公开(公告)号：US20160019337A1

公开(公告)日：2016-01-21

申请号：US14772038

申请日：2014-03-03

Applicant: HTG MOLECULAR DIAGNOSTICS, INC.

Inventor： Christopher Roberts ,  Hui Wang ,  Zhenquiang Lu ,  Krishna Maddula ,  Sam Rua ,  Kevin Knapp ,  Byron Lawson ,  Debrah Thompson ,  Michael Hrubiak ,  Tyler Breedlove ,  Vijay Modur

IPC: G06F19/20 ,  C12Q1/68

CPC classification number: G16B25/00 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N33/57423

Abstract: This disclosure concerns the identification of biomarkers that are characteristic of squamous or non squamous (e.g., adenocarcinoma, large cell carcinoma, carcinoid tumor, sarcomatoid carcinoma) subtypes of non small cell lung cancer (NSCLC), clinically useful NSCLC classifiers, kits and arrays for distinguishing squamous and nonsquamous NSCLC subtypes, bioinformatic methods for determining clinically useful classifiers, and methods of use of each of the foregoing.

Abstract translation: 本公开涉及鉴定非小细胞肺癌（NSCLC）的鳞状或非鳞状体（例如，腺癌，大细胞癌，类癌瘤，肉瘤样癌）亚型，临床上有用的NSCLC分类器，试剂盒和阵列的特征性生物标志物 区分鳞状和非鳞状NSCLC亚型，用于确定临床有用的分类器的生物信息学方法，以及上述每一种的使用方法。

公开(公告)号：US09758829B2

公开(公告)日：2017-09-12

申请号：US14405739

申请日：2013-06-24

Applicant: HTG Molecular Diagnostics, Inc. ,  John Wayne Cancer Institute

Inventor： Hui Wang ,  Christopher Roberts ,  Krishna Maddula ,  Zhenquiang Lu ,  Tom Vasicek ,  B J Kerns ,  Bruce E. Seligmann ,  Dave S. B. Hoon

IPC: C12Q1/68

CPC classification number: C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/158 ,  C12Q2600/16 ,  C12Q2600/166 ,  C12Q2600/178

Abstract: Disclosed are methods for determining whether a melanocyte-containing sample (such as a nevus or other pigmented lesion) is benign or a primary melanoma. These methods can include detecting (at the molecular level, e.g., mRNA, miRNA, or protein) the expression of at least two disclosed genes in a biological sample obtained from a subject. Also provided are arrays and kits that can be used with the methods.

公开(公告)号：US20150176072A1

公开(公告)日：2015-06-25

申请号：US14405739

申请日：2013-06-24

Applicant: HTG Molecular Diagnostics, Inc. ,  John Wayne Cancer Institute

Inventor： Hui Wang ,  Christopher Roberts ,  Krishna Maddula ,  Zhenquiang Lu ,  Justin Brown ,  Tom Vasicek ,  BJ Kerns ,  Bruce E. Seligmann ,  Dave S.B. Hoon

IPC: C12Q1/68

CPC classification number: C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/158 ,  C12Q2600/16 ,  C12Q2600/166 ,  C12Q2600/178

Abstract: Disclosed are methods for determining whether a melanocyte-containing sample (such as a nevus or other pigmented lesion) is benign or a primary melanoma. These methods can include detecting (at the molecular level, e.g., mRNA, miRNA, or protein) the expression of at least two disclosed genes in a biological sample obtained from a subject. Also provided are arrays and kits that can be used with the methods.

Abstract translation: 公开了用于确定含黑素细胞的样品（例如痣或其它色素性病变）是否为良性或原发性黑素瘤的方法。 这些方法可以包括在从受试者获得的生物样品中检测（在分子水平，例如mRNA，miRNA或蛋白质）至少两个公开的基因的表达。 还提供了可以与方法一起使用的数组和试剂盒。