公开(公告)号：US20160016968A1

公开(公告)日：2016-01-21

申请号：US14868305

申请日：2015-09-28

Applicant: Hoffmann-La Roche Inc.

Inventor： Olivier GAVELLE ,  Uwe GRETHER ,  Atsushi KIMBARA ,  Nettekoven MATTHIAS ,  Roever STEPHAN ,  Mark ROGERS-EVANS ,  Didier ROMBACH ,  Tanja SCHULZ-GASCH

IPC: C07D491/107 ,  C07D401/04 ,  C07D401/14 ,  C07D413/04 ,  C07D413/14

CPC classification number: C07D491/107 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D413/04 ,  C07D413/14

Abstract: The invention relates to a compound of formula (I) wherein A and R1 to R4 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.

公开(公告)号：US20210387999A1

公开(公告)日：2021-12-16

申请号：US17325934

申请日：2021-05-20

Applicant: Hoffmann-La Roche Inc.

Inventor： Bernd KUHN ,  Uwe GRETHER ,  Benoit HORNSPERGER ,  Hans RICHTER ,  Carsten KROLL ,  Katrin GROEBKE ZBINDEN ,  Fionn O'HARA ,  Didier ROMBACH ,  Marius Daniel Rinaldo LUTZ

IPC: C07D498/04 ,  C07D519/00

Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein A, B, L, X, R1, R2, R3 and R4 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

公开(公告)号：US20180290966A1

公开(公告)日：2018-10-11

申请号：US16003385

申请日：2018-06-08

Applicant: Hoffmann-La Roche Inc.

Inventor： Olivier GAVELLE ,  Uwe GRETHER ,  Matthias NETTEKOVEN ,  Stephan ROEVER ,  Mark ROGERS-EVANS ,  Didier ROMBACH

IPC: C07C235/52 ,  C07C231/02 ,  C07D271/06 ,  C07D277/28 ,  C07D205/04 ,  C07D413/12 ,  C07D305/08 ,  C07D331/04 ,  C07D207/16 ,  C07D413/10 ,  C07D213/61 ,  C07D403/10 ,  C07D231/12 ,  C07D401/10 ,  C07D207/10 ,  C07D413/06

Abstract: The invention relates to a compound of formula (I) wherein R1 to R3 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.

公开(公告)号：US20240383904A1

公开(公告)日：2024-11-21

申请号：US18632636

申请日：2024-04-11

Applicant: Hoffmann-La Roche Inc.

Inventor： Machoud AMOUSSA ,  Joerg BENZ ,  Julie Elisabeth Francoise BLAISING ,  Maude GIROUD ,  Uwe GRETHER ,  Carsten KROLL ,  Bernd KUHN ,  Rainer E. MARTIN ,  Fionn Susannah O’HARA ,  Bernd PUELLMANN ,  Martin RITTER ,  Didier ROMBACH ,  Philipp Claudio SCHMID ,  Matthias Beat WITTWER

IPC: C07D487/04 ,  A61K9/20 ,  A61K9/48 ,  A61K31/407 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/4188 ,  A61K31/4192 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/424 ,  A61K31/427 ,  A61K31/433 ,  A61K31/437 ,  A61K31/438 ,  A61K31/4439 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61K31/537 ,  A61K31/5386 ,  A61K31/675 ,  C07D471/10 ,  C07D498/10 ,  C07D519/00 ,  C07F9/6561

Abstract: The invention provides new MAGL inhibitors having the general formula (I) wherein the variables are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

公开(公告)号：US20240199587A1

公开(公告)日：2024-06-20

申请号：US18490967

申请日：2023-10-20

Applicant: Hoffmann-La Roche Inc.

Inventor： Machoud AMOUSSA ,  Joerg BENZ ,  Niels Kevin BRIAN ,  Kallie FRISTON ,  Maude GIROUD ,  Uwe GRETHER ,  Katrin GROEBKE ZBINDEN ,  Benoit HORNSPERGER ,  Carsten KROLL ,  Bernd KUHN ,  Camiel John LEAKE ,  Rainer E. MARTIN ,  David Friedrich Erhard NIPPA ,  Fionn Susannah O’HARA ,  Bernd PUELLMANN ,  Hans RICHTER ,  Martin RITTER ,  Didier ROMBACH ,  Philipp Claudio SCHMID ,  Shounan ZHANG

IPC: C07D403/14 ,  A61K31/4178 ,  A61K31/4196 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/438 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  A61K31/5377 ,  C07D401/14 ,  C07D407/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/10 ,  C07D487/10 ,  C07D491/052

CPC classification number: C07D403/14 ,  A61K31/4178 ,  A61K31/4196 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/438 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  A61K31/5377 ,  C07D401/14 ,  C07D407/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/10 ,  C07D487/10 ,  C07D491/052

Abstract: The invention provides new heterocyclic compounds having the general formula (I)




wherein A, B, X, and R1 to R7 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

公开(公告)号：US20150344429A1

公开(公告)日：2015-12-03

申请号：US14648412

申请日：2013-12-04

Applicant: HOFFMANN-LA ROCHE INC.

