  Manabu Suzuki

IPC分类号： A61K31/197 ,  A61K31/4172 ,  A61K31/4184

CPC分类号： A61K31/198 ,  A61K31/405 ,  A61K31/4172 ,  Y02A50/411 ,  A61K2300/00

摘要： Disclosed is an agent for use in the treatment or prevention of inflammatory bowel disease. Also disclosed is an agent for inhibiting the production of TNF-α. A therapeutic or prophylactic agent for inflammatory bowel disease comprising at least one amino acid selected from the group consisting of lysine, histidine, phenylalanine, methionine, tryptophan, glutamine, glycine, cysteine, cystine and threonine, the amino acid being administered at a dose of 0.1 to 4000 mg/kg per day; and a TNF-α production inhibitor comprising an amino acid selected from the group consisting of histidine, phenylalanine and tryptophan, the amino acid being administered at a dose of 0.1 to 4000 mg/kg per day.

摘要翻译： 公开了用于治疗或预防炎症性肠病的药剂。 还公开了抑制TNF-α产生的药剂。 包含至少一种选自赖氨酸，组氨酸，苯丙氨酸，甲硫氨酸，色氨酸，谷氨酰胺，甘氨酸，半胱氨酸，胱氨酸和苏氨酸的氨基酸的炎症性肠病治疗或预防剂，所述氨基酸以 每日0.1〜4000mg / kg; 和包含选自组氨酸，苯丙氨酸和色氨酸的氨基酸的TNF-α产生抑制剂，所述氨基酸以每天0.1至4000mg / kg的剂量施用。

公开(公告)号：US20080108684A1

公开(公告)日：2008-05-08

申请号：US11968343

申请日：2008-01-02

申请人： HIDEKI MATSUMOTO ,  Tomohisa Okutsu ,  Tomoko Takeda ,  Hideki Suzuki ,  Tetsuo Yano ,  Masaki Hashimoto ,  Miho Ono ,  Manabu Suzuki

发明人： HIDEKI MATSUMOTO ,  Tomohisa Okutsu ,  Tomoko Takeda ,  Hideki Suzuki ,  Tetsuo Yano ,  Masaki Hashimoto ,  Miho Ono ,  Manabu Suzuki

IPC分类号： A61K31/4172 ,  A61K31/405 ,  A61K31/198

CPC分类号： A61K31/198 ,  A61K31/405 ,  A61K31/4172 ,  Y02A50/411 ,  A61K2300/00

摘要： Disclosed is an agent for use in the treatment or prevention of inflammatory bowel disease. Also disclosed is an agent for inhibiting the production of TNF-α. A therapeutic or prophylactic agent for inflammatory bowel disease comprising at least one amino acid selected from the group consisting of lysine, histidine, phenylalanine, methionine, tryptophan, glutamine, glycine, cysteine, cystine and threonine, the amino acid being administered at a dose of 0.1 to 4000 mg/kg per day; and a TNF-α production inhibitor comprising an amino acid selected from the group consisting of histidine, phenylalanine and tryptophan, the amino acid being administered at a dose of 0.1 to 4000 mg/kg per day.

摘要翻译： 公开了用于治疗或预防炎症性肠病的药剂。 还公开了抑制TNF-α产生的药剂。 包含至少一种选自赖氨酸，组氨酸，苯丙氨酸，甲硫氨酸，色氨酸，谷氨酰胺，甘氨酸，半胱氨酸，胱氨酸和苏氨酸的氨基酸的炎症性肠病治疗或预防剂，所述氨基酸以 每日0.1〜4000mg / kg; 和包含选自组氨酸，苯丙氨酸和色氨酸的氨基酸的TNF-α产生抑制剂，所述氨基酸以每天0.1至4000mg / kg的剂量施用。

公开(公告)号：US20120329846A1

公开(公告)日：2012-12-27

申请号：US13431183

申请日：2012-03-27

申请人： Hideki Matsumoto ,  Tomohisa Okutsu ,  Tomoko Takeda ,  Hideki Suzuki ,  Tetsuo Yano ,  Masaki Hashimoto ,  Miho Ono ,  Manabu Suzuki

