公开(公告)号：US3579502A

公开(公告)日：1971-05-18

申请号：US3579502D

申请日：1967-01-16

Applicant: HOFFMANN LA ROCHE

Inventor： MULLER MARCEL ,  ZELLER PAUL

IPC: A61K31/00 ,  C07D217/14 ,  C07D217/26 ,  C07D471/04 ,  C07D53/06

CPC classification number: C07D471/04 ,  A61K31/00 ,  C07D217/14 ,  C07D217/26 ,  Y10S514/906 ,  Y10S514/96

Abstract: IN THE INSTANT CASE, THERE IS DISCLOSED VARIOUS PROCESSES FOR PREPARING 5,9,10,14B-TETRAHYDROISOQUINO(2,1-D)BENZO (F)(1,4)DIAZEPIN-6(7H)-ONES(A). IN ONE IMPORTANT PROCESS VARIATION, A 1-(O-AMINO-PHENYL)-3,4-DIHYDROISOQUINOLINE(B) IS REACTED WITH A MEMBER CAPABLE OF PROVIDING A HALO-LOWER ALKANOYL GROUP SUCH AS HALO LOWER ALKANOYL HALIDE TO GIVE A NOVEL (2H-HALO-LOWER ALKANOYL-AMINOPHENYL)(C) DERIVATIVE. C IS THEN RING CLOSED TO A NOVEL 6OXO-6,7,9,10 TETRAHYDROISOQUINO(2,1-D)BENZO(F)(1,4)DIAZEPIN-(8)-IUM(D). D IS THEN REDUCED TO A. IN ANOTHER IMPORTANT PROCESS VARIATION, B OR A 1-(ONITRO-PHENYL)-3,4-DIHYDROISOQUINOLINE IS TREATED WITH AN A-SUBSTITUTED ACETIC ACID DERIVATIVE. THE RESULTING PRODUCT IS REDUCED AND RING CLOSED AT ELEVATED TEMPERATURE TO A. COMPOUNDS A ARE USEFUL FOR PHARMACEUTICAL PURPOSES, E.G. AS SEDATIVES, AS TRANQUILIZERS, AS ANTI-CONVULSANTS AND AS MUSCLE RELAXANTS.

公开(公告)号：US3578659A

公开(公告)日：1971-05-11

申请号：US3578659D

申请日：1969-03-28

Applicant: HOFFMANN LA ROCHE

Inventor： BERNDT HANS-DETLEF ,  BUCHSCHACHER PAUL ,  EDER ULRICH ,  FURLENMEIER ANDRE ,  FURST ANDOR ,  KERB ULRICH ,  MULLER MARCEL ,  WIECHERT RUDOLF

IPC: C07J71/00 ,  C07C173/00

CPC classification number: C07J71/0057

Abstract: 18-NOR-14B-PREGNANO-(13,14-F)-HEXAHYDRO-1,4OXAZEPINES AND METHODS FOR THEIR PREPARATION ARE DESCRIBED. THESE COMPOUNDS ARE VALUABLE PHARMACEUTICALS IN THAT THEY EXHIBIT BLOOD PRESSURE REDUCING AND DIURETIC EFFECTS. THEY ALSO POSSESS A POSITIVE INOTROPE AND MYOTROPE ACTIVITY, PROMOTE THE BLOOD FLOW TO BLOOD VESSELS SURROUNDING THE HEART AND ALSO THE STROKE MINUTE VOLUME OF THE HEART.

公开(公告)号：US3481956A

公开(公告)日：1969-12-02

申请号：US3481956D

申请日：1967-05-31

Applicant: HOFFMANN LA ROCHE

Inventor： FURST ANDOR ,  MULLER MARCEL

IPC: C07J5/00 ,  C07J7/00 ,  C07J75/00 ,  C07C169/66 ,  A61K27/00

CPC classification number: C07J7/00 ,  C07J5/00 ,  C07J75/00

公开(公告)号：US3476746A

公开(公告)日：1969-11-04

申请号：US3476746D

申请日：1967-01-30

Applicant: HOFFMANN LA ROCHE

Inventor： FURST ANDOR ,  MULLER MARCEL ,  SAUCY GABRIEL

IPC: C07J1/00 ,  C07J5/00 ,  C07J75/00 ,  C07C169/66 ,  C07C167/16

CPC classification number: C07J5/00 ,  C07J1/00 ,  C07J75/00

公开(公告)号：US3700702A

公开(公告)日：1972-10-24

申请号：US3700702D

申请日：1970-12-02

Applicant: HOFFMANN LA ROCHE

Inventor： FURST ANDOR ,  MULLER MARCEL ,  MULLER PETER ,  SCHOCHER ARNO JOHANNES ,  BECHER ELISABETH

IPC: C07J53/00 ,  C07J75/00 ,  C07C169/32

CPC classification number: C07J53/00 ,  C07J75/00

Abstract: A new series of 15 Beta ,16 Beta -methylene pregnanes is disclosed and methods for their preparation are described. The compounds are particularly useful as antiinflammatory agents.

