公开(公告)号：US10888532B2

公开(公告)日：2021-01-12

申请号：US16471692

申请日：2017-12-21

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Naoko Fujita ,  Takito Shima ,  Kazuya Kominami ,  Naoyuki Uchida

IPC: A61K9/70 ,  A61K31/485 ,  A61K47/10 ,  A61K47/14 ,  A61K47/34

Abstract: A patch comprising: a backing layer; and an adhesive layer, wherein the adhesive layer contains at least one drug selected from the group consisting of butorphanol and pharmaceutically acceptable salts thereof and a silicone-based adhesive base, and a mass per unit area of the adhesive layer is 30 to 90 g/m2.

公开(公告)号：US10716763B2

公开(公告)日：2020-07-21

申请号：US15565864

申请日：2016-04-15

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Naoyuki Uchida ,  Yasunari Michinaka

IPC: A61K9/70 ,  A61K47/18 ,  A61K31/4045

Abstract: The present invention provides a patch comprising a backing and an adhesive agent layer laminated on the backing, wherein the adhesive agent layer comprises ropinirole or a pharmaceutically acceptable salt thereof, an organic amine or an acid addition salt thereof, and an adhesive agent.

公开(公告)号：US20140170205A1

公开(公告)日：2014-06-19

申请号：US14123148

申请日：2012-05-23

Applicant: Hisamitsu Pharmaceutical Co., Inc.

Inventor： Naoyuki Uchida ,  Yuka Takagi ,  Toshiro Yamaguchi

IPC: A61K9/70 ,  A61K31/4045

CPC classification number: A61K9/7053 ,  A61K31/4045

Abstract: A ropinirole-containing patch comprises an adhesive agent layer and a support layer, the adhesive agent layer containing ropinirole and/or a pharmaceutically acceptable salt thereof, wherein a content of the ropinirole and/or the pharmaceutically acceptable salt thereof in terms of free ropinirole in the adhesive agent layer satisfies the following two conditions: 5 to 13.2% by mass relative to a total mass of the adhesive agent layer, and 0.12 to 2.7 mg/cm2 per unit area of the adhesive agent layer.

Abstract translation: 含罗匹尼罗的贴剂包含粘合剂层和支持层，所述粘合剂层含有罗匹尼罗和/或其药学上可接受的盐，其中根据游离罗哌卡罗的罗匹尼罗和/或其药学上可接受的盐的含量 粘合剂层满足以下两个条件：相对于粘合剂层的总质量为5〜13.2质量％，粘合剂层的每单位面积为0.12〜2.7mg / cm 2。

公开(公告)号：US11202764B2

公开(公告)日：2021-12-21

申请号：US16605268

申请日：2018-04-19

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Kazuya Kominami ,  Takito Shima ,  Naoyuki Uchida ,  Naoko Fujita ,  Shigeo Suzuki ,  Terumitsu Kaiho

IPC: A61K9/70 ,  A61K47/12 ,  A61P25/04 ,  A61K31/485

Abstract: A patch comprises a backing layer and an adhesive layer, wherein the adhesive layer contains at least one selected from the group consisting of butorphanol and pharmaceutically acceptable salts thereof, and contains a rubber-based adhesive base and a silicone-based adhesive base, and a mass ratio of the rubber-based adhesive base to the silicone-based adhesive base (the mass of the rubber-based adhesive base:the mass of silicone-based adhesive base) in the adhesive layer is 9.5:0.5 to 1.9:8.1.

公开(公告)号：US20220117906A1

公开(公告)日：2022-04-21

申请号：US17431303

申请日：2020-01-23

Applicant: Hisamitsu Pharmaceutical Co., Inc.

Inventor： Ryo Tanaka ,  Kazuya Kominami ,  Naoyuki Uchida ,  Takito Shima

IPC: A61K9/70 ,  A61K47/32

Abstract: The problem addressed by the present invention is to provide a method for suppressing cold flow during packaging or application, regardless of the properties or concentration of a drug, in a patch containing a drug and an acrylic adhesive base in an adhesive layer. The present invention relates to a method for suppressing cold flow of a patch equipped with a support layer and an adhesive layer containing a drug and an acrylic adhesive base, wherein the method causes calcium silicate to be contained in the adhesive layer.