公开(公告)号：US3642839A

公开(公告)日：1972-02-15

申请号：US3642839D

申请日：1970-01-08

Applicant: HOFFMANN LA ROCHE

Inventor： FURST ANDOR ,  MULLER MARCEL ,  MULLER PETER

IPC: A61K31/568 ,  A61K31/5685 ,  A61K31/573 ,  C07C169/20

CPC classification number: A61K31/573 ,  A61K31/568 ,  A61K31/5685

Abstract: THE INVENTION COMPRISES 19-HOMO-STEROIDS OF THE FORMULA

17-R2,17-R3,19-R1-ESTRANE WITH R IN PLACE OF #3 CH2

HAVING UNSATURATED A AND/OR B RINGS, WHEREIN R IS A KETO, ALKOXY, HYDROXY OR ACYLOXY; R1 IS LOWER ALKYL HAVING AT LEAST 2 CARBON ATOMS OR LOWER ALKEN-1''-YL; R2 IS HALOLOWER-ALKENYL OR HALO-LOWER-ALKYNYL; AND R3 IS HYDROXY, ACYLOXY OR ALKOXY WHICH COMPOUNDS ARE USEFUL AS ANTIGONADOTROPHIC AGENTS.

公开(公告)号：US3700702A

公开(公告)日：1972-10-24

申请号：US3700702D

申请日：1970-12-02

Applicant: HOFFMANN LA ROCHE

Inventor： FURST ANDOR ,  MULLER MARCEL ,  MULLER PETER ,  SCHOCHER ARNO JOHANNES ,  BECHER ELISABETH

IPC: C07J53/00 ,  C07J75/00 ,  C07C169/32

CPC classification number: C07J53/00 ,  C07J75/00

Abstract: A new series of 15 Beta ,16 Beta -methylene pregnanes is disclosed and methods for their preparation are described. The compounds are particularly useful as antiinflammatory agents.

Abstract translation: 公开了一系列新的15β，16β-亚甲基孕烷，并描述了其制备方法。 该化合物特别可用作抗炎剂。

公开(公告)号：US3676467A

公开(公告)日：1972-07-11

申请号：US3676467D

申请日：1969-04-17

Applicant: HOFFMANN LA ROCHE

Inventor： FURST AUTOR ,  MULLER PETER ,  MULLER MARCEL ,  KAGI DIETER

IPC: A47B96/16 ,  A47L17/02 ,  A61K31/57 ,  A61K31/573 ,  C07J3/00 ,  C07J5/00 ,  C07J7/00 ,  C07J53/00 ,  C07J75/00 ,  C07C169/32 ,  C07C169/34

CPC classification number: C07J53/00 ,  A47L17/02 ,  A61K31/57 ,  A61K31/573 ,  C07J3/00 ,  C07J5/00 ,  C07J7/00 ,  C07J75/00

Abstract: Compounds of the formula

ARE DESCRIBED. The aforesaid compounds are useful as hormonal agents.

Abstract translation: 式ARE化合物描述。 上述化合物可用作激素剂。

公开(公告)号：US3644438A

公开(公告)日：1972-02-22

申请号：US3644438D

申请日：1970-03-11

Applicant: HOFFMANN LA ROCHE

Inventor： FURST ANDOR ,  KAGI DIETER ,  MULLER MARCEL ,  MULLER PETER

IPC: C07J53/00 ,  C07C169/32

CPC classification number: C07J53/00

Abstract: MEDICINALLY VALUABLE 6-METHYLI15B, 16B-METHYLENE PREGNENES ARE OBTAINED FROM NOVEL CORRESPONDINGLY SUBSTITUTED 6-HYDROXYMETHYL-15B,16B-METHYLENE PREGENES BY A TWO STEP PROCEDURE. THE 6-HYDROXYMETHYL-15B,16BMETHYLENE PREGNENES ARE OBTAINED BY TREATMENT OF A 6UNSUBSTITUTED-15B,16B-METHYLENE PREGNENE WITH FORMALDEHYDE.