-
公开(公告)号：US20070010893A1
公开(公告)日：2007-01-11
申请号：US11518984
申请日：2006-09-12
申请人： Hai Wen , Janet Moradian-Oldak
发明人： Hai Wen , Janet Moradian-Oldak
CPC分类号： A61L27/12 , A61L27/06 , A61L27/227 , C30B7/005
摘要： The invention provides novel dental enamel inspired materials for biomedical and dental applications. The materials are apatite-like calcium phosphate complexes and may comprise apatite, octacalcium phosphate crystals, or mixtures thereof. In one embodiment, the materials (calcium phosphate coatings) are mixtures of crystals of apatite and its precursor, octacalcium phosphate, nucleated on a titanium surface. They are prepared using a chemical process leading to the formation of biological apatite which is similar to that found in natural bone and teeth. In one embodiment, the materials are prepared by placing a titanium substrate in a supersaturated calcifyng solution containing native or purified recombinant amelogenins. The presence of the amelogenins modulates apatite crystal growth to mimic in vivo apatite crystal formation. Applications for the materials include, without limitation, dental tissue (enamel, dentin, cementum) replacement, orthopeadic implants for bone repair, and coatings for improving the biocompatibility and bone regeneration capability of currently available implants or medical devices made of metallic, polymeric, ceramic or composite materials.
摘要翻译： 本发明提供用于生物医学和牙科应用的新颖的牙科搪瓷启发材料。 这些材料是磷灰石样磷酸钙复合物，并且可以包含磷灰石，磷酸二钙晶体或其混合物。 在一个实施方案中，材料（磷酸钙涂层）是磷灰石及其前体的晶体的混合物，磷酸二钙，在钛表面成核。 它们使用化学过程制备，导致形成生物磷灰石，其类似于在天然骨骼和牙齿中发现的生物磷灰石。 在一个实施方案中，通过将钛底物置于含有天然或纯化的重组朊蛋白酶的过饱和钙化溶液中来制备材料。 斑log素的存在调节磷灰石晶体生长以模拟体内磷灰石晶体形成。 材料的应用包括但不限于牙科组织（牙釉质，牙本质，牙骨质）替代物，用于骨修复的矫形植入物，以及用于改善目前可用的植入物或由金属，聚合物，陶瓷制成的医疗装置的生物相容性和骨再生能力的涂层 或复合材料。
-
公开(公告)号：US08545625B2
公开(公告)日：2013-10-01
申请号：US11518984
申请日：2006-09-12
申请人： Hai Bo Wen , Janet Moradian-Oldak
发明人： Hai Bo Wen , Janet Moradian-Oldak
CPC分类号： A61L27/12 , A61L27/06 , A61L27/227 , C30B7/005
摘要： The invention provides novel dental enamel inspired materials for biomedical and dental applications. The materials are apatite-like calcium phosphate complexes and may comprise apatite, octacalcium phosphate crystals, or mixtures thereof. In one embodiment, the materials (calcium phosphate coatings) are mixtures of crystals of apatite and its precursor, octacalcium phosphate, nucleated on a titanium surface. They are prepared using a chemical process leading to the formation of biological apatite which is similar to that found in natural bone and teeth. In one embodiment, the materials are prepared by placing a titanium substrate in a supersaturated calcifying solution containing native or purified recombinant amelogenins. The presence of the amelogenins modulates apatite crystal growth to mimic in vivo apatite crystal formation. Applications for the materials include, without limitation, dental tissue (enamel, dentin, cementum) replacement, orthopeadic implants for bone repair, and coatings for improving the biocompatibility and bone regeneration capability of currently available implants or medical devices made of metallic, polymeric, ceramic or composite materials.
摘要翻译： 本发明提供用于生物医学和牙科应用的新颖的牙科搪瓷启发材料。 这些材料是磷灰石样磷酸钙复合物，并且可以包含磷灰石，磷酸二钙晶体或其混合物。 在一个实施方案中，材料（磷酸钙涂层）是磷灰石及其前体的晶体的混合物，磷酸二钙，在钛表面成核。 它们使用化学过程制备，导致形成生物磷灰石，其类似于在天然骨骼和牙齿中发现的生物磷灰石。 在一个实施方案中，通过将钛底物置于含有天然或纯化的重组朊蛋白原的过饱和钙化溶液中来制备材料。 斑log素的存在调节磷灰石晶体生长以模拟体内磷灰石晶体形成。 材料的应用包括但不限于牙科组织（牙釉质，牙本质，牙骨质）替代物，用于骨修复的矫形植入物，以及用于改善目前可用的植入物或由金属，聚合物，陶瓷制成的医疗装置的生物相容性和骨再生能力的涂层 或复合材料。
-
公开(公告)号：US07132015B2
公开(公告)日：2006-11-07
申请号：US10371678
申请日：2003-02-20
申请人： Hai Bo Wen , Janet Moradian-Oldak
发明人： Hai Bo Wen , Janet Moradian-Oldak
IPC分类号： C30B7/00
CPC分类号： A61L27/12 , A61L27/06 , A61L27/227 , C30B7/005
摘要： The invention provides novel dental enamel inspired materials for biomedical and dental applications. The materials are apatite-like calcium phosphate complexes and may comprise apatite, octacalcium phosphate crystals, or mixtures thereof. In one embodiment, the materials (calcium phosphate coatings) are mixtures of crystals of apatite and its precursor, octacalcium phosphate, nucleated on a titanium surface. They are prepared using a chemical process leading to the formation of biological apatite which is similar to that found in natural bone and teeth. In one embodiment, the materials are prepared by placing a titanium substrate in a supersaturated calcifying solution containing native or purified recombinant amelogenins. The presence of the amelogenins modulates apatite crystal growth to mimic in vivo apatite crystal formation. Applications for the materials include, without limitation, dental tissue (enamel, dentin, cementum) replacement, orthopeadic implants for bone repair, and coatings for improving the biocompatibility and bone regeneration capability of currently available implants or medical devices made of metallic, polymeric, ceramic or composite materials.
-
-
搜索结果
3 条记录 (耗时 0.022 秒)
