公开(公告)号：US20170333690A1

公开(公告)日：2017-11-23

申请号：US15532836

申请日：2015-12-04

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Makoto OGURA ,  Naoki YAMAMOTO ,  Takashi KUMON

IPC: A61M37/00

Abstract: A microneedle device system includes a microneedle device having a sheet-like microneedle having a sheet in which one surface is a skin contact surface and the other surface is a rear surface, and in which a plurality of microneedles are formed substantially along a surface of the sheet, and in which the microneedles in the skin piercing region are raised from the skin contact surface so as to be capable of piercing skin if the sheet is bent in a thickness direction, an adhesive layer that is disposed on the sheet-like microneedle, and a liner that is attached to the adhesive layer so as to be releasable therefrom, and an auxiliary tool having a bending portion which bends the microneedle device in the thickness direction, and on which the microneedle device is mounted so as to be movable along the bending portion.

公开(公告)号：US20150314117A1

公开(公告)日：2015-11-05

申请号：US14654029

申请日：2013-11-27

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Shunsuke ARAMI ,  Makoto OGURA ,  Seiji TOKUMOTO

IPC: A61M37/00

CPC classification number: A61M37/0015 ,  A61K9/0021 ,  A61M5/1454 ,  A61M2005/14506 ,  A61M2005/1585 ,  A61M2037/0023 ,  A61M2037/0046

Abstract: An applicator includes a piston plate, a non-linear coil spring, a casing, a lock means and a release means. The casing includes a tubular main body part that houses therein the piston plate and the non-linear coil spring, and a cover part that is arranged on one end side of the main body part. The cover part and the piston plate sandwich the non-linear coil spring there between. The lock means locks the piston plate with the casing such that the piston plate is held at a retraction position thereof on the cover part side in a state where the cover part and the piston plate compress the non-linear coil spring. The release means releases a locked state where the piston plate is locked with the casing by the lock means and where the cover part and the piston plate compress the non-linear coil spring.

Abstract translation: 施加器包括活塞板，非线性螺旋弹簧，壳体，锁定装置和释放装置。 壳体包括容纳活塞板和非线性螺旋弹簧的管状主体部分和布置在主体部分的一端侧的盖部分。 盖部分和活塞板夹在其间的非线性螺旋弹簧。 锁定装置将活塞板与壳体锁定，使得活塞板在盖部分和活塞板压缩非线性螺旋弹簧的状态下在盖部分侧保持在其缩回位置。 释放装置释放锁定状态，其中活塞板通过锁定装置与壳体锁定，并且盖部分和活塞板压缩非线性螺旋弹簧。

公开(公告)号：US20150374967A1

公开(公告)日：2015-12-31

申请号：US14767138

申请日：2014-02-12

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Ryusuke FUDOJI ,  Makoto OGURA

IPC: A61M37/00

CPC classification number: A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0053 ,  A61M2037/0061

Abstract: A microneedle array in accordance with one embodiment comprises at least a first microneedle and a second microneedle that are inclined with respect to a support face. A tip of the first microneedle points in a first direction, and a tip of the second microneedle points in a second direction different from the first direction. The first microneedle in contact with skin is stuck into the skin while being moved along a surface of the skin in the first direction. The second microneedle in contact with the skin is stuck into the skin while being moved along the surface of the skin in the second direction.

Abstract translation: 根据一个实施例的微针阵列至少包括相对于支撑面倾斜的第一微针和第二微针。 第一微针的尖端指向第一方向，并且第二微针的尖端指向与第一方向不同的第二方向。 与皮肤接触的第一微针在沿着第一方向沿着皮肤表面移动的同时被粘贴到皮肤中。 与皮肤接触的第二微针在沿着第二方向沿着皮肤表面移动的同时被粘贴到皮肤中。

公开(公告)号：US20160263363A1

公开(公告)日：2016-09-15

申请号：US15032709

申请日：2014-11-04

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Shunsuke ARAMI ,  Shinpei NISHIMURA ,  Seiji TOKUMOTO ,  Makoto OGURA

IPC: A61M37/00

CPC classification number: A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0061

Abstract: An applicator is configured to transfer an active ingredient into a body through skin by a puncture in the skin with microneedles. The applicator includes a piston plate that is provided with a first protrusion part and second protrusion parts on a lower surface side of a main body of the piston plate. The microneedles are provided on a surface of the first protrusion part. The second protrusion parts are provided in a periphery of the first protrusion part while spaced apart from the first protrusion part.

