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    Substituted indazolyl(indolyl)maleimide derivatives as kinase inhibitors
    8.
    发明申请
    Substituted indazolyl(indolyl)maleimide derivatives as kinase inhibitors 有权
    取代的吲唑基（吲哚基）马来酰亚胺衍生物作为激酶抑制剂

    公开(公告)号：US20050004201A1

    公开(公告)日：2005-01-06

    申请号：US10858212

    申请日：2004-06-01

    申请人： Han-Cheng Zhang ,  Bruce Maryanoff ,  Hong Ye

    发明人： Han-Cheng Zhang ,  Bruce Maryanoff ,  Hong Ye

    IPC分类号： A61K31/416 ,  A61P25/00 ,  C07D401/14 ,  C07D403/14 ,  C07

    CPC分类号： C07D403/14 ,  C07D401/14

    摘要： The present invention is directed to novel indazolyl-substituted pyrroline compounds of Formula (I): R2 is selected from the group consisting of —C1-8alkyl-Z, —C2-8alkenyl-Z and —C2-8alkynyl-Z; wherein the —C1-8alkyl