公开(公告)号：US20140201275A1

公开(公告)日：2014-07-17

申请号：US13742943

申请日：2013-01-16

申请人： Haihua Huang ,  Yong Qian ,  Yaqing Zhang ,  Kejun Xia

发明人： Haihua Huang ,  Yong Qian ,  Yaqing Zhang ,  Kejun Xia

IPC分类号： H04L29/06

CPC分类号： H04L65/403 ,  H04L65/1083 ,  H04L67/14 ,  H04L67/36

摘要： An example method is provided and includes receiving conversation precondition information associated with a meeting session in a network environment, determining, after a beginning of the meeting session, conversation precondition status information of at least one collaboration criteria indicated by the conversation precondition information, and causing a meeting client program to provide a representation of the conversation precondition status information.

摘要翻译： 提供了一种示例性方法，并且包括在网络环境中接收与会议会话相关联的对话前提条件信息，在会议会话开始之后，确定由对话前提条件信息指示的至少一个协作标准的会话基准状态信息，并且引起 会议客户端程序，用于提供会话前提条件状态信息的表示。

公开(公告)号：US09072735B2

公开(公告)日：2015-07-07

申请号：US12900812

申请日：2010-10-08

申请人： Yong Qian

发明人： Yong Qian

IPC分类号： A61K38/48 ,  A61P35/00 ,  C12N9/50

CPC分类号： A61K38/48 ,  A61K38/482 ,  A61K2300/00

摘要： A proteinase therapy has been invented to eliminate solid tumors by destroying tumors' solid structure and killing cancer cells by cleaving vital extracellular matrix proteins C-terminally, N-terminally or both with cell membrane intact and limited adverse effects. The micro-scale intratumoral proteinase K therapy is tumor specific but not cancer type specific. Proteinase K therapy can be operated on multiple tumors on multiple occasions, if necessary. It may be employed to eliminate any solid tumor to prolong a cancer patient's life span.

摘要翻译： 已经发明了一种蛋白酶治疗方法，通过破坏肿瘤的固体结构，通过切除细胞外基质蛋白C末端，N末端或两者与细胞膜完整和有限的不良反应来破坏肿瘤细胞，来消除实体瘤。 微量肿瘤内蛋白酶K治疗是肿瘤特异性但不是癌症类型特异性。 如果需要，蛋白酶K治疗可以在多种肿瘤上进行操作。 可用于消除任何实体肿瘤以延长癌症患者的寿命。

公开(公告)号：US20050100622A1

公开(公告)日：2005-05-12

申请号：US10945609

申请日：2005-01-10

申请人： Muraleedharan Nair ,  David Dewitt ,  Haibo Wang ,  David Krempin ,  Dipak Mody ,  David Groh ,  Mary Murray ,  Marc Lemay ,  Yong Qian ,  Audra Davies ,  Robin Dykhouse

发明人： Muraleedharan Nair ,  David Dewitt ,  Haibo Wang ,  David Krempin ,  Dipak Mody ,  David Groh ,  Mary Murray ,  Marc Lemay ,  Yong Qian ,  Audra Davies ,  Robin Dykhouse

IPC分类号： A23L1/30 ,  A61K36/29 ,  A61K36/35 ,  A61K36/45 ,  A61K36/736 ,  A61K31/7048 ,  A61K31/353 ,  A61K35/78

CPC分类号： A61K36/736 ,  A23L33/105 ,  A23V2002/00 ,  A61K36/185 ,  A61K36/29 ,  A61K36/35 ,  A61K36/45 ,  A23V2250/2104 ,  A61K2300/00

摘要： The present invention describes food supplements that contain one or more fruit extracts useful for pain relief and anti-inflammation. The food supplements may be used to inhibit inflammation mediated by cyclooxygenase and more particularly by cyclooxygenase-2.

摘要翻译： 本发明描述了含有一种或多种可用于缓解疼痛和抗炎的水果提取物的食品添加剂。 食物补充剂可用于抑制由环加氧酶介导的炎症，更特别地通过环氧合酶-2。

公开(公告)号：US06429021B1

公开(公告)日：2002-08-06

申请号：US09044573

申请日：1998-03-19

申请人： Yong Qian ,  Richard E. A. Leitz ,  David W. Krempin

发明人： Yong Qian ,  Richard E. A. Leitz ,  David W. Krempin

IPC分类号： G01N3090

CPC分类号： G01N33/50 ,  G01N2030/062 ,  Y10T436/20 ,  Y10T436/255

摘要： The present invention provides an assay for detecting the presence of an array or a profile of antioxidant activity in any sources or products. In particular, the invention provides a method in which a sample is extracted with a polar, a non-polar and a semi-polar solvent to obtain three extracts; the extracts are chromatographed to get a chemical profile; and the profile is analyzed to determine the presence of antioxidants by directly reacting to a free-radical.