发明人： Hideki Matsumoto ,  Tomohisa Okutsu ,  Tomoko Takeda ,  Hideki Suzuki ,  Tetsuo Yano ,  Masaki Hashimoto ,  Miho Ono ,  Manabu Suzuki

IPC分类号： A61K31/198 ,  C07D233/64 ,  C07C323/58 ,  C07D209/16 ,  C07C229/24 ,  A61P29/00 ,  C07C229/36 ,  A61K31/4172 ,  A61K31/195 ,  A61K31/405 ,  A61P1/00 ,  C07C229/26 ,  C07C229/08

CPC分类号： A61K31/198 ,  A61K31/405 ,  A61K31/4172 ,  Y02A50/411 ,  A61K2300/00

摘要： Disclosed is an agent for use in the treatment or prevention of inflammatory bowel disease. Also disclosed is an agent for inhibiting the production of TNF-α. A therapeutic or prophylactic agent for inflammatory bowel disease comprising at least one amino acid selected from the group consisting of lysine, histidine, phenylalanine, methionine, tryptophan, glutamine, glycine, cysteine, cystine and threonine, the amino acid being administered at a dose of 0.1 to 4000 mg/kg per day; and a TNF-α production inhibitor comprising an amino acid selected from the group consisting of histidine, phenylalanine and tryptophan, the amino acid being administered at a dose of 0.1 to 4000 mg/kg per day.

摘要翻译： 公开了用于治疗或预防炎症性肠病的药剂。 还公开了抑制TNF-α产生的药剂。 包含至少一种选自赖氨酸，组氨酸，苯丙氨酸，甲硫氨酸，色氨酸，谷氨酰胺，甘氨酸，半胱氨酸，胱氨酸和苏氨酸的氨基酸的炎症性肠病治疗或预防剂，所述氨基酸以 每日0.1〜4000mg / kg; 和包含选自组氨酸，苯丙氨酸和色氨酸的氨基酸的TNF-α产生抑制剂，所述氨基酸以每天0.1至4000mg / kg的剂量施用。

公开(公告)号：US20100076044A1

公开(公告)日：2010-03-25

申请号：US12491698

申请日：2009-06-25

申请人： Hideki MATSUMOTO ,  Tomohisa Okutsu ,  Tomoko Takeda ,  Hideki Suzuki ,  Tetsuo Yano ,  Masaki Hashimoto ,  Miho Ono ,  Manabu Suzuki

发明人： Hideki MATSUMOTO ,  Tomohisa Okutsu ,  Tomoko Takeda ,  Hideki Suzuki ,  Tetsuo Yano ,  Masaki Hashimoto ,  Miho Ono ,  Manabu Suzuki

IPC分类号： A61K31/197 ,  A61K31/405 ,  A61K31/4164 ,  A61P1/00

CPC分类号： A61K31/198 ,  A61K31/405 ,  A61K31/4172 ,  Y02A50/411 ,  A61K2300/00

摘要： Disclosed is an agent for use in the treatment or prevention of inflammatory bowel disease. Also disclosed is an agent for inhibiting the production of TNF-α. A therapeutic or prophylactic agent for inflammatory bowel disease comprising at least one amino acid selected from the group consisting of lysine, histidine, phenylalanine, methionine, tryptophan, glutamine, glycine, cysteine, cystine and threonine, the amino acid being administered at a dose of 0.1 to 4000 mg/kg per day; and a TNF-α production inhibitor comprising an amino acid selected from the group consisting of histidine, phenylalanine and tryptophan, the amino acid being administered at a dose of 0.1 to 4000 mg/kg per day.

