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公开(公告)号：US20070244156A1
公开(公告)日：2007-10-18
申请号：US11756008
申请日：2007-05-31
申请人： Hamed Aissaoui , Martine Clozel , Walter Fischli , Ralf Koberstein , Thierry Sifferlen , Thomas Weller
发明人： Hamed Aissaoui , Martine Clozel , Walter Fischli , Ralf Koberstein , Thierry Sifferlen , Thomas Weller
IPC分类号： A61K31/18 , A61K31/4184 , A61K31/44 , A61K31/473
CPC分类号： C07C311/21 , A61K31/18 , A61K31/4184 , A61K31/44 , A61K31/473 , C07C311/13 , C07C311/20 , C07C311/29 , C07C2601/02 , C07C2601/14 , C07D207/323 , C07D209/14 , C07D213/40 , C07D213/53 , C07D213/71 , C07D213/74 , C07D213/75 , C07D215/12 , C07D215/36 , C07D215/38 , C07D217/02 , C07D231/56 , C07D233/64 , C07D277/28 , C07D401/12 , C07D401/14 , C07D417/12
摘要： The invention relates to novel sulfonylamino-acetic acid derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of such compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as orexin receptor antagonists.
摘要翻译： 本发明涉及新型磺酰基氨基 - 乙酸衍生物及其在制备药物组合物中作为活性成分的用途。 本发明还涉及包括制备这些化合物的方法，包含一种或多种这些化合物的药物组合物，特别是其作为食欲素受体拮抗剂的用途的相关方面。
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公开(公告)号：US20070191424A1
公开(公告)日：2007-08-16
申请号：US10598449
申请日：2005-02-23
IPC分类号： A61K31/4709 , A61K31/47 , C07D401/02
CPC分类号： C07D217/18 , C07D401/06
摘要： The invention relates to novel 1,2,3,4-tetrahydroisoquinoline derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, phannaceutical compositions containing one or more of those compounds and methods of treatment comprising administration of said compounds to a mammal.
摘要翻译： 本发明涉及新型1,2,3,4-四氢异喹啉衍生物及其在制备药物组合物中作为活性成分的用途。 本发明还涉及包括制备化合物的方法，含有一种或多种这些化合物的药物组合物和包括向哺乳动物施用所述化合物的治疗方法的相关方面。
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3.发明授权Benzazepines and related heterocyclic derivatives which are useful as orexin receptor antagonists 失效苯并氮杂类和相关杂环衍生物，可用作食欲素受体拮抗剂公开(公告)号：US07192950B2
公开(公告)日：2007-03-20
申请号：US10450420
申请日：2001-12-19
申请人： Hamed Aissaoui , Martine Clozel , Thomas Weller , Ralf Koberstein , Thierry Sifferlen , Walter Fischli
发明人： Hamed Aissaoui , Martine Clozel , Thomas Weller , Ralf Koberstein , Thierry Sifferlen , Walter Fischli
IPC分类号： A61P3/04 , A61K31/55 , C07D223/16
CPC分类号： C07D223/16 , A61K31/55 , C07D243/14 , C07D267/14 , C07D281/10 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12
摘要： The invention relates to novel benzazepines and related heterocyclic derivatives (I) and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as orexin receptor antagonists.
摘要翻译： 本发明涉及新的苯并氮杂和相关杂环衍生物（I）及其作为药物组合物制备中的活性成分的用途。 本发明还涉及包括制备化合物的方法，含有一种或多种这些化合物的药物组合物，特别是其作为食欲素受体拮抗剂的用途的相关方面。
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公开(公告)号：US07279578B2
公开(公告)日：2007-10-09
申请号：US10529637
申请日：2003-10-06
申请人： Hamed Aissaoui , Martine Clozel , Walter Fischli , Ralf Koberstein , Thierry Sifferlen , Thomas Weller
发明人： Hamed Aissaoui , Martine Clozel , Walter Fischli , Ralf Koberstein , Thierry Sifferlen , Thomas Weller
IPC分类号： C07C311/13 , C07C311/20 , C07D213/76 , C07D213/75 , C07D215/38
CPC分类号： C07C311/21 , A61K31/18 , A61K31/4184 , A61K31/44 , A61K31/473 , C07C311/13 , C07C311/20 , C07C311/29 , C07C2601/02 , C07C2601/14 , C07D207/323 , C07D209/14 , C07D213/40 , C07D213/53 , C07D213/71 , C07D213/74 , C07D213/75 , C07D215/12 , C07D215/36 , C07D215/38 , C07D217/02 , C07D231/56 , C07D233/64 , C07D277/28 , C07D401/12 , C07D401/14 , C07D417/12
摘要： The invention relates to novel sulfonylamino-acetic acid derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of such compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as orexin receptor antagonists.
