公开(公告)号：US20190101482A1

公开(公告)日：2019-04-04

申请号：US16086922

申请日：2017-03-22

Applicant: COMMISSARIAT Á L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES AL TERNATIVES ,  HORIBA ABX SAS ,  IPRASENSE SAS

Inventor： Cedric ALLIER ,  Anais ALI CHERIF ,  Pierre BLANDIN ,  Geoffrey ESTEBAN ,  Lionel HERVE ,  Damien ISEBE

IPC: G01N15/02 ,  G01N15/14 ,  G03H1/08

Abstract: A method for holographic characterization of a particle contained in a sample, based on an image, or hologram, of the sample obtained by an image sensor when the sample is illuminated by a light source. The hologram is the subject of a holographic reconstruction, to obtain a reference complex image, representative of the light wave transmitted by the sample in a reconstruction plane. A holographic propagation operator is applied to the reference complex image, to obtain a plurality of secondary complex images, from which a profile is determined describing the change in an optical feature of the light wave transmuted by the sample along the axis of propagation of the light wave.

公开(公告)号：US20200326269A1

公开(公告)日：2020-10-15

申请号：US16760777

申请日：2018-10-30

Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES ,  HORIBA ABX SAS

Inventor： Pierre BLANDIN ,  Anais ALI-CHERIF ,  Aurelien DAYNES ,  Estelle GREMION ,  Damien ISEBE

IPC: G01N15/02 ,  G01N15/14 ,  G03H1/08 ,  G03H1/00 ,  G06T7/62 ,  G06T7/11

Abstract: The invention is a method for estimating a representative volume of particles of interest (10 i) immersed in a sample, the sample extending in at least one plane, referred to as the sample plane (P 10), the sample comprising a sphering agent, capable of modifying the shape of the particles, the method comprising the following steps: a) illuminating the sample by means of a light source (11), the light source emitting an incident light wave (12) propagating towards the sample (10) along a propagation axis (Z); b) acquiring, by means of an image sensor (16), an image (I 0) of the sample (10), formed in a detection plane (P 0), the sample being arranged between the light source (11) and the image sensor (16), each image being representative of a light wave (14) referred to as an exposure light wave, to which the image sensor (16) is exposed under the effect of illumination; c) using the image of the sample (I 0), acquired during step b), and a holographic propagation operator, to calculate a complex expression (A (x, y, z)) of the exposure light wave (14) in different positions relative to the detection plane; the method comprising a step of estimating the representative volume (AA) of the particles of interest (10 i) depending on the complex expressions calculated during step c).

公开(公告)号：US20160151776A1

公开(公告)日：2016-06-02

申请号：US14905779

申请日：2014-07-17

Applicant: HORIBA ABX SAS

Inventor： Didier CREMIEN ,  Damien ISEBE

IPC: B01L3/02

Abstract: The present application relates to: (i) a sampler device for taking a sample of biological fluid, which comprises a capillary component, and a base rigidly connected to said capillary component and provided with a first connector capable of being reversibly attached in a leaktight manner to a second connector of a dispensing device; (ii) a dispensing device which also comprises means for transferring diluting fluid which open into said second connector. The application also relates to a biological analysis apparatus implementing the sampler and dispensing devices and to a method for sampling and dispensing a biological fluid.

Abstract translation: 本申请涉及：（i）用于取样生物流体样本的取样器装置，其包括毛细管部件，以及与所述毛细管部件刚性连接的基部，并且具有能够以密封方式可逆地连接的第一连接器 到分配装置的第二连接器; （ii）分配装置，其还包括用于传送打开到所述第二连接器中的稀释流体的装置。 该应用还涉及实施采样器和分配装置的生物分析装置以及用于取样和分配生物流体的方法。

公开(公告)号：US20230066255A1

公开(公告)日：2023-03-02

申请号：US17793208

申请日：2021-01-15

Applicant: HORIBA ABX SAS ,  UNIVERSITE DE MONTPELLIER ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

Inventor： Pierre TARACONAT ,  Damien ISEBE ,  Simon MENDEZ ,  Franck NICOUD

IPC: G01N15/12 ,  G01N33/487

Abstract: A medical analysis device with cellular impedance signal processing comprises a memory (4) arranged to receive pulse data sets, each pulse data set comprising impedance value data that are associated each time with a time marker, these data together representing a curve of cellular impedance values that are measured as a cell passes through a polarised opening. This device further comprises a classifier (6) comprising a convolutional neural network receiving the pulse data sets as input and is provided with at least one convolutional layer, which convolutional layer has a depth greater than or equal to 3, and at least two fully connected layers, in addition to an output layer rendering a cell classification from which a pulse data set is derived.

公开(公告)号：US20220196538A1

公开(公告)日：2022-06-23

申请号：US17606101

申请日：2020-04-24

Applicant: HORIBA ABX SAS ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S) ,  UNIVERSITE DE MONTPELLIER

Inventor： Pierre TARACONAT ,  Damien ISEBE ,  Simon MENDEZ ,  Franck NlCOUD

IPC: G01N15/10 ,  G01N15/12 ,  G01N15/02

Abstract: A device for medical analyses with cellular impedance signal processing comprises a memory (4) arranged to receive pulse data sets, each pulse data set comprising impedance value data that are associated each time with a time marker, these data together representing a curve of cellular impedance values that are measured as a cell passes through a polarized opening, a computer (6) arranged to process a pulse data set by determining a rotation value indicating whether the cell from which this pulse data set has been taken has undergone a rotation during its passage through the polarized opening, and a classifier (8) arranged to retrieve from the computer (6) a given pulse data set, and to use the resulting rotation value to classify the given pulse data set in a rotation pulse data set group (10) or a rotationless pulse data set group (12).