公开(公告)号：US3795678A

公开(公告)日：1974-03-05

申请号：US3795678D

申请日：1972-11-21

申请人： HOFFMANN LA ROCHE

发明人： BOLLAG W ,  GUTMANN H ,  HEGEDUS B ,  MULLER M ,  ZELLER P ,  KAISER A ,  LANGEMANN A

IPC分类号： C07C51/60 ,  C07C233/00 ,  C07C243/38 ,  C07D213/81 ,  C07D213/82 ,  C07D261/18 ,  C07D307/14 ,  C07D307/52 ,  C07D317/58 ,  C07D31/44

CPC分类号： C07D213/81 ,  C07C51/60 ,  C07C233/00 ,  C07C243/00 ,  C07C243/38 ,  C07D213/82 ,  C07D261/18 ,  C07D307/14 ,  C07D307/52 ,  C07D317/58 ,  Y02P20/55 ,  C07C63/10

摘要： BENZENE-RING SUBSTITUTED (2-METHYLHYDRAZINO)-METHYLBENZENE COMPOUNDS AND INTERMEDIATES THEREFOR ARE DESCRIBED. THE FORMER COMPOUNDS ARE USEFUL AS CYTOSTATIC AGENTS AND, PARTICUARLY, INHIBIT THE GROWTH OF TRANSPLANTABLE TUMORS IN BOTH MICE AND RATS. THUS, THEY ARE ACTIVE, FOR EXAMPLE, AGAINST WALKER TUMORS, EHRLICH CARCINOMA AND EHRLICH ASCITES CARCINOMA.

公开(公告)号：US3810915A

公开(公告)日：1974-05-14

申请号：US25655572

申请日：1972-05-24

申请人： HOFFMANN LA ROCHE

发明人： FURST A ,  BUCHSCHACHER P ,  MEIER W ,  WIDMER E ,  KAGI D ,  MULLER M

IPC分类号： C07C59/215 ,  C07D311/94 ,  C07D317/26 ,  C07D317/30 ,  C07D493/10 ,  C07D13/04

CPC分类号： C07D493/10 ,  C07C49/443 ,  C07C49/733 ,  C07C59/215 ,  C07C69/003 ,  C07C69/78 ,  C07C2602/28 ,  C07C2603/16 ,  C07D311/94 ,  C07D317/26 ,  C07D317/30

摘要： BENZ(E)INDENE DERIVATIVES AND INTERMEDIATES THEREFOR HAVE BEEN PREPARED BY VARIOUS PROCESSES STARTING FROM HEXAHYDROINDANE DERIVATIVES. THE BENZ(E)INDENE END PRODUCTS BELONG TO A KNOWN CLASS OF COMPOUNDS AND ARE USEFUL AS INTERMEDIATES IN THE SYNTHESIS OF STEROIDAL COMPOUNDS.

公开(公告)号：US3711543A

公开(公告)日：1973-01-16

申请号：US3711543D

申请日：1970-06-04

申请人： HOFFMANN LA ROCHE

发明人： BOLLAG W ,  GUTMANN H ,  LANGEMANN A ,  MULLER M ,  HEGEDUS B ,  KAISER A ,  ZELLER P

IPC分类号： C07C51/60 ,  C07C233/00 ,  C07C243/38 ,  C07D213/81 ,  C07D213/82 ,  C07D261/18 ,  C07D307/14 ,  C07D307/52 ,  C07D317/58 ,  C07C127/16

CPC分类号： C07D213/81 ,  C07C51/60 ,  C07C233/00 ,  C07C243/00 ,  C07C243/38 ,  C07D213/82 ,  C07D261/18 ,  C07D307/14 ,  C07D307/52 ,  C07D317/58 ,  Y02P20/55 ,  C07C63/10

摘要： Benzene-ring substituted (2-methylhydrazino)-methyl-benzene compounds and intermediates therefore are described. The former compounds are useful as cytostatic agents and, particularly, inhibit the growth of transplantable tumors in both mice and rats. Thus, they are active, for example, against Walker tumors, Ehrlich carcinoma and Ehrlich ascites carcinoma.

公开(公告)号：US3830840A

公开(公告)日：1974-08-20

申请号：US30862872

申请日：1972-11-21

申请人： HOFFMANN LA ROCHE

发明人： ZELLER P ,  LANGEMANN A ,  MULLER M ,  HEGEDUS B ,  KAISER A ,  BOLLAG W ,  GUTMANN H

IPC分类号： C07C311/02 ,  C07C143/74

CPC分类号： C07C243/00

摘要： BEBZENE-RING SUBSTITUTED (2-METHYLHYDRAZINO)-METHYLBENZENE COMPOUNDS AND INTERMEIATES THEREOF ARE DESCRIBED. THE FORMED COMPOUNDS ARE USEFUL AS CYTOSTATIC AGENTS AND, PARTICULARLY, INIBIT THE ROOWTH OF TRANSPLANTALE TUMORS IN BOTH MICE AND RATS. THUS, THENY ARE ACTIVE FOR EXAMPLE, AGAINST WALKER TUMORS, ERLICH CARCINMA AND ERILICH ASCITES CARINOMA.

公开(公告)号：US3824288A

公开(公告)日：1974-07-16

申请号：US30862772

申请日：1972-11-21

申请人： HOFFMANN LA ROCHE

发明人： ZELLER P ,  LANGEMANN A ,  MULLER M ,  HEGEDUS B ,  KAISER A ,  BOLLAG W ,  GUTMANN H

IPC分类号： C07C233/00 ,  C07C243/38 ,  C07C129/08

CPC分类号： C07C243/38 ,  C07C233/00 ,  C07C243/00

摘要： BENZENE-RING SUBSTITUTED (2-METHYLHYDRAZINO)-METHYLBENZENE COMPOUNDS AND INTERMEDIATES THEREFOR ARE DESCRIBED. THE FORMER COMPOUNDS ARE USEFUL AS CYTOSTATIC AGENTS AND, PARTICULARLY, IN HIBIT THE GROWTH OF TRANSPLANTABLE TOUMORS IN BOTH MICE AND RATS. THUS, THEY ARE ACTIVE, FOR EXAMPLE,AGAINST WALKER TUMORS, EHRILICH CARCINOMA AND EHRILICH ASCITES CARCINOMA.