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1.发明申请公开(公告)号：US20140017232A1
公开(公告)日：2014-01-16
申请号：US13802394
申请日：2013-03-13
发明人： Herbert Andres , Sanne Lysbet De Haas , Rebecca Elliott , Johann Karl , Yu-Ju Gloria Meng , Gregory D. Plowman , Stefan Scherer , Norbert Wild
IPC分类号： G01N33/74 , A61K45/06 , A61K39/395
CPC分类号： C07K16/22 , A61K31/337 , A61K31/513 , A61K31/517 , A61K31/70 , A61K31/7068 , A61K33/00 , A61K33/24 , A61K38/43 , A61K39/3955 , A61K39/39558 , A61K45/06 , G01N33/57434 , G01N33/57492 , G01N33/6893 , G01N33/74 , G01N2333/475 , G01N2800/52
摘要： The invention provides methods for identifying patient who may benefit from treatment with an anti-cancer therapy comprising a VEGF antagonist. The invention also provides methods for monitoring a patients' response to the anti-cancer therapy. The invention also provides kits and articles of manufacture for use in the methods.
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2.发明申请公开(公告)号：US20140056874A1
公开(公告)日：2014-02-27
申请号：US13802282
申请日：2013-03-13
发明人： Herbert Andres , Sanne Lysbet De Haas , Rebecca Elliott , Johann Karl , Yu-Ju Gloria Meng , Gregory D. Plowman , Stefan Scherer , Norbert Wild
IPC分类号： G01N33/68 , A61K45/06 , A61K39/395
CPC分类号： C07K16/22 , A61K31/337 , A61K31/513 , A61K31/517 , A61K31/70 , A61K31/7068 , A61K33/00 , A61K33/24 , A61K38/43 , A61K39/3955 , A61K39/39558 , A61K45/06 , G01N33/57434 , G01N33/57492 , G01N33/6893 , G01N33/74 , G01N2333/475 , G01N2800/52
摘要： The invention provides methods for identifying patient who may benefit from treatment with an anti-cancer therapy comprising a VEGF antagonist. The invention also provides methods for monitoring a patients' response to the anti-cancer therapy. The invention also provides kits and articles of manufacture for use in the methods.
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3.发明申请公开(公告)号：US20140017231A1
公开(公告)日：2014-01-16
申请号：US13802356
申请日：2013-03-13
发明人： Herbert Andres , Sanne Lysbet De Haas , Rebecca Elliott , Johann Karl , Yu-Ju Gloria Meng , Gregory D. Plowman , Stefan Scherer , Norbert Wild
IPC分类号： G01N33/74 , A61K45/06 , A61K39/395
CPC分类号： C07K16/22 , A61K31/337 , A61K31/513 , A61K31/517 , A61K31/70 , A61K31/7068 , A61K33/00 , A61K33/24 , A61K38/43 , A61K39/3955 , A61K39/39558 , A61K45/06 , G01N33/57434 , G01N33/57492 , G01N33/6893 , G01N33/74 , G01N2333/475 , G01N2800/52
摘要： The invention provides methods for identifying patient who may benefit from treatment with an anti-cancer therapy comprising a VEGF antagonist. The invention also provides methods for monitoring a patients' response to the anti-cancer therapy. The invention also provides kits and articles of manufacture for use in the methods.
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4.发明申请公开(公告)号：US20130336960A1
公开(公告)日：2013-12-19
申请号：US13744131
申请日：2013-01-17
发明人： Herbert Andres , Sanne Lysbet De Haas , Rebecca Elliott , Johann Karl , Yu-Ju Gloria Meng , Gregory D. Plowman , Stefan Scherer , Norbert Wild
IPC分类号： G01N33/68 , A61K45/06 , A61K39/395
CPC分类号： C07K16/22 , A61K31/337 , A61K31/513 , A61K31/517 , A61K31/70 , A61K31/7068 , A61K33/00 , A61K33/24 , A61K38/43 , A61K39/3955 , A61K39/39558 , A61K45/06 , G01N33/57434 , G01N33/57492 , G01N33/6893 , G01N33/74 , G01N2333/475 , G01N2800/52
摘要： The invention provides methods for identifying patient who may benefit from treatment with an anti-cancer therapy comprising a VEGF antagonist. The invention also provides methods for monitoring a patients' response to the anti-cancer therapy. The invention also provides kits and articles of manufacture for use in the methods.
