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公开(公告)号：US3502776A
公开(公告)日：1970-03-24
申请号：US3502776D
申请日：1969-04-17
Applicant: HOFFMANN LA ROCHE
Inventor： HOFFER MAX , MITROVIC MILAN
IPC: A23K1/16 , C07D233/92 , A61K27/00
CPC classification number: C07D233/92 , A23K20/137
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公开(公告)号：US3868373A
公开(公告)日：1975-02-25
申请号：US31746772
申请日：1972-12-21
Applicant: HOFFMANN LA ROCHE
Inventor： HOFFER MAX
CPC classification number: C07H13/08 , C07F7/1804 , C07H19/06
Abstract: 4-Amino-5-fluoro-2-triloweralkylsilyloxypyrimidines, useful as an intermediate in the production of antibacterial and antiviral, 1- Beta -D-arabinofuranosyl-5-fluorocytosine from fluorocytosine.
Abstract translation: 4-氨基-5-氟-2-三氟烷基甲硅烷氧基嘧啶，可用作生产抗细菌和抗病毒药物的中间体，来自氟胞嘧啶的1-β-D-阿拉伯呋喃糖基-5-氟胞嘧啶。
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3.发明授权
公开(公告)号：US3634446A
公开(公告)日：1972-01-11
申请号：US3634446D
申请日：1969-10-06
Applicant: HOFFMANN LA ROCHE
Inventor： HOFFER MAX , MITROVIC MILAN
IPC: C07D233/92 , C07D49/36
CPC classification number: C07D233/92
Abstract: THE PREPARATION OF 1-METHYL-2-ISOPROPYL-5-NITROIMIDAZOLE BY NITRATION OF 2-SIOPROPYLIMIDAZOLE TO FORM THE 2ISOPROYL-4(OR 5)-NITROIMIDAZOLE INTERMEDIATE WHICH THEN IS METHYLATED IS DISCLOSED. THE WATER SOLUBLE SALTS THEREOF ARE PREPARED BY REACTING WITH THE APPROPRIATE ACID. THE PRODUCTS HAVE ANT-HISTOMONAS AND ANTITRICHOMONAS PROPERTIES. COMPOSITIONS CONTAINING THE ACTIVE INGREDIENT ARE ALSO DISCLOSED.
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4.发明授权Compositions containing a sulfanilamide and a 2,4-diamino-5-(2',4',5'-trisubstitutedbenzyl)pyrimidine 失效含有磺酰胺和2,4-二氨基-5-（2'，4'，5'-TRISUBSTITUTEDBENZYL）吡嗪的组合物
公开(公告)号：US3461206A
公开(公告)日：1969-08-12
申请号：US3461206D
申请日：1965-06-02
Applicant: HOFFMANN LA ROCHE
Inventor： HOFFER MAX , MITROVIC MILAN
IPC: A23K1/16 , A23K1/18 , A61K31/00 , A61K31/505 , A61K31/635 , C07C255/53 , C07D239/30 , C07D239/48 , C07D239/49 , C07D239/54 , C07D239/553 , A61K27/00
CPC classification number: C07D239/30 , A23K20/137 , A61K31/00 , A61K31/505 , A61K31/635 , C07C255/00 , C07D239/49 , C07D239/54 , C07D239/553 , A61K2300/00
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公开(公告)号：US3435049A
公开(公告)日：1969-03-25
申请号：US3435049D
申请日：1965-05-19
Applicant: HOFFMANN LA ROCHE
Inventor： HOFFER MAX
IPC: C07D233/68 , C07D233/92 , C07D233/94 , C07D49/36 , A01N9/02 , C07D99/02
CPC classification number: C07D233/94 , C07D233/68 , C07D233/92
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Patent Agency Ranking
公开(公告)号：US3636039A
公开(公告)日：1972-01-18
申请号：US3636039D
申请日：1970-02-24
Applicant: HOFFMANN LA ROCHE
Inventor： GRUENMAN VSEVOLOD , HOFFER MAX
IPC: A61K31/415 , C07C45/71 , C07C47/575 , C07D233/32 , C07D49/34
CPC classification number: C07C255/00 , C07C45/71 , C07C47/575 , C07D233/32
Abstract: THE PRESENT DISCLOSURE RELATES TO NOVEL BENZYLIMIDAZOLIDINONES, WITH SPECIAL REFERENCE TO THE 4-(SUBSTITUTED BENZYL)-2-IMIDAZOLIDINONES, METHODS FOR THEIR PREPARATION AND NOVEL INTERMEDIATES USEFUL THEREIN. THE BENZYLIMIDAZOLIDINONES ARE USEFUL AS HYPOTENSIVE AGENTS.