摘要翻译： 本发明涉及新型磺酰基氨基 - 乙酸衍生物及其在制备药物组合物中作为活性成分的用途。 本发明还涉及包括制备这种化合物的方法，含有一种或多种这些化合物的药物组合物，特别是其作为食欲素受体拮抗剂的用途的相关方面。
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公开(公告)号：US20060014783A1
公开(公告)日：2006-01-19
申请号：US10529637
申请日：2003-10-06
申请人： Hamed Aissaoui , Martine Clozel , Walter Fischli , Ralf Koberstein , Thierry Sifferlen , Thomas Weller
发明人： Hamed Aissaoui , Martine Clozel , Walter Fischli , Ralf Koberstein , Thierry Sifferlen , Thomas Weller
IPC分类号： A61K31/47 , A61K31/18 , C07C311/34
CPC分类号： C07C311/21 , A61K31/18 , A61K31/4184 , A61K31/44 , A61K31/473 , C07C311/13 , C07C311/20 , C07C311/29 , C07C2601/02 , C07C2601/14 , C07D207/323 , C07D209/14 , C07D213/40 , C07D213/53 , C07D213/71 , C07D213/74 , C07D213/75 , C07D215/12 , C07D215/36 , C07D215/38 , C07D217/02 , C07D231/56 , C07D233/64 , C07D277/28 , C07D401/12 , C07D401/14 , C07D417/12
摘要： The invention relates to novel sulfonylamino-acetic acid derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of such compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as orexin receptor antagonists.
摘要翻译： 本发明涉及新型磺酰基氨基 - 乙酸衍生物及其在制备药物组合物中作为活性成分的用途。 本发明还涉及包括制备这种化合物的方法，含有一种或多种这些化合物的药物组合物，特别是其作为食欲素受体拮抗剂的用途的相关方面。
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![7 8 9 10-tetrahydro-6h-azepino, 6 7 8 9-tetrahydro-pyrido and 2 3-dihydro-2h-pyrrolo[2 1-b]-quinazolinone derivates](/abs-image/US/2005/01/13/US20050009852A1/abs.jpg.150x150.jpg)
6.发明申请7 8 9 10-tetrahydro-6h-azepino, 6 7 8 9-tetrahydro-pyrido and 2 3-dihydro-2h-pyrrolo[2 1-b]-quinazolinone derivates 失效7,89,10-四氢-6h氮杂，6,7,8-9-四氢 - 吡啶并且2,3-二氢-2H-吡咯并[2,1-b] - 喹唑啉酮衍生物公开(公告)号：US20050009852A1
公开(公告)日：2005-01-13
申请号：US10489350
申请日：2003-07-08
申请人： Hamed Aissaoui , Martine Clozel , Walter Fischli , Ralf Koberstein , Thierry Siffelen , Thomas Weller
发明人： Hamed Aissaoui , Martine Clozel , Walter Fischli , Ralf Koberstein , Thierry Siffelen , Thomas Weller
IPC分类号： A61K31/519 , A61K31/522 , A61K45/00 , A61P3/04 , A61P9/00 , A61P25/18 , A61P25/20 , A61P25/24 , A61P35/00 , A61P43/00 , C07D471/04 , C07D487/04
CPC分类号： C07D471/04 , A61K31/519 , C07D487/04
摘要： The invention relates to novel 7,8,9,10-tetrahydro-6H-azepino, 6,7,8,9-tetrahydro-pyrido and 2,3-dihydro-2H-pyrrolo[2, 1-b]-quinazolinone derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as orexin receptor antagonists.