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5.发明申请METHOD TO IDENTIFY A PATIENT WITH AN INCREASED LIKELIHOOD OF RESPONDING TO AN ANTI-CANCER THERAPY 审中-公开识别患有抗癌药治疗的增加症状的患者的方法公开(公告)号：US20140193397A1
公开(公告)日：2014-07-10
申请号：US13802333
申请日：2013-03-13
发明人： Herbert Andres , Sanne Lysbet De Haas , Rebecca Elliott , Johann Karl , Yu-Ju Gloria Meng , Gregory D. Plowman , Stefan Scherer , Norbert Wild
IPC分类号： G01N33/74 , A61K31/337 , A61K31/517 , A61K33/24 , A61K31/7068 , C07K16/22 , A61K39/395 , A61K31/513
CPC分类号： C07K16/22 , A61K31/337 , A61K31/513 , A61K31/517 , A61K31/70 , A61K31/7068 , A61K33/00 , A61K33/24 , A61K38/43 , A61K39/3955 , A61K39/39558 , A61K45/06 , G01N33/57434 , G01N33/57492 , G01N33/6893 , G01N33/74 , G01N2333/475 , G01N2800/52
摘要： The invention provides methods for identifying patient who may benefit from treatment with an anti-cancer therapy comprising a VEGF antagonist. The invention also provides methods for monitoring a patients' response to the anti-cancer therapy. The invention also provides kits and articles of manufacture for use in the methods.
摘要翻译： 本发明提供了用于鉴定可能受益于包含VEGF拮抗剂的抗癌疗法治疗的患者的方法。 本发明还提供了用于监测患者对抗癌疗法的反应的方法。 本发明还提供用于该方法的试剂盒和制品。
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6.发明申请公开(公告)号：US20140056875A1
公开(公告)日：2014-02-27
申请号：US13802303
申请日：2013-03-13
发明人： Herbert Andres , Sanne Lysbet De Haas , Rebecca Elliott , Johann Karl , Yu-Ju Gloria Meng , Gregory D. Plowman , Stefan Scherer , Norbert Wild
IPC分类号： G01N33/574 , A61K45/06 , A61K39/395
CPC分类号： C07K16/22 , A61K31/337 , A61K31/513 , A61K31/517 , A61K31/70 , A61K31/7068 , A61K33/00 , A61K33/24 , A61K38/43 , A61K39/3955 , A61K39/39558 , A61K45/06 , G01N33/57434 , G01N33/57492 , G01N33/6893 , G01N33/74 , G01N2333/475 , G01N2800/52
摘要： The invention provides methods for identifying patient who may benefit from treatment with an anti-cancer therapy comprising a VEGF antagonist. The invention also provides methods for monitoring a patients' response to the anti-cancer therapy. The invention also provides kits and articles of manufacture for use in the methods.
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7.发明申请公开(公告)号：US20140023639A1
公开(公告)日：2014-01-23
申请号：US13802379
申请日：2013-03-13
发明人： Herbert Andres , Sanne Lysbet De Haas , Rebecca Elliott , Johann Karl , Yu-Ju Gloria Meng , Gregory D. Plowman , Stefan Scherer , Norbert Wild
IPC分类号： G01N33/74 , A61K39/395
CPC分类号： C07K16/22 , A61K31/337 , A61K31/513 , A61K31/517 , A61K31/70 , A61K31/7068 , A61K33/00 , A61K33/24 , A61K38/43 , A61K39/3955 , A61K39/39558 , A61K45/06 , G01N33/57434 , G01N33/57492 , G01N33/6893 , G01N33/74 , G01N2333/475 , G01N2800/52
摘要： The invention provides methods for identifying patient who may benefit from treatment with an anti-cancer therapy comprising a VEGF antagonist. The invention also provides methods for monitoring a patients' response to the anti-cancer therapy. The invention also provides kits and articles of manufacture for use in the methods.