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公开(公告)号：US3519637A
公开(公告)日：1970-07-07
申请号：US3519637D
申请日：1966-12-06
Applicant: HOFFMANN LA ROCHE
Inventor： HOFFER MAX
IPC: C07D417/06 , C07D91/34
CPC classification number: C07D417/06
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8.发明授权Preservation of organic materials from microbial attack with halogenated uracils 失效有害物质的微生物侵袭与有机化合物的保存
公开(公告)号：US3467752A
公开(公告)日：1969-09-16
申请号：US3467752D
申请日：1966-06-16
Applicant: HOFFMANN LA ROCHE
Inventor： DUSCHINSKY ROBERT , HOFFER MAX
IPC: C07D239/22 , C07D239/54 , C07D239/553 , A61L13/00 , D21H5/22
CPC classification number: C07D239/22 , C07D239/553
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公开(公告)号：US3923833A
公开(公告)日：1975-12-02
申请号：US44063874
申请日：1974-02-07
Applicant: HOFFMANN LA ROCHE
Inventor： GRUENMAN VSEVOLOD , HOFFER MAX
IPC: C07C45/71 , C07C47/575 , C07C255/32 , C07D233/32 , C07C121/66 , C07D317/60
CPC classification number: C07C255/00 , C07C45/71 , C07C47/575 , C07D233/32 , Y10S514/929 , Y10S514/937 , Y10S514/96 , Y10S514/962
Abstract: The present disclosure relates to novel benzylimidazolidinones, with special reference to the 4-(substituted benzyl)-2imidazolidinones, methods for their preparation and novel intermediates useful therein. The benzylimidazolidinones are useful as hypotensive agents.
Abstract translation: 本公开涉及新的苄基咪唑烷酮，特别涉及4-（取代的苄基）-2-咪唑烷酮，其制备方法和可用于其中的新型中间体。 苄基咪唑啉酮可用作降压剂。
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10.发明授权2,2{40 -Anhydro-1-{62 D-arabinofuranosyl-5-fluorocytosine salts and process 2 失效2,2 {40-氨氢-1- {62-阿拉伯呋喃糖基-5-氟胞嘧啶盐和方法2
公开(公告)号：US3899482A
公开(公告)日：1975-08-12
申请号：US28649172
申请日：1972-09-05
Applicant: HOFFMANN LA ROCHE
Inventor： HOFFER MAX
CPC classification number: C07H19/06
Abstract: Reaction of 5-fluorocytidine with the Vilsmeier-Haack reagent followed by treatment of the reaction mixture with water or a lower alkanol directly yields the previously unknown hydrohalide salts of 2,2''-anhydro-1- Beta -D-arabinofuranosyl-5fluorocytosine as crystalline solids. These compounds are useful as orally or parenterally active immunorepressive or antineoplastic agents and as intermediates in the preparation of other acid addition salts, such as the formate of the base compound.
Abstract translation: 5-氟胞苷与Vilsmeier-Haack试剂的反应，然后用水或低级烷醇处理反应混合物直接得到以前未知的2,2'-脱水-β-D-阿拉伯呋喃糖基-5-氟胞嘧啶氢醌盐 作为结晶固体。 这些化合物可用作口服或胃肠外有效的免疫抑制剂或抗肿瘤剂，以及作为制备其它酸加成盐的中间体，例如碱化合物的甲酸盐。
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