摘要翻译： 本发明涉及新的7,8,9,10-四氢-6H-吖庚因，6,7,8,9-四氢 - 吡啶并2,3-二氢-2H-吡咯并[1,2-b] - 喹唑啉酮衍生物 以及它们作为药物组合物制备中的活性成分的用途。 本发明还涉及包括制备化合物的方法，含有一种或多种这些化合物的药物组合物，特别是其作为食欲素受体拮抗剂的用途的相关方面。
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公开(公告)号：US20100256182A1
公开(公告)日：2010-10-07
申请号：US12815605
申请日：2010-06-15
IPC分类号： A61K31/47 , C07D217/18 , A61P25/20 , A61P3/04
CPC分类号： C07D217/18 , C07D401/06
摘要： The invention relates to novel 1,2,3,4-tetrahydroisoquinoline derivatives of formula (I) wherein R1, R2, R3 and X are as defined in the claims, and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and methods of treatment comprising administration of said compounds to a mammal.
摘要翻译： 本发明涉及式（I）的新的1,2,3,4-四氢异喹啉衍生物，其中R 1，R 2，R 3和X如权利要求中所定义，及其作为药物组合物制备中的活性成分的用途。 本发明还涉及包括制备化合物的方法，含有一种或多种这些化合物的药物组合物和包括向哺乳动物施用所述化合物的治疗方法的相关方面。
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公开(公告)号：US07763638B2
公开(公告)日：2010-07-27
申请号：US10598449
申请日：2005-02-23
IPC分类号： C07D217/18 , A61K31/47
CPC分类号： C07D217/18 , C07D401/06
摘要： The invention relates to novel 1,2,3,4-tetrahydroisoquinoline derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and methods of treatment comprising administration of said compounds to a mammal.
摘要翻译： 本发明涉及新型1,2,3,4-四氢异喹啉衍生物及其在制备药物组合物中作为活性成分的用途。 本发明还涉及包括制备化合物的方法，含有一种或多种这些化合物的药物组合物和包括向哺乳动物施用所述化合物的治疗方法的相关方面。
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公开(公告)号：US07435815B2
公开(公告)日：2008-10-14
申请号：US11756008
申请日：2007-05-31
申请人： Hamed Aissaoui , Martine Clozel , Walter Fischli , Ralf Koberstein , Thierry Sifferlen , Thomas Weller
发明人： Hamed Aissaoui , Martine Clozel , Walter Fischli , Ralf Koberstein , Thierry Sifferlen , Thomas Weller
IPC分类号： C07C311/13 , C07C311/20 , C07D213/76 , C07D213/75 , C07D215/38
CPC分类号： C07C311/21 , A61K31/18 , A61K31/4184 , A61K31/44 , A61K31/473 , C07C311/13 , C07C311/20 , C07C311/29 , C07C2601/02 , C07C2601/14 , C07D207/323 , C07D209/14 , C07D213/40 , C07D213/53 , C07D213/71 , C07D213/74 , C07D213/75 , C07D215/12 , C07D215/36 , C07D215/38 , C07D217/02 , C07D231/56 , C07D233/64 , C07D277/28 , C07D401/12 , C07D401/14 , C07D417/12
摘要： The invention relates to novel sulfonylamino-acetic acid derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of such compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as orexin receptor antagonists.
摘要翻译： 本发明涉及新型磺酰基氨基 - 乙酸衍生物及其在制备药物组合物中作为活性成分的用途。 本发明还涉及包括制备这种化合物的方法，含有一种或多种这些化合物的药物组合物，特别是其作为食欲素受体拮抗剂的用途的相关方面。
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10.发明申请Tetrahydroisoquinolyl acetamide derivatives for use as orexin receptor antagonists 审中-公开用作食欲素受体拮抗剂的四氢异喹啉基乙酰胺衍生物公开(公告)号：US20060178515A1
公开(公告)日：2006-08-10
申请号：US10549180
申请日：2004-03-23
申请人： Hamed Aissaoui , Martine Clozel , Thomas Weller , Ralf Koberstein , Thierry Sifferlen , Walter Fischli
发明人： Hamed Aissaoui , Martine Clozel , Thomas Weller , Ralf Koberstein , Thierry Sifferlen , Walter Fischli
IPC分类号： C07D217/12
CPC分类号： C07D217/02 , C07D217/04 , C07D217/16 , C07D217/18 , C07D217/20 , C07D405/06
摘要： The invention relates to novel acetamide derivatives of formula (I) and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of such compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as orexin receptor antagonists.
摘要翻译： 本发明涉及式（I）的新型乙酰胺衍生物及其在制备药物组合物中作为活性成分的用途。 本发明还涉及包括制备这种化合物的方法，含有一种或多种这些化合物的药物组合物，特别是其作为食欲素受体拮抗剂的用途的相关方面。
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