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8.发明申请公开(公告)号：US20130344059A1
公开(公告)日：2013-12-26
申请号：US13744140
申请日：2013-01-17
发明人： Herbert Andres , Sanne Lysbet De Haas , Rebecca Elliott , Johann Karl , Yu-Ju Gloria Meng , Gregory D. Plowman , Stefan Scherer , Norbert Wild
IPC分类号： G01N33/68 , A61K45/06 , A61K39/395
CPC分类号： C07K16/22 , A61K31/337 , A61K31/513 , A61K31/517 , A61K31/70 , A61K31/7068 , A61K33/00 , A61K33/24 , A61K38/43 , A61K39/3955 , A61K39/39558 , A61K45/06 , G01N33/57434 , G01N33/57492 , G01N33/6893 , G01N33/74 , G01N2333/475 , G01N2800/52
摘要： The invention provides methods for identifying patient who may benefit from treatment with an anti-cancer therapy comprising a VEGF antagonist. The invention also provides methods for monitoring a patients' response to the anti-cancer therapy. The invention also provides kits and articles of manufacture for use in the methods.
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9.发明申请Method to identify a patient with an increased likelihood of responding to an anti-cancer therapy 审中-公开识别患有抗癌治疗反应可能性增加的患者的方法公开(公告)号：US20130336959A1
公开(公告)日：2013-12-19
申请号：US13744014
申请日：2013-01-17
发明人： Herbert Andres , Sanne Lysbet De Haas , Rebecca Elliott , Johann Karl , Yu-Ju Gloria Meng , Gregory D. Plowman , Stefan Scherer , Norbert Wild
IPC分类号： G01N33/68 , A61K45/06 , A61K39/395
CPC分类号： C07K16/22 , A61K31/337 , A61K31/513 , A61K31/517 , A61K31/70 , A61K31/7068 , A61K33/00 , A61K33/24 , A61K38/43 , A61K39/3955 , A61K39/39558 , A61K45/06 , G01N33/57434 , G01N33/57492 , G01N33/6893 , G01N33/74 , G01N2333/475 , G01N2800/52
摘要： The invention provides methods for identifying patient who may benefit from treatment with an anti-cancer therapy comprising a VEGF antagonist. The invention also provides methods for monitoring a patients' response to the anti-cancer therapy. The invention also provides kits and articles of manufacture for use in the methods.
摘要翻译： 本发明提供了用于鉴定可能受益于包含VEGF拮抗剂的抗癌疗法治疗的患者的方法。 本发明还提供了用于监测患者对抗癌疗法的反应的方法。 本发明还提供用于该方法的试剂盒和制品。
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公开(公告)号：US20170066822A1
公开(公告)日：2017-03-09
申请号：US15354454
申请日：2016-11-17
IPC分类号： C07K16/22 , A61K45/06 , C12Q1/68 , A61K39/395
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158
摘要： The invention is concerned with a method of determining whether a patient is more suitably treated by a therapy with an angiogenesis inhibitor, such as bevacizumab, by determining the genotype of VEGFR-1 gene. The invention further relates to a pharmaceutical composition comprising an angiogenesis inhibitor, such as bevacizumab, for the treatment of a patient suffering from cancer based on the genotype of VEGFR-1 gene. The invention further relates to a method for improving the treatment effect of chemotherapy of a patient suffering from cancer by adding an angiogenesis inhibitor, such as bevacizumab, based on the genotype of VEGFR-1 gene.
摘要翻译： 本发明涉及通过确定VEGFR-1基因的基因型来确定患者是否通过用血管生成抑制剂如贝伐珠单抗的治疗更适当地治疗的方法。 本发明还涉及包含血管生成抑制剂如贝伐珠单抗的基于VEGFR-1基因的基因型治疗患有癌症的患者的药物组合物。 本发明还涉及基于VEGFR-1基因的基因型，通过添加血管发生抑制剂如贝伐珠单抗来改善患有癌症的患者的化疗的治疗效果的方法。
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