公开(公告)号：US3810915A

公开(公告)日：1974-05-14

申请号：US25655572

申请日：1972-05-24

申请人： HOFFMANN LA ROCHE

发明人： FURST A ,  BUCHSCHACHER P ,  MEIER W ,  WIDMER E ,  KAGI D ,  MULLER M

IPC分类号： C07C59/215 ,  C07D311/94 ,  C07D317/26 ,  C07D317/30 ,  C07D493/10 ,  C07D13/04

CPC分类号： C07D493/10 ,  C07C49/443 ,  C07C49/733 ,  C07C59/215 ,  C07C69/003 ,  C07C69/78 ,  C07C2602/28 ,  C07C2603/16 ,  C07D311/94 ,  C07D317/26 ,  C07D317/30

摘要： BENZ(E)INDENE DERIVATIVES AND INTERMEDIATES THEREFOR HAVE BEEN PREPARED BY VARIOUS PROCESSES STARTING FROM HEXAHYDROINDANE DERIVATIVES. THE BENZ(E)INDENE END PRODUCTS BELONG TO A KNOWN CLASS OF COMPOUNDS AND ARE USEFUL AS INTERMEDIATES IN THE SYNTHESIS OF STEROIDAL COMPOUNDS.

公开(公告)号：US3835127A

公开(公告)日：1974-09-10

申请号：US70923968

申请日：1968-02-29

申请人： HOFFMANN LA ROCHE

发明人： FURST A ,  FURLENMEIER A ,  WIECHERT R ,  HOCKS P ,  KERB U ,  LANGEMANN A ,  WALDVOGEL G

IPC分类号： C07J9/00 ,  C07C173/00

CPC分类号： C07J9/00

摘要： This invention is directed to 2,3-substituted-20-hydrocarbyl 6keto-steroids which are useful as metamorphosis hormones and are additionally useful as intermediates for the production of other insect hormones. Accordingly, the compounds may be employed in the control of insect population.

摘要翻译： 本发明涉及可用作变态激素的2,3-取代的20-烃基6-酮类固醇，并且还可用作生产其它昆虫激素的中间体。 因此，这些化合物可用于防治昆虫群体。

公开(公告)号：US3828062A

公开(公告)日：1974-08-06

申请号：US13409171

申请日：1971-04-14

申请人： HOFFMANN LA ROCHE

发明人： SCOTT J ,  WIDMER E ,  MEIER W ,  MULLER P ,  FURST A ,  LABLER L

IPC分类号： A61K31/5685 ,  C07J1/00 ,  C07J15/00 ,  C07D85/00

CPC分类号： A61K31/5685 ,  C07J1/00 ,  C07J15/00

摘要： DESA-9B-STEROIDS ARE PRODUCED BY THE HYDROGENATION OF DESA->9 STEROIDS USING A PALLIDIUM CATALYST IN THE PRESENCE OF HYDROBRONIC ACID. THESE COMPOUNDS ARE USEFUL INTERMEDIATES FOR THE PREPARATION OF HORMONALLY ACTIVE 9B,10ASTEROIDS.

公开(公告)号：US3766213A

公开(公告)日：1973-10-16

申请号：US3766213D

申请日：1971-01-06

申请人： HOFFMANN LA ROCHE

发明人： USKOKOVIC M ,  FURST A ,  KOCH W

IPC分类号： C07C59/205 ,  C07C59/215 ,  C07D7/26

CPC分类号： C07C59/205 ,  C07C59/215 ,  C07C2603/16 ,  C07J15/005 ,  C07J75/005

摘要： A PROCESS FOR PRODUCING KNOWN RETROSTEROIDS OF THE FORMULA:

1-R1,2-R2,3-(O=),4-R4,6-R6,7-R7,11-R11,16-R16-ANDROST-4-

ENE WHERE C17 IS Z

WHEREIN: R1 IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, LOWER ALKYL, LOWER ALKOXY, AND LOWER ALKYLTHIO; R2 IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, LOWER ALKYL, LOWER ALKOXY, AND LOWER ALKYLTHIO; R6 IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, LOWER ALKYL, LOWER ALKYLTHIO, LOWER AKLANOYLTHIO, AND HALO; R7 IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, LOWER ALKYL, LOWER ALKYLTHIO, LOWER ALKANOYLTHIO, AND HALO; R11 IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, HYDROXY AND LOWER ALKANOYLOXY; R16 IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, LOWER ALKYL, HYDROXY, LOWER ALKOXY, LOWER ALKANOYLOXY, AND, WHEN THE 17B-SUBSTITUENT IS ACETYL OR SUBSTITUTED ACETYL, FLUORINE; Z IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF CARBONYL, (17B-HYDROXY-17-A-LOWER ALKANOIC ACID LACTONE), AND

>C(-R17ALPHA)-R17BETA

R17B IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF HYDROXY, LOWER ALKANOYLOXY, AND

Y-CH2-CO-

Y IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, HALO, AND HYDROXY; R17A, WHEN R17B IS HYDROXY AND LOWER ALKANOYLOXY, IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF HYDROGEN AND LOWER ALIPHATIC HYDROCARBYL, AND WHEN R17B IS

Y-CH2-CO-

IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF HYDROGEN ALKYL, HYDROXY, LOWER ALKANOYLOXY, AND HALO; Q WHEN TAKEN ALONE, IS OXO; T1 WHEN TAKEN ALONE, IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF ALKALI METAL OXY AND LOWER ALKOXY; AND T1 AND Q, WHEN TAKEN TOGETHER ARE NITROLO.