摘要翻译： 本发明提供了用于检测任何来源或产品中抗氧化活性的阵列或轮廓的存在的测定法。 特别地，本发明提供一种方法，其中用极性，非极性和半极性溶剂萃取样品以获得三种提取物; 萃取液进行色谱分离，得到化学分布; 并分析轮廓以通过直接与自由基反应来确定抗氧化剂的存在。

公开(公告)号：US20170258883A1

公开(公告)日：2017-09-14

申请号：US15599479

申请日：2017-05-19

申请人： Yong Qian

发明人： Yong Qian

IPC分类号： A61K39/00 ,  A61K45/06 ,  A61K39/39 ,  A61K38/17

CPC分类号： A61K39/0011 ,  A61K38/1709 ,  A61K45/06 ,  A61K2039/5152 ,  A61K2300/00

摘要： Disclosed is a method of making a proteinase-engineered cancer vaccine or cancer-cell-derived spheres for treating a cancer patient, especially for cancer patients at advanced/metastatic stage. The cancer vaccine comprises dead cancer-cell-derived spheres with unbroken plasma membrane wherein the extracellular proteins and extracellular portion of membrane proteins are cleaved by proteinase digestion. The cancer vaccine may be derived from cancer cell lines or patients' cancer cells or derivatives. Also disclosed is a method of treating a cancer patient by administrating an effective amount of the cancer vaccine or cancer-cell-derived spheres to the patient. The present invention further provides a method of treating multiple diseases in addition to cancers by the cancer-cell-derived spheres, and obtaining cancer-specific immune components from blood of individuals treated with the cancer-cell-derived spheres.

公开(公告)号：US09669082B2

公开(公告)日：2017-06-06

申请号：US14594166

申请日：2015-01-11

申请人： Yong Qian

发明人： Yong Qian

IPC分类号： A61K39/00

CPC分类号： A61K39/0011 ,  A61K2039/5152

摘要： The present invention provides a method of making a proteinase-engineered cancer vaccine for treating a cancer patient, especially for cancer patient at advanced/metastatic stage. The cancer vaccine comprises dead cancer cells with unbroken plasma membrane wherein the extracellular proteins and extracellular portion of membrane proteins are cleaved by proteinase digestion. The cancer vaccine may be derived from cancer cell lines or patients' cancer cells. The present invention provides a method of treating a cancer patient by administrating an effective amount of the cancer vaccine to the patient. In a clinical trial with 35 cancer patients, the cancer vaccine therapy brings cancer-free lives (no detectable tumor, micro tumor or cancer cells after treatments of customized cancer vaccines) back to 40% of these patients. The present invention further provides a method of obtaining cancer-specific immune components from blood of individuals treated with the cancer vaccine.

公开(公告)号：US20150132285A1

公开(公告)日：2015-05-14

申请号：US14594166

申请日：2015-01-11

申请人： Yong Qian

发明人： Yong Qian

IPC分类号： A61K39/00 ,  C07K16/18

CPC分类号： A61K39/0011 ,  A61K2039/5152

摘要： The present invention provides a method of making a proteinase-engineered cancer vaccine for treating a cancer patient, especially for cancer patient at advanced/metastatic stage. The cancer vaccine comprises dead cancer cells with unbroken plasma membrane wherein the extracellular proteins and extracellular portion of membrane proteins are cleaved by proteinase digestion. The cancer vaccine may be derived from cancer cell lines or patients' cancer cells. The present invention provides a method of treating a cancer patient by administrating an effective amount of the cancer vaccine to the patient. In a clinical trial with 35 cancer patients, the cancer vaccine therapy brings cancer-free lives (no detectable tumor, micro tumor or cancer cells after treatment) back to 40% of these patients. The cancer vaccine therapy for the first time brings the promise of cure to this deadly disease. The present invention further provides a method of obtaining cancer-specific immune components from blood of individuals treated with the cancer vaccine.

