公开(公告)号：US11590106B2

公开(公告)日：2023-02-28

申请号：US17281623

申请日：2019-09-25

Applicant: Hisamitsu Pharmaceutical Co., Inc.

Inventor： Masaki Yukuhiro ,  Yuka Takagi ,  Yasunari Michinaka

IPC: A61K31/407 ,  A61K9/70 ,  A61K47/02 ,  A61K47/12 ,  A61K47/32

Abstract: An object of the present invention is to provide an asenapine-containing patch having excellent sustained-release properties while enhancing skin permeability by using a silicone-based pressure-sensitive adhesive base. The present invention relates to a patch having a support and a pressure-sensitive adhesive layer, wherein the pressure-sensitive adhesive layer comprises asenapine and/or a pharmaceutically acceptable salt thereof, a silicone-based pressure-sensitive adhesive base and a release control agent, and the ratio of the maximum skin permeation rate of asenapine to the minimum skin permeation rate from the time when the maximum skin permeation rate is reached to 24 hours is less than 1.62.

公开(公告)号：US20210393587A1

公开(公告)日：2021-12-23

申请号：US17281623

申请日：2019-09-25

Applicant: Hisamitsu Pharmaceutical Co., Inc.

Inventor： Masaki Yukuhiro ,  Yuka Takagi ,  Yasunari Michinaka

IPC: A61K31/407 ,  A61K9/70 ,  A61K47/02 ,  A61K47/32 ,  A61K47/12

Abstract: An object of the present invention is to provide an asenapine-containing patch having excellent sustained-release properties while enhancing skin permeability by using a silicone-based pressure-sensitive adhesive base. The present invention relates to a patch having a support and a pressure-sensitive adhesive layer, wherein the pressure-sensitive adhesive layer comprises asenapine and/or a pharmaceutically acceptable salt thereof, a silicone-based pressure-sensitive adhesive base and a release control agent, and the ratio of the maximum skin permeation rate of asenapine to the minimum skin permeation rate from the time when the maximum skin permeation rate is reached to 24 hours is less than 1.62.

公开(公告)号：US11364207B2

公开(公告)日：2022-06-21

申请号：US16483511

申请日：2018-02-19

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Hideaki Ohashi ,  Takito Shima ,  Kenji Ishigaki ,  Yasunari Michinaka

IPC: A61K9/70 ,  A61K31/4045 ,  A61K47/02

Abstract: A patch comprising: a backing layer; and an adhesive layer, wherein the adhesive layer contains a mixture of a pharmaceutically acceptable acid addition salt of ropinirole and potassium hydrogen carbonate, and the mixture contains at least one selected from the group consisting of ropinirole and pharmaceutically acceptable acid addition salts thereof and potassium hydrogen carbonate.

公开(公告)号：US11020356B2

公开(公告)日：2021-06-01

申请号：US16474213

申请日：2017-12-26

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Ryo Tanaka ,  Hideaki Ohashi ,  Naruhide Miyoshi ,  Takito Shima ,  Naoko Fujita ,  Yasunari Michinaka

IPC: A61K9/70 ,  A61K31/192 ,  A61K31/196 ,  A61K31/405 ,  A61K47/12 ,  A61K47/20 ,  A61K47/32

Abstract: The patch of the present invention comprises a backing layer and an adhesive layer laminated on the backing layer, wherein a water vapor transmission rate of the backing layer is 400 g/m2·24 hours or more, and the adhesive layer comprises a drug, dimethylsulfoxide and an adhesive. Such a patch does not fall off easily even after long wear.

公开(公告)号：US10525132B2

公开(公告)日：2020-01-07

申请号：US15568432

申请日：2016-04-27

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Kana Imamura ,  Tomohiro Shinoda ,  Shingo Somekawa ,  Yasunari Michinaka

IPC: A61K47/12 ,  A61K31/216 ,  A61P17/00 ,  A61K9/00

Abstract: The present invention provides a topical preparation for treating hyperhidrosis, comprising water, an anticholinergic drug, and one or more salts selected from the group consisting of lactate, tartrate, acetate and phosphate. Such a topical preparation comprises the above certain salt, thereby facilitating the accumulation of the anticholinergic drug in skin appendages.

