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公开(公告)号：US20210052523A1
公开(公告)日：2021-02-25
申请号：US16977722
申请日：2019-03-06
Inventor： Eithan GALUN , Hilla GILADI , Chofit CHAI , Nofar ROSENBERG , Dayana YAISH , Zohar SHMUELIAN
IPC: A61K31/167 , A61P35/00 , A61P35/04
Abstract: The present invention provides compositions having one or more agents capable of increasing expression of one or more endogenous tumor suppressive mi RNAs in one or more producing cells, such that the endogenous mi RNAs can affect one or more target cancer cells. Further provided are method and uses thereof for treating cancer.
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2.发明申请MIR-122* AS AN ACTIVE MICRO-RNA, COMPOSITIONS COMPRISING THE SAME AND USES THEREOF 审中-公开MIR-122 *作为活性微RNA，包含其的组合物及其用途公开(公告)号：US20160333344A1
公开(公告)日：2016-11-17
申请号：US15109879
申请日：2015-01-06
Inventor： Hilla GILADI , Alina SIMERZIN , Yael HANTZ , Sagit ARBEL ALON , Eithan GALUN
IPC: C12N15/113 , A61K45/06 , A61K31/7088
CPC classification number: C12N15/113 , A61K31/7088 , A61K31/7105 , A61K31/713 , A61K45/06 , C12N2310/141 , C12N2320/30 , C12N2320/31 , A61K2300/00
Abstract: Provided is a miR-122* as a functional microRNA molecule, compositions including the same and uses thereof for treatment of various conditions, such as, cancer.
Abstract translation: 提供了作为功能性微小RNA分子的miR-122 *，包含其的组合物及其用于治疗各种病症如癌症的用途。
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公开(公告)号：US20210052603A1
公开(公告)日：2021-02-25
申请号：US17051332
申请日：2019-05-03
Inventor： Raymond F. Schinazi , Bryan COX , Chofit CHAI , Hilla GILADI , Eithan GALUN , Franck AMBLARD
IPC: A61K31/5513 , A61K33/243 , A61K31/475 , A61K31/015 , A61K31/131 , A61K45/06 , C07D401/10 , C07D403/10 , C07D413/10 , C07D401/12
Abstract: Compounds, compositions and methods for modulating retinoic acid receptor-like orphan receptors (ROR) and associated diseases. Methods for treatment or prophylaxis of metabolic disorders, liver disorders or diseases, including NASH, immune disorders, central nervous system disorders, or cancer are disclosed.
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