摘要翻译： 本发明提供了一种制备用于治疗癌症患者的蛋白酶工程化癌症疫苗的方法，特别是对于晚期/转移期的癌症患者。 癌症疫苗包括具有不间断质膜的死亡癌细胞，其中细胞外蛋白质和膜蛋白质的细胞外部分被蛋白酶消化切割。 癌症疫苗可以衍生自癌细胞系或患者的癌细胞。 本发明提供了通过向患者施用有效量的癌症疫苗来治疗癌症患者的方法。 在35名癌症患者的临床试验中，癌症疫苗治疗将无癌生命（治疗后无可检测的肿瘤，微型肿瘤或癌细胞）带回到这些患者的40％。 癌症疫苗治疗第一次带来了治愈这种致命疾病的希望。 本发明还提供从用癌症疫苗治疗的个体的血液中获得癌症特异性免疫成分的方法。

公开(公告)号：US08337914B2

公开(公告)日：2012-12-25

申请号：US10945609

申请日：2004-09-21

申请人： Muraleedharan G. Nair ,  David L. Dewitt ,  Haibo Wang ,  David W. Krempin ,  Dipak K. Mody ,  David G. Groh ,  Mary A. Murray ,  Marc Lemay ,  Yong Qian ,  Audra J. Davies ,  Robin Dykhouse

发明人： Muraleedharan G. Nair ,  David L. Dewitt ,  Haibo Wang ,  David W. Krempin ,  Dipak K. Mody ,  David G. Groh ,  Mary A. Murray ,  Marc Lemay ,  Yong Qian ,  Audra J. Davies ,  Robin Dykhouse

IPC分类号： A61K36/04 ,  A61K36/736 ,  A61K36/00

CPC分类号： A61K36/736 ,  A23L33/105 ,  A23V2002/00 ,  A61K36/185 ,  A61K36/29 ,  A61K36/35 ,  A61K36/45 ,  A23V2250/2104 ,  A61K2300/00

摘要： The present invention describes food supplements that contain one or more fruit extracts useful for pain relief and anti-inflammation. The food supplements may be used to inhibit inflammation mediated by cyclooxygenase and more particularly by cyclooxygenase-2.

摘要翻译： 本发明描述了含有一种或多种可用于缓解疼痛和抗炎的水果提取物的食品添加剂。 食物补充剂可用于抑制由环加氧酶介导的炎症，更特别地通过环氧合酶-2。

公开(公告)号：US06991811B1

公开(公告)日：2006-01-31

申请号：US09575307

申请日：2000-05-19

申请人： Ernesto A. Brovelli ,  Yong Qian ,  Puri G. David ,  Kari L. Truax ,  Yingqin Li

发明人： Ernesto A. Brovelli ,  Yong Qian ,  Puri G. David ,  Kari L. Truax ,  Yingqin Li

IPC分类号： A61K35/78

CPC分类号： A61K36/28

摘要： The present invention relates to the use of Echinacea as a cancer chemopreventive agent to block the formation of and to detoxify cancer-causing agents, or carcinogens. More particularly, the present invention relates to the induction of phase II enzymes by Echinacea, and specifically by lipid-soluble fractions isolated from Echinacea. The present invention also contemplates a novel method of extracting the desired lipid-soluble fractions from Echinacea.

摘要翻译： 本发明涉及紫锥花作为癌症化学预防剂阻断致癌剂或致癌物的形成和解毒的用途。 更具体地说，本发明涉及通过紫锥花诱导II期酶，特别涉及从紫锥菊分离的脂溶性级分。 本发明还考虑了从紫锥菊中提取所需脂溶性级分的新方法。

公开(公告)号：US06869771B1

公开(公告)日：2005-03-22

申请号：US10223233

申请日：2002-08-19

申请人： Yong Qian

发明人： Yong Qian

IPC分类号： C12Q1/24

CPC分类号： C12Q1/24

摘要： A method for distributing an equal volume of attached confluent living cells in each well of a multi-well plate used in a bioassay, comprising the following steps:(a) growing attached living cells on a medium until the cells are confluent; (b) treating the attached confluent living cells with an enzyme solution, whereby the solution and the attached confluent living cells make a cell suspension; (c) filtering the cell suspension with a filter; (d) collecting a cell suspension filtrate containing uniformly distributed attached confluent living cells therein; and (e) distributing an equal volume of the cell suspension filtrate into wells of a plate whereby each well has an equal volume of cells for use in any bioassay.

摘要翻译： 一种用于在生物测定中使用的多孔板的每个孔中分配等体积的附着的汇合活细胞的方法，包括以下步骤：（a）在培养基上生长连接的活细胞直至细胞融合; （b）用酶溶液处理附着的汇合活细胞，由此溶液和附着的汇合活细胞形成细胞悬浮液; （c）用过滤器过滤细胞悬浮液; （d）收集其中含有均匀分布的附着的汇合活细胞的细胞悬浮液滤液; 和（e）将等体积的细胞悬浮液滤液分配到板的孔中，由此每个孔具有用于任何生物测定的等体积的细胞。