Abstract translation: 公开了一系列新的15β，16β-亚甲基孕烷，并描述了其制备方法。 该化合物特别可用作抗炎剂。

公开(公告)号：US3676467A

公开(公告)日：1972-07-11

申请号：US3676467D

申请日：1969-04-17

Applicant: HOFFMANN LA ROCHE

Inventor： FURST AUTOR ,  MULLER PETER ,  MULLER MARCEL ,  KAGI DIETER

IPC: A47B96/16 ,  A47L17/02 ,  A61K31/57 ,  A61K31/573 ,  C07J3/00 ,  C07J5/00 ,  C07J7/00 ,  C07J53/00 ,  C07J75/00 ,  C07C169/32 ,  C07C169/34

CPC classification number: C07J53/00 ,  A47L17/02 ,  A61K31/57 ,  A61K31/573 ,  C07J3/00 ,  C07J5/00 ,  C07J7/00 ,  C07J75/00

Abstract: Compounds of the formula

ARE DESCRIBED. The aforesaid compounds are useful as hormonal agents.

Abstract translation: 式ARE化合物描述。 上述化合物可用作激素剂。

公开(公告)号：US3661897A

公开(公告)日：1972-05-09

申请号：US3661897D

申请日：1970-04-14

Applicant: HOFFMANN LA ROCHE

Inventor： EDER ULRICH ,  BERNDT HANS-DETLEF ,  KERB ULRICH ,  WIECHERT RUDOLF ,  ZOLLNER GEORG ,  BUCHSCHACHER PAUL ,  FURLENMEIER ANDRE ,  FURST ANDOR ,  MULLER MARCEL

IPC: A47K10/16 ,  A61K31/57 ,  A61K31/58 ,  C07J41/00 ,  C07C173/10

CPC classification number: A61K31/57 ,  A47K10/16 ,  A61K31/58 ,  C07J41/00

Abstract: 13-METHYLAMINO STEROIDS, SALTS THEREOF AND METHODS FOR THEIR PREPARATION ARE DESCRIBED. THE AFORESAID COMPOUNDS ARE VALUABLE MEDICINALS AND EXHIBIT A GENERALLY FAVORABLE ACTIVITY ON HEART MUSCLE TONE. THEIR ACTIVITY RESULTS ESPECIALLY IN AN INCREASING OF THE EXPANDABILITY OF THE HEART MUSCLE FIBERS AND THUS FACILITATES, FOR EXAMPLE, MAKES POSSIBLE A SUFFICIENT BLOOD FILLING OF THE HEART.

公开(公告)号：US3463775A

公开(公告)日：1969-08-26

申请号：US3463775D

申请日：1967-05-03

Applicant: HOFFMANN LA ROCHE

Inventor： BOLLER ARTHUR ,  FURST ANDOR ,  MULLER MARCEL

IPC: C07J5/00 ,  C07J7/00 ,  C07J75/00 ,  C07C169/34 ,  A61K17/06

CPC classification number: C07J7/00 ,  C07J5/00 ,  C07J75/00 ,  Y02P20/55

公开(公告)号：US3927032A

公开(公告)日：1975-12-16

申请号：US45508474

申请日：1974-03-27

Applicant: HOFFMANN LA ROCHE

Inventor： FURST ANDOR ,  BUCHSCHACHER PAUL ,  KAGI DIETER ,  MEIER WERNER ,  MULLER MARCEL ,  WIDMER ERICH

IPC: C07C59/215 ,  C07D311/94 ,  C07D317/26 ,  C07D317/30

CPC classification number: C07D317/26 ,  C07C59/215 ,  C07C2602/24 ,  C07D311/94 ,  C07D317/30

Abstract: Benz(e)indene derivatives and intermediates therefore have been prepared by various processes starting from hexahydroindane derivatives. The benz(e)indene end products belong to a known class of compounds and are useful as intermediates in the synthesis of steroidal compounds.

Abstract translation: 因此，苯并[e]茚衍生物和中间体已经通过从六氢二茚衍生物开始的各种方法制备。 苯并[e]茚末端产物属于已知类型的化合物，并且可用作合成甾族化合物的中间体。

公开(公告)号：US3920703A

公开(公告)日：1975-11-18

申请号：US50812774

申请日：1974-09-23

Applicant: HOFFMANN LA ROCHE

Inventor： ALIG LEO ,  FURST ANDOR ,  KELLER PETER ,  MULLER MARCEL ,  KERB ULRICH ,  WIECHERT RUDOLF

IPC: A61K31/56 ,  A61K31/585 ,  C07J63/00 ,  C07D307/94

CPC classification number: A61K31/56 ,  C07J63/008

Abstract: A novel class of D-homosteroid lactones is disclosed. The compounds are useful in controlling the mineral balance of the body and thus in the treatment of oedemas.