公开(公告)号：US20230002367A1

公开(公告)日：2023-01-05

申请号：US17771127

申请日：2020-10-26

Applicant: Hoffmann-La Roche Inc. ,  C4 THERAPEUTICS, INC.

Inventor： Delphine GAUFRETEAU ,  Roman HUTTER ,  Eleonora JOVCHEVA ,  Bernd KUHN ,  Thomas LUEBBERS ,  Rainer E. MARTIN ,  Laetitia Janine MARTIN ,  Barbara Johanna MUELLER ,  Roger NORCROSS ,  Fabienne RICKLIN ,  Philipp SCHMID ,  Jean-Yves WACH ,  Juergen WICHMANN ,  Martin DUPLESSIS ,  Kiel LAZARSKI ,  Yanke LIANG

IPC: C07D417/14 ,  C07D471/08 ,  C07D471/10 ,  C07D498/10 ,  C07D487/08

Abstract: The invention provides a bifunctional compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein said Targeting Ligand, Linker and Degron are as described herein.

公开(公告)号：US20150344429A1

公开(公告)日：2015-12-03

申请号：US14648412

申请日：2013-12-04

Applicant: HOFFMANN-LA ROCHE INC.

Inventor： Uwe GRETHER ,  Atsushi KIMBARA ,  Matthias NETTEKOVEN ,  Fabienne RICKLIN ,  Stephan ROEVER ,  Mark ROGERS-EVANS ,  Didier ROMBACH ,  Tanja SCHULZ-GASCH ,  Matthias WESTPHAL

IPC: C07D213/81 ,  C07D413/14 ,  C07D491/107 ,  C07D417/14 ,  C07D401/04 ,  C07D405/12 ,  C07D417/12

CPC classification number: C07D213/81 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D405/04 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D491/10 ,  C07D491/107

Abstract: The invention relates to a compound of formula (I) wherein R1 to R4 are defined as in the description and in the claims. The compound of formula (I) is a CB2 agonist and can be used as an active ingredient in a medicament.

Abstract translation: 本发明涉及式（I）化合物，其中R 1至R 4如说明书和权利要求中所定义。 式（I）化合物是CB 2激动剂，可用作药物中的活性成分。