公开(公告)号：US20140371693A1

公开(公告)日：2014-12-18

申请号：US14326014

申请日：2014-07-08

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.,

Inventor： Kiyomi TSURUDA ,  Shinji YAMASOTO ,  Kouki SHOHO ,  Masaru NAKANISHI

IPC: A61L15/44 ,  A61L15/58 ,  A61K31/695 ,  A61L15/24

CPC classification number: A61L15/44 ,  A61F13/00 ,  A61F15/00 ,  A61K9/7053 ,  A61K9/7076 ,  A61K31/045 ,  A61K31/618 ,  A61K31/695 ,  A61L15/24 ,  A61L15/58 ,  A61L2300/216 ,  B32B7/12 ,  Y10T428/28 ,  Y10T428/2852 ,  Y10T442/2738 ,  Y10T442/3561

Abstract: An adhesive preparation comprising a stretchable support and an adhesive layer laminated on at least one side of the support, wherein the stretchable support comprises a interlock woven fabric subjected to crimping processing, the adhesive layer contains 10% by mass or more of methyl salicylate with respect to the total mass of the layer, the whole adhesive preparation has moisture permeability of 1 to 350 g/m2·24 hr measured at a temperature of 40° C. and a relative humidity of 90%, and the methyl salicylate has a plasma AUC0-24 ranging from 3.0 to 60.0 ng·hr/mL in terms of a mean±standard deviation, and salicylic acid as a metabolite of the methyl salicylate has a plasma AUC0-24 ranging from 5000 to 13000 ng·hr/mL in terms of a mean±standard deviation, when the adhesive preparation is applied to a human skin for 8 hours such that an application amount of the adhesive layer applied is 50 to 300 g/m2 and a contact area is 280 cm2.

Abstract translation: 一种粘合剂制剂，其包含层压在所述载体的至少一侧的可拉伸载体和粘合剂层，其中所述可拉伸载体包括进行压接加工的互锁织物，所述粘合剂层包含10质量％以上的水杨酸甲酯， 相对于该层的总质量，整个粘合剂在40℃，相对湿度90％的温度下测得的透湿度为1〜350g / m 2·24小时，水杨酸甲酯的血浆AUC 0 -24的范围为3.0〜60.0ng·hr / mL，以水杨酸甲酯为代表的水杨酸的血浆AUC 0-24为5000〜13000ng·hr / mL，以 当将粘合剂制剂施用于人类皮肤8小时，使得施加的粘合剂层的施用量为50至300g / m 2，接触面积为280cm 2时，其平均值为±标准偏差。