公开(公告)号：US20210052523A1

公开(公告)日：2021-02-25

申请号：US16977722

申请日：2019-03-06

Applicant: Hadasit Medical Research Services and Development Ltd.

Inventor： Eithan GALUN ,  Hilla GILADI ,  Chofit CHAI ,  Nofar ROSENBERG ,  Dayana YAISH ,  Zohar SHMUELIAN

IPC: A61K31/167 ,  A61P35/00 ,  A61P35/04

Abstract: The present invention provides compositions having one or more agents capable of increasing expression of one or more endogenous tumor suppressive mi RNAs in one or more producing cells, such that the endogenous mi RNAs can affect one or more target cancer cells. Further provided are method and uses thereof for treating cancer.

公开(公告)号：US20210052603A1

公开(公告)日：2021-02-25

申请号：US17051332

申请日：2019-05-03

Applicant: Emory University ,  Hadasit Medical Research Services and Development Ltd.

Inventor： Raymond F. Schinazi ,  Bryan COX ,  Chofit CHAI ,  Hilla GILADI ,  Eithan GALUN ,  Franck AMBLARD

IPC: A61K31/5513 ,  A61K33/243 ,  A61K31/475 ,  A61K31/015 ,  A61K31/131 ,  A61K45/06 ,  C07D401/10 ,  C07D403/10 ,  C07D413/10 ,  C07D401/12

Abstract: Compounds, compositions and methods for modulating retinoic acid receptor-like orphan receptors (ROR) and associated diseases. Methods for treatment or prophylaxis of metabolic disorders, liver disorders or diseases, including NASH, immune disorders, central nervous system disorders, or cancer are disclosed.