公开(公告)号：US10307381B2

公开(公告)日：2019-06-04

申请号：US15518847

申请日：2015-10-13

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Junji Noguchi ,  Eisuke Hatanaka ,  Hisakazu Kurita ,  Ryusuke Fudoji ,  Yasunari Michinaka

IPC: A61K31/485 ,  A61K9/70 ,  A61K47/10 ,  A61K31/00 ,  A61K47/06 ,  C08F226/02 ,  C08F226/10 ,  C08K5/092

Abstract: A patch including: a support; and an adhesive layer disposed on at least one surface of the support, in which the adhesive layer includes: at least one selected from the group consisting of butorphanol and pharmaceutically acceptable salts thereof; a higher aliphatic alcohol; and a non-cross-linking polyvinylpyrrolidone that does not contain vinyl acetate as a constituent monomer thereof.

公开(公告)号：US09789188B2

公开(公告)日：2017-10-17

申请号：US14433939

申请日：2013-10-08

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Takuya Umemoto ,  Yuka Takagi ,  Yasunari Michinaka

IPC: A61K47/12 ,  A61K31/551 ,  A61K9/70

CPC classification number: A61K47/12 ,  A61K9/7053 ,  A61K9/7061 ,  A61K9/7069 ,  A61K31/551

Abstract: A patch comprising a support layer and an adhesive agent layer, wherein the adhesive agent layer comprises at least one drug selected from the group consisting of emedastine and pharmaceutically acceptable salts thereof, at least one adhesive agent selected from the group consisting of rubber-based adhesive agents and silicone-based adhesive agents, and an alkali metal fumarate as a cohesive force-improving agent for the adhesive agent layer.

公开(公告)号：US12178922B2

公开(公告)日：2024-12-31

申请号：US17244552

申请日：2021-04-29

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Ryo Tanaka ,  Hideaki Ohashi ,  Naruhide Miyoshi ,  Takito Shima ,  Naoko Fujita ,  Yasunari Michinaka

IPC: A61K9/70 ,  A61K31/192 ,  A61K31/196 ,  A61K31/405 ,  A61K47/12 ,  A61K47/20 ,  A61K47/32

Abstract: The patch of the present invention comprises a backing layer and an adhesive layer laminated on the backing layer, wherein a water vapor transmission rate of the backing layer is 400 g/m2·24 hours or more, and the adhesive layer comprises a drug, dimethylsulfoxide and an adhesive. Such a patch does not fall off easily even after long wear.

公开(公告)号：US10716763B2

公开(公告)日：2020-07-21

申请号：US15565864

申请日：2016-04-15

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Naoyuki Uchida ,  Yasunari Michinaka

IPC: A61K9/70 ,  A61K47/18 ,  A61K31/4045

Abstract: The present invention provides a patch comprising a backing and an adhesive agent layer laminated on the backing, wherein the adhesive agent layer comprises ropinirole or a pharmaceutically acceptable salt thereof, an organic amine or an acid addition salt thereof, and an adhesive agent.

公开(公告)号：US20150250877A1

公开(公告)日：2015-09-10

申请号：US14433939

申请日：2013-10-08

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Takuya Umemoto ,  Yuka Takagi ,  Yasunari Michinaka

IPC: A61K47/12 ,  A61K31/551 ,  A61K9/70

CPC classification number: A61K47/12 ,  A61K9/7053 ,  A61K9/7061 ,  A61K9/7069 ,  A61K31/551

Abstract: A patch comprising a support layer and an adhesive agent layer, wherein the adhesive agent layer comprises at least one drug selected from the group consisting of emedastine and pharmaceutically acceptable salts thereof, at least one adhesive agent selected from the group consisting of rubber-based adhesive agents and silicone-based adhesive agents, and an alkali metal fumarate as a cohesive force-improving agent for the adhesive agent layer.

Abstract translation: 一种贴剂，其包括支持层和粘合剂层，其中所述粘合剂层包含至少一种选自依达克汀及其药学上可接受的盐的药物，至少一种选自橡胶基粘合剂 助剂和硅氧烷粘合剂，以及作为粘合剂层的内聚力改善剂的富马酸碱金属盐。