公开(公告)号：US11903915B2

公开(公告)日：2024-02-20

申请号：US17429683

申请日：2020-02-13

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Tatsuya Sakakura ,  Satoshi Kimura ,  Seiichiro Tsuru

IPC: A61K31/192 ,  A61K9/70 ,  A61K31/045 ,  A61K47/10

CPC classification number: A61K31/192 ,  A61K9/7038 ,  A61K31/045 ,  A61K47/10

Abstract: The present invention provides a gel patch having a paste layer on a support, wherein the paste layer comprising ketoprofen or a pharmaceutically acceptable salt thereof, propylene glycol, 1-menthol, and water, wherein the mass of propylene glycol in the paste layer is 3-fold the mass of ketoprofen or less, and wherein the content of 1-menthol based on a total mass of the paste layer is 0.1 to 0.5 mass %.

公开(公告)号：US09707194B2

公开(公告)日：2017-07-18

申请号：US15121534

申请日：2015-02-26

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Seiichiro Tsuru ,  Masayoshi Maki ,  Shinji Yamasoto ,  Takaaki Terahara

IPC: A61K31/192 ,  A61K9/00 ,  A61K9/70 ,  A61K31/12 ,  A61K47/10 ,  D03D15/00

CPC classification number: A61K31/192 ,  A61K9/0014 ,  A61K9/7023 ,  A61K9/7069 ,  A61K31/12 ,  A61K47/10 ,  D03D15/00

Abstract: The invention provides a gel patch comprising a support and an adhesive layer on the support, wherein the adhesive layer comprises 1.5 to 2.5 mass % of ketoprofen, 1.5 to 2.5 mass % of 4-tert-butyl-4′-methoxydibenzoylmethane and 12 to 18 mass % of propylene glycol, based on the total mass of the adhesive layer.

公开(公告)号：US10940121B2

公开(公告)日：2021-03-09

申请号：US15551916

申请日：2016-02-17

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Seiichiro Tsuru ,  Masayoshi Maki

IPC: A61K9/70 ,  A61K47/10 ,  A61K47/32 ,  A61K31/196 ,  A61K45/00 ,  A61K31/192

Abstract: A method for producing a gel patch comprising an adhesive mass layer on a backing fabric, comprising a step of applying a composition comprising a physiologically active substance, a water-soluble polymer, glycerin, and water to the backing fabric to form the adhesive mass layer, wherein a loss tangent of the composition in dynamic viscoelasticity measurement at 1 Hz at a time of application to the backing fabric is 0.75 to 1.

公开(公告)号：US10369115B2

公开(公告)日：2019-08-06

申请号：US14913455

申请日：2014-08-21

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Keiichiro Tsurushima ,  Yasuhisa Kose ,  Shinji Yamasoto ,  Seiichiro Tsuru ,  Takaaki Yoshinaga

IPC: A61K9/70 ,  A61L15/22 ,  A61L15/58 ,  A61L15/60 ,  C08L71/00 ,  C08F220/14 ,  C08L33/02

Abstract: A gel patch comprising a plaster layer on a support, the plaster layer comprising a mixture of at least a neutralized polyacrylic acid, a poly(methyl acrylate/2-ethylhexyl acrylate) emulsion, and water, wherein the poly(methyl acrylate/2-ethylhexyl acrylate) emulsion is an emulsion having an evaporation residue of 57 to 61% by heating at or above the boiling point of the medium and is present in an amount of at least 2.5 times and preferably at least 3 times the mass of the neutralized polyacrylic acid.