摘要翻译： 公开了用于治疗或预防炎症性肠病的药剂。 还公开了抑制TNF-α产生的药剂。 包含至少一种选自赖氨酸，组氨酸，苯丙氨酸，甲硫氨酸，色氨酸，谷氨酰胺，甘氨酸，半胱氨酸，胱氨酸和苏氨酸的氨基酸的炎症性肠病治疗或预防剂，所述氨基酸以 每日0.1〜4000mg / kg; 和包含选自组氨酸，苯丙氨酸和色氨酸的氨基酸的TNF-α产生抑制剂，所述氨基酸以每天0.1至4000mg / kg的剂量施用。

公开(公告)号：US07902179B2

公开(公告)日：2011-03-08

申请号：US10475097

申请日：2002-04-26

申请人： Yasuhiro Tanaka ,  Kohichi Fujita ,  Yoshitomo Chujoh ,  Syunsuke Fukuda ,  Yuka Ikenoue ,  Tomoyuki Tagami ,  Akira Chiba ,  Ariko Kodaira ,  Hideki Matsumoto ,  Tadakiyo Nakagawa ,  Tatsuhiro Yamada ,  Manabu Suzuki ,  Masahiro Murata

发明人： Yasuhiro Tanaka ,  Kohichi Fujita ,  Yoshitomo Chujoh ,  Syunsuke Fukuda ,  Yuka Ikenoue ,  Tomoyuki Tagami ,  Akira Chiba ,  Ariko Kodaira ,  Hideki Matsumoto ,  Tadakiyo Nakagawa ,  Tatsuhiro Yamada ,  Manabu Suzuki ,  Masahiro Murata

IPC分类号： A61K31/44

CPC分类号： C07D471/04 ,  A61K31/437 ,  Y02A50/411

摘要： A pharmaceutical composition containing a heterocyclic compound of the formula (I) wherein each symbol is as defined in the specification, an isomer thereof, a solvate thereof or a pharmaceutically acceptable salt thereof as an active ingredient has a superior TNF-α production suppressing action. Accordingly, it is useful for the prophylaxis or treatment of various diseases caused by abnormal production of TNF-α.

摘要翻译： 含有式（I）的杂环化合物的药物组合物，其中每个符号如说明书中所定义，其异构体，其溶剂化物或其药学上可接受的盐作为活性成分具有优异的TNF-α产生抑制作用。 因此，可以预防或治疗由TNF-α异常产生引起的各种疾病。

公开(公告)号：US08409775B2

公开(公告)日：2013-04-02

申请号：US12676531

申请日：2008-09-05

申请人： Manabu Suzuki ,  Yutaka Murai

发明人： Manabu Suzuki ,  Yutaka Murai

IPC分类号： G03G9/08

CPC分类号： C08J3/246 ,  C08J3/05 ,  C08J2367/06 ,  G03G9/0804 ,  G03G9/0806 ,  G03G9/08793 ,  G03G9/08795 ,  G03G9/08797 ,  G03G9/09314 ,  G03G9/0935 ,  G03G9/09357 ,  G03G9/09371 ,  G03G9/09392

摘要： The present invention relates to a toner for electrophotography which has a small particle size and is excellent in all of low-temperature fusing ability, anti-hot offset property and image characteristics and a process for producing the toner, as well as to a dispersion of crosslinked resin particles which is used for production of the toner for electrophotography and a process for producing the dispersion of crosslinked resin particles. The dispersion of crosslinked resin particles having a volume median particle size (D50) of from 0.05 to 0.7 μm according to the present invention is produced by a process including the steps of (A) neutralizing a resin containing an acid group-containing polyester in an aqueous medium to obtain a dispersion of resin particles; and (B) mixing the dispersion of resin particles obtained in the step (A) with an oxazoline group-containing polymer at a temperature of from 60 to 100° C.

