公开(公告)号：US11427850B2

公开(公告)日：2022-08-30

申请号：US16298789

申请日：2019-03-11

Applicant: HITACHI, LTD.

Inventor： Chihiro Manri ,  Hideyuki Noda ,  Naoko Senda

IPC: C12Q1/06 ,  C12Q1/66

Abstract: Provided is a method for detecting a microorganism in a test sample containing cells, including a step of adding the sample to a microorganism culture medium, a step of culturing the microorganism culture medium containing the sample, a step of sampling a part of the culture medium at a predetermined time, a step of acquiring the ATP level of the sampled culture medium, and a step of detecting the microorganism in the sample based on the change of the ATP level over time.

公开(公告)号：US11162903B2

公开(公告)日：2021-11-02

申请号：US16740048

申请日：2020-01-10

Applicant: HITACHI, LTD.

Inventor： Shunsuke Kawabe ,  Yuichi Uchiho ,  Hideyuki Noda

IPC: G01N21/76 ,  G01N35/02 ,  G01N21/11 ,  G01N35/10 ,  G01N21/64 ,  G01N33/58

Abstract: An apparatus, system, and method for performing an efficient luminescence measurement are disclosed. The apparatus comprises a nozzle for dispensing a luminescent reagent into a well W in a microplate M, a luminescence measurement unit for measuring luminescence occurring in the well W caused by mixing of the luminescent reagent and a specimen, and a stage (moving unit) for moving the nozzle and the luminescence measurement unit together vertically and horizontally, wherein the nozzle is secured to the stage and the luminescence measurement unit is mounted to be movable vertically with respect to the stage through a holder and springs interposed between the luminescence measurement unit and the holder.

公开(公告)号：US10481098B2

公开(公告)日：2019-11-19

申请号：US15547910

申请日：2015-04-30

Applicant: Hitachi, Ltd.

Inventor： Masahiro Okanojo ,  Hideyuki Noda

IPC: G01N21/76 ,  G01N35/02 ,  G01N35/04 ,  C12Q1/02 ,  G01N35/00 ,  G01N35/10

Abstract: A luminometer apparatus includes, inside a light-shielded room, a container rack loaded with holding containers, a dispensation mechanism that dispenses a liquid, a rotary plate that turns, while holding a plurality of reaction containers which accommodate a mixture liquid of a sample and a luminescent reagent on a concentric annular plate, and is provided with a gap allowing the container rack to pass therethrough between at least a pair of adjacent ones of the reaction containers, and a photodetection unit that performs luminescence measurements. The light-shielded room has an insertion opening having a width allowing for insertion of the container rack and provided to be openable and closable. The rotary plate is provided with a region in which the container rack can be installed inside a region of passage of the reaction containers, when turning, and is provided to be turnable where the light-shielded room is in a closed state.

公开(公告)号：US10323266B2

公开(公告)日：2019-06-18

申请号：US15557017

申请日：2015-03-17

Applicant: Hitachi, Ltd.

Inventor： Hideyuki Noda ,  Hiroko Tada ,  Chihiro Uematsu ,  Masahiro Okanojo

IPC: C12Q1/18 ,  C12Q1/66 ,  C12M1/00 ,  C12M1/12 ,  C12M1/34 ,  C12M3/00 ,  G01N21/76

Abstract: Provided is a antimicrobial susceptibility testing device, including: an ATP examination culture plate that includes a reaction vessel, a reagent holding parts for holding reagents to be supplied to the reaction vessel, and a culture solution holding part for holding a culture solution to be supplied to the reaction vessel, and has plural layers that can be joined and separated; a gas feeding path for feeding a gas into the ATP examination culture plate; a heater; an optical detection unit; and a determination unit for determining sensitivity of a bacterial strain contained in the culture solution to a drug based on a detection result of the optical detection unit, wherein when the plural layers of the ATP examination culture plate are joined, at least the culture solution holding part and the reaction vessel are in a sealed state while communicating with each other.

公开(公告)号：US08778265B2

公开(公告)日：2014-07-15

申请号：US13689145

申请日：2012-11-29

Applicant: Hitachi, Ltd.

Inventor： Hideyuki Noda ,  Satoshi Ozawa ,  Masahiro Okanojo ,  Kenko Uchida

IPC: G01N21/76

CPC classification number: C12Q1/04 ,  G01N21/76

Abstract: An apparatus includes a system for guiding chemiluminescence and a system for preventing a variation in dark currents. The apparatus includes a first light shielding BOX having a sample container holder and a shutter unit therein, the shutter unit including a top plate which is partly formed by a movement of a plate member, and a second light shielding BOX having a photodetector therein. While a measurement is not implemented, the shutter unit is closed to block entrance of stray light to the photodetector, and while a measurement is implemented, the plate member is moved to open the shutter unit, and the tip of the photodetector is inserted into a through hole formed in the top plate, so that the distance between the bottom of the sample container and a sensitive area of the photodetector is reduced to several millimeters or less.

Abstract translation: 一种装置包括用于引导化学发光的系统和用于防止暗电流变化的系统。 该装置包括：第一遮光箱，其具有样本容器保持器和其中的快门单元，所述快门单元包括部分地由板构件的运动形成的顶板和在其中具有光电检测器的第二遮光箱。 虽然没有实现测量，但是快门单元被关闭以阻止杂散光入射到光电检测器，并且在实现测量的同时，移动板构件以打开快门单元，并且将光电检测器的末端插入到 通孔形成在顶板中，使得样品容器的底部与光电检测器的敏感区域之间的距离减小到几毫米或更小。