Inventor： Uwe GRETHER ,  Atsushi KIMBARA ,  Matthias NETTEKOVEN ,  Fabienne RICKLIN ,  Stephan ROEVER ,  Mark ROGERS-EVANS ,  Didier ROMBACH ,  Tanja SCHULZ-GASCH ,  Matthias WESTPHAL

IPC: C07D213/81 ,  C07D413/14 ,  C07D491/107 ,  C07D417/14 ,  C07D401/04 ,  C07D405/12 ,  C07D417/12

CPC classification number: C07D213/81 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D405/04 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D491/10 ,  C07D491/107

Abstract: The invention relates to a compound of formula (I) wherein R1 to R4 are defined as in the description and in the claims. The compound of formula (I) is a CB2 agonist and can be used as an active ingredient in a medicament.

Abstract translation: 本发明涉及式（I）化合物，其中R 1至R 4如说明书和权利要求中所定义。 式（I）化合物是CB 2激动剂，可用作药物中的活性成分。

公开(公告)号：US20250099448A1

公开(公告)日：2025-03-27

申请号：US18832840

申请日：2023-01-25

Applicant: Hoffmann-La Roche Inc.

Inventor： Machoud AMOUSSA ,  Joerg BENZ ,  Julie Elisabeth Francoise BLAISING ,  Jason Jacques DENIZOT ,  Kallie FRISTON ,  Rudolf Liun Zaccaria GANZONI ,  Maude GIROUD ,  Uwe GRETHER ,  Benoit HORNSPERGER ,  Isabelle KAUFMANN ,  Bernd KUHN ,  Camiel John LEAKE ,  Jacopo MARGARINI ,  Rainer Eugen MARTIN ,  Fionn Susannah O'HARA ,  Bernd PUELLMANN ,  Martin RITTER ,  Didier ROMBACH ,  Valerie RUNTZ-SCHMITT ,  Philipp Claudio SCHMID ,  Matthias Beat WITTWER

IPC: A61K31/4439 ,  A61K31/4196 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61K31/675 ,  C07D401/14 ,  C07D403/14 ,  C07D487/10

Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein A and R1 to R4 are as described heroin, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

公开(公告)号：US20240150373A1

公开(公告)日：2024-05-09

申请号：US18475065

申请日：2023-09-26

Applicant: Hoffmann-La Roche Inc.

Inventor： Charles BELL ,  Joerg BENZ ,  Luca GOBBI ,  Uwe GRETHER ,  Katrin GROEBKE ZBINDEN ,  Benoit HORNSPERGER ,  Buelent KOCER ,  Carsten KROLL ,  Bernd KUHN ,  Marius Daniel Rinaldo LUTZ ,  Fionn O'HARA ,  Hans RICHTER ,  Martin RITTER ,  Didier ROMBACH ,  Martin KURATLI

IPC: C07D498/04 ,  C07D519/00

CPC classification number: C07D498/04 ,  C07D519/00

Abstract: The invention provides new heterocyclic compounds having the general formula (I)




wherein A, L, X, m, n, R1 and R2 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

公开(公告)号：US20230050901A1

公开(公告)日：2023-02-16

申请号：US17749496

申请日：2022-05-20

Applicant: Hoffmann-La Roche Inc.

Inventor： Charles BELL ,  Joerg BENZ ,  Luca GOBBI ,  Uwe GRETHER ,  Katrin GROEBKE ZBINDEN ,  Benoit HORNSPERGER ,  Buelent KOCER ,  Carsten KROLL ,  Bernd KUHN ,  Marius Daniel Rinaldo LUTZ ,  Fionn O'HARA ,  Hans RICHTER ,  Martin RITTER ,  Didier ROMBACH ,  Martin KURATLI

IPC: C07D498/04 ,  C07D519/00

Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein A, L, X, m, n, R1 and R2 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

公开(公告)号：US20220135591A1

公开(公告)日：2022-05-05

申请号：US17497633

申请日：2021-10-08

Applicant: Hoffmann-La Roche Inc.

Inventor： Joerg BENZ ,  Guillaume DECORET ,  Uwe GRETHER ,  Katrin GROEBKE ZBINDEN ,  Benoit HORNSPERGER ,  Bernd KUHN ,  Hans RICHTER ,  Didier ROMBACH ,  Fionn O'HARA ,  Carsten KROLL

IPC: C07D498/04 ,  C07D519/00

Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein R1 to R7, A, L1, and RA1 to RA3 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.