摘要翻译： 本发明涉及一种电子照相用调色剂，其具有小的粒径，并且全部具有优异的低温熔合性，抗热粘合性和图像特性以及调色剂的制备方法以及分散体 用于电子照相用调色剂的交联树脂颗粒和交联树脂颗粒分散体的制备方法。 根据本发明的体积中值粒径（D50）为0.05〜0.7μm的交联树脂颗粒的分散体是通过包括以下步骤的方法生产的：（A）将包含含酸基的聚酯的树脂中和 水性介质，得到树脂颗粒的分散体; 和（B）将步骤（A）中获得的树脂颗粒的分散体与含恶唑啉基的聚合物在60至100℃的温度下混合。

公开(公告)号：US08257574B2

公开(公告)日：2012-09-04

申请号：US12398818

申请日：2009-03-05

申请人： Hitoshi Muramatsu ,  Seiya Kunioka ,  Nobuyuki Suzuki ,  Akira Ishibashi ,  Minoru Imai ,  Manabu Suzuki ,  Masahiro Ogawa

发明人： Hitoshi Muramatsu ,  Seiya Kunioka ,  Nobuyuki Suzuki ,  Akira Ishibashi ,  Minoru Imai ,  Manabu Suzuki ,  Masahiro Ogawa

IPC分类号： C25D5/02

CPC分类号： C25D7/04 ,  C25D17/004

摘要： A plating method for pre-plating or plating a cylinder inner peripheral surface to be treated of a cylinder block by introducing treatment liquid to the cylinder inner peripheral surface by using a plating apparatus provided with a sealing jig having a sealing member and an electrode to which the seal jig is mounted includes the steps, which are performed successively: sealing the cylinder inner peripheral surface by bringing the sealing jig into contact with the cylinder inner peripheral surface; introducing the treatment liquid to the cylinder inner peripheral surface; and treating the cylinder inner peripheral surface by applying predetermined charge to the electrode of the plating apparatus and the cylinder block to thereby perform pre-plating or plating process in a state that a liquid to be treated fills a space including the cylinder inner peripheral surface. In the method, the treatment liquid introducing step is performed after confirmation of sealing by the sealing step.

摘要翻译： 一种电镀方法，用于通过使用具有密封构件和电极的电镀装置将处理液引入到缸体内周面来对汽缸体进行处理的汽缸内周面进行电镀或电镀， 安装密封夹具包括依次执行的步骤：通过使密封夹具与气缸内周面接触来密封气缸内周面; 将处理液引入气缸内周面; 以及通过向镀覆设备和气缸体的电极施加预定的电荷来处理气缸内周面，从而在待处理的液体填充包括气缸内周面的空间的状态下进行预镀或电镀处理。 在该方法中，在通过密封步骤确认密封之后进行处理液引入步骤。

公开(公告)号：US08152487B2

公开(公告)日：2012-04-10

申请号：US12442049

申请日：2008-09-18

申请人： Takayuki Watanabe ,  Manabu Suzuki ,  Yuki Ichise ,  Yukihiro Sakaguchi ,  Takeshi Hirano ,  Akinori Yoshioka ,  Takayuki Hagita

发明人： Takayuki Watanabe ,  Manabu Suzuki ,  Yuki Ichise ,  Yukihiro Sakaguchi ,  Takeshi Hirano ,  Akinori Yoshioka ,  Takayuki Hagita

IPC分类号： F04B17/00

CPC分类号： F04B35/04

摘要： An inverter-integrated electric compressor that is capable of solving various problems caused by thermal expansion of a gel material filled inside an inverter accommodating section for vibration prevention and moisture prevention and capable of increasing reliability is provided. In the inverter-integrated electric compressor, an inverter accommodating section (11) is integrated with a periphery of a housing (2) accommodating an electric compressor; an inverter device (20) is accommodated inside the inverter accommodating section; a gel material (30) for vibration prevention and moisture prevention is filled in the upper section thereof so as to leave an air layer (31); an upper opening in the inverter accommodating section is sealed with a cover member (18); and a vent valve (40) formed of a moisture-permeable waterproof membrane (42) is provided in the cover member.

