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公开(公告)号：US09308187B2
公开(公告)日：2016-04-12
申请号：US14408482
申请日：2013-06-17
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Inventor： Eisuke Hatanaka , Yasunori Takada , Takaaki Terahara , Naruhito Higo
IPC: A61K31/196 , A61K9/70 , A61K9/00 , A61K47/12 , A61K47/20
CPC classification number: A61K31/196 , A61K9/0014 , A61K9/7038 , A61K9/7053 , A61K9/7061 , A61K9/7069 , A61K47/12 , A61K47/20
Abstract: A patch comprising a support layer and an adhesive layer,wherein the adhesive layer comprises diclofenac sodium, dimethyl sulfoxide, and citric acid; a mass ratio between the diclofenac sodium and the citric acid (mass of diclofenac sodium:mass of citric acid) is 1:0.15 to 1:0.45; and a mass ratio between the diclofenac sodium and the dimethyl sulfoxide (mass of diclofenac sodium:mass of dimethyl sulfoxide) is 1:0.75 to 1:3.
Abstract translation: 一种贴剂，其包括支持层和粘合剂层，其中所述粘合剂层包含双氯芬酸钠，二甲基亚砜和柠檬酸; 双氯芬酸钠和柠檬酸（双氯芬酸钠的质量：柠檬酸的质量）之间的质量比为1:0.15至1:0.45; 双氯芬酸钠与二甲基亚砜（二氯苯胺酸钠的质量：二甲基亚砜的质量）的质量比为1:0.75〜1:3。
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公开(公告)号：US20140161865A1
公开(公告)日：2014-06-12
申请号：US13772843
申请日：2013-02-21
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Inventor： Naruhito Higo , Tetsurou Tateishi , Takaaki Terahara , Kazunosuke Aida , Shigeki Hayashi , Nobuo Tsutsumi
IPC: A61J3/00 , A61K31/216
CPC classification number: A61J3/00 , A61K9/7053 , A61K9/7061 , A61K31/216
Abstract: A method for producing a patch having a high skin penetrability and a high pharmaceutical physical properties such as adhesion and cohesiveness, and a long-term storability. The patch is produced by first obtaining an adhesive agent layer composition containing oxybutynin and/or salt thereof as a drug, an acrylic-based polymer and/or a rubber-based polymer as an adhesive base agent, liquid paraffin, an organic acid, and a tackifier; heating the adhesive agent layer composition at a temperature in a range from a melting point of the drug to a temperature higher than the melting point by 10° C. for 2 to 24 hours; and slowly cooling the heated adhesive agent layer composition to obtain the adhesive agent layer comprising the drug at a supersaturated concentration in a dissolved form.
Abstract translation: 一种具有高皮肤渗透性和高的药物物理性质如粘附性和内聚性以及长期保存性的贴剂的制造方法。 通过首先获得含有奥昔布宁和/或其盐作为药物的粘合剂层组合物，作为粘合剂的丙烯酸类聚合物和/或橡胶类聚合物，液体石蜡，有机酸和 增粘剂 在从药物的熔点到高于熔点10℃的温度的温度下加热粘合剂层组合物2〜24小时; 并缓慢冷却加热的粘合剂层组合物以获得以溶解形式的过饱和浓度的包含药物的粘合剂层。
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公开(公告)号：US09707194B2
公开(公告)日：2017-07-18
申请号：US15121534
申请日：2015-02-26
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Inventor： Seiichiro Tsuru , Masayoshi Maki , Shinji Yamasoto , Takaaki Terahara
CPC classification number: A61K31/192 , A61K9/0014 , A61K9/7023 , A61K9/7069 , A61K31/12 , A61K47/10 , D03D15/00
Abstract: The invention provides a gel patch comprising a support and an adhesive layer on the support, wherein the adhesive layer comprises 1.5 to 2.5 mass % of ketoprofen, 1.5 to 2.5 mass % of 4-tert-butyl-4′-methoxydibenzoylmethane and 12 to 18 mass % of propylene glycol, based on the total mass of the adhesive layer.
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公开(公告)号：US08802134B2
公开(公告)日：2014-08-12
申请号：US13772843
申请日：2013-02-21
Applicant: Hisamitsu Pharmaceutical Co., Inc.
Inventor： Naruhito Higo , Tetsurou Tateishi , Takaaki Terahara , Kazunosuke Aida , Shigeki Hayashi , Nobuo Tsutsumi
CPC classification number: A61J3/00 , A61K9/7053 , A61K9/7061 , A61K31/216
Abstract: A method for producing a patch having a high skin penetrability and a high pharmaceutical physical properties such as adhesion and cohesiveness, and a long-term storability. The patch is produced by first obtaining an adhesive agent layer composition containing oxybutynin and/or salt thereof as a drug, an acrylic-based polymer and/or a rubber-based polymer as an adhesive base agent, liquid paraffin, an organic acid, and a tackifier; heating the adhesive agent layer composition at a temperature in a range from a melting point of the drug to a temperature higher than the melting point by 10° C. for 2 to 24 hours; and slowly cooling the heated adhesive agent layer composition to obtain the adhesive agent layer comprising the drug at a supersaturated concentration in a dissolved form.
Abstract translation: 一种具有高皮肤渗透性和高的药物物理性质如粘附性和内聚性以及长期保存性的贴剂的制造方法。 通过首先获得含有奥昔布宁和/或其盐作为药物的粘合剂层组合物，作为粘合剂的丙烯酸类聚合物和/或橡胶类聚合物，液体石蜡，有机酸和 增粘剂 在从药物的熔点到高于熔点10℃的温度的温度下加热粘合剂层组合物2〜24小时; 并缓慢冷却加热的粘合剂层组合物以获得以溶解形式的过饱和浓度的包含药物的粘合剂层。
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