Abstract translation: 施用器被构造成通过皮肤用皮肤穿刺用微针将活性成分转移到皮肤中。 涂抹器包括活塞板，活塞板在活塞板的主体的下表面侧设置有第一突出部和第二突出部。 微针设置在第一突出部的表面上。 第二突起部分设置在与第一突出部分间隔开的第一突出部分的周边。

公开(公告)号：US20160144160A1

公开(公告)日：2016-05-26

申请号：US14899148

申请日：2014-06-17

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Naoki YAMAMOTO ,  Makoto OGURA

IPC: A61M37/00

CPC classification number: A61M37/0015 ,  A61M2037/0023

Abstract: An applicator of one aspect for applying microneedles to skin includes a resistive portion configured to apply resistance against movement of a microneedle sheet having the plurality of microneedles formed along a main surface of the sheet, and a bending portion configured to bend the microneedle sheet passed through the resistive portion to raise the microneedle from the main surface.

Abstract translation: 用于将微针施加到皮肤的一个方面的涂抹器包括电阻部分，其被构造成施加抵抗沿着所述片材的主表面形成的具有多个微针的微针片的运动的阻力;以及弯曲部分，其被配置为弯曲经过的微针片 电阻部分，用于将微针从主表面上升。

公开(公告)号：US20160136405A1

公开(公告)日：2016-05-19

申请号：US14899146

申请日：2014-06-17

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Naoki YAMAMOTO ,  Makoto OGURA

IPC: A61M37/00

CPC classification number: A61M37/0015 ,  A61M25/002 ,  A61M35/00 ,  A61M37/00 ,  A61M2025/0266 ,  A61M2037/0023

Abstract: An applicator of one aspect for applying a sheet member to skin includes a body having a bottom surface facing the skin and a first guide configured to guide the sheet member to a space between the skin and the bottom surface, in which the sheet member is applied to the skin after being folded in the space.

Abstract translation: 用于将片材构件施加到皮肤的一个方面的施加器包括具有面向皮肤的底表面的主体和被构造成将片材引导到皮肤和底表面之间的空间的第一引导件，其中应用片材构件 在空间中折叠后的皮肤。

公开(公告)号：US20190015652A1

公开(公告)日：2019-01-17

申请号：US16134030

申请日：2018-09-18

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Kazuya KOMINAMI ,  Shinpei NISHIMURA ,  Seiji TOKUMOTO ,  Makoto OGURA ,  Toshiyuki MATSUDO ,  Naoki YAMAMOTO

IPC: A61M37/00 ,  A61N2/00 ,  A61N1/32

Abstract: A microneedle sheet according to an embodiment comprises a plurality of microneedles formed on a sheet substantially along a principal surface of the sheet. The sheet is bent to raise the microneedles from the principal surface, and the raised microneedles pierce a skin.

公开(公告)号：US20170049695A1

公开(公告)日：2017-02-23

申请号：US15119983

申请日：2015-02-19

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Naoki YAMAMOTO ,  Makoto OGURA

IPC: A61K9/00

Abstract: A microneedle sheet according to an embodiment includes a plurality of microneedles formed on a sheet generally along a principal surface of the sheet. The material of the microneedles is selected from among hydroxypropyl methylcellulose, hydroxypropyl cellulose, polyvinyl alcohol, and a graft copolymer of polyvinyl alcohol and polyethylene glycol. The microneedles are raised from the principal surface by bending the sheet, and the raised microneedles pierce skin.

Abstract translation: 根据一个实施方式的微针片包括多个形成在片材的主表面上的片材上的微针。 微针的材料选自羟丙基甲基纤维素，羟丙基纤维素，聚乙烯醇和聚乙烯醇与聚乙二醇的接枝共聚物。 微针通过弯曲片材从主表面凸起，并且凸起的微针刺穿皮肤。

公开(公告)号：US20160206866A1

公开(公告)日：2016-07-21

申请号：US14916354

申请日：2014-09-03

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Naoki YAMAMOTO ,  Makoto OGURA

IPC: A61M37/00

CPC classification number: A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0038 ,  A61M2037/0053

Abstract: A microneedle sheet in an embodiment of the present invention includes a plurality of microneedles formed on a sheet generally along a principal surface of the sheet. The microneedles are configured to rise from the principal surface when the sheet is bent, and the raised microneedles pierce skin. At least some of the microneedles each have a region for exposing a tear formed in the skin in a needle inserted state.

Abstract translation: 本发明的一个实施方案中的微针片包括多个形成在片材的主表面上的片材上的微针。 微针被配置成当片材弯曲时从主表面上升，并且凸起的微针刺穿皮肤。 至少一些微针每个都具有用于在针插入状态下暴露在皮肤中形成的泪液的区域。