摘要翻译： 提供了能够解决填充在用于防振防潮的逆变器容纳部内部的凝胶材料的热膨胀引起的并且能够提高可靠性的各种问题的逆变器一体式电动压缩机。 在逆变器一体式电动压缩机中，逆变器容纳部（11）与容纳电动压缩机的壳体（2）的周围一体化; 逆变器装置（20）容纳在逆变器容纳部内部; 用于防止和防潮的凝胶材料（30）被填充在其上部以留下空气层（31）; 逆变器容纳部的上部开口用盖部件（18）密封。 并且在所述盖构件中设置由透湿性防水膜（42）形成的排气阀（40）。

公开(公告)号：US20100226800A1

公开(公告)日：2010-09-09

申请号：US12227942

申请日：2008-09-25

申请人： Yuki Ichise ,  Takayuki Watanabe ,  Manabu Suzuki ,  Ichiro Yogo ,  Noriaki Arashi

发明人： Yuki Ichise ,  Takayuki Watanabe ,  Manabu Suzuki ,  Ichiro Yogo ,  Noriaki Arashi

IPC分类号： F04B35/04

CPC分类号： B60H1/00978 ,  B60H2001/00621 ,  F04B35/04 ,  F04B53/16

摘要： Provided is a vehicle electric compressor in which damage, such as damage to the function of an inverter unit or a high-voltage cable, is less likely to occur even when an external force is applied. A vehicle electric compressor (10) in which a compressing mechanism for compressing and discharging intake fluid and an electric motor for driving the compressing mechanism are accommodated in a housing (11), and an inverter unit (14) for rotational control of an electric motor is disposed on the outside of the housing (11), wherein a cover member (20) for protecting the inverter unit (14) from an external force is provided on the outside of the inverter unit (14).

摘要翻译： 提供了即使施加外力也不太可能发生诸如损坏逆变器单元或高压电缆的损坏的车辆电动压缩机。 一种车辆电动压缩机（10），其中用于压缩和排出进气流体的压缩机构和用于驱动压缩机构的电动机容纳在壳体（11）中，并且用于电动机的旋转控制的逆变器单元（14） 设置在壳体（11）的外侧，在逆变器单元（14）的外侧设置有用于保护逆变器单元（14）不受外力的盖构件（20）。

公开(公告)号：US20100018244A1

公开(公告)日：2010-01-28

申请号：US12442049

申请日：2008-09-18

申请人： Takayuki Watanabe ,  Manabu Suzuki ,  Yuki Ichise ,  Yukihiro Sakaguchi ,  Takeshi Hirano ,  Akinori Yoshioka ,  Takayuki Hagita

发明人： Takayuki Watanabe ,  Manabu Suzuki ,  Yuki Ichise ,  Yukihiro Sakaguchi ,  Takeshi Hirano ,  Akinori Yoshioka ,  Takayuki Hagita

IPC分类号： F25B31/02 ,  B60H1/32 ,  F04B35/04

CPC分类号： F04B35/04

摘要： An inverter-integrated electric compressor that is capable of solving various problems caused by thermal expansion of a gel material filled inside an inverter accommodating section for vibration prevention and moisture prevention and capable of increasing reliability is provided. In the inverter-integrated electric compressor, an inverter accommodating section (11) is integrated with a periphery of a housing (2) accommodating an electric compressor; an inverter device (20) is accommodated inside the inverter accommodating section; a gel material (30) for vibration prevention and moisture prevention is filled in the upper section thereof so as to leave an air layer (31); an upper opening in the inverter accommodating section is sealed with a cover member (18); and a vent valve (40) formed of a moisture-permeable waterproof membrane (42) is provided in the cover member.

摘要翻译： 提供了能够解决填充在用于防振防潮的逆变器容纳部内部的凝胶材料的热膨胀引起的并且能够提高可靠性的各种问题的逆变器一体式电动压缩机。 在逆变器一体式电动压缩机中，逆变器容纳部（11）与容纳电动压缩机的壳体（2）的周围一体化; 逆变器装置（20）容纳在逆变器容纳部内部; 用于防止和防潮的凝胶材料（30）被填充在其上部以留下空气层（31）; 逆变器容纳部的上部开口用盖部件（18）密封。 并且在所述盖构件中设置由透湿性防水膜（42）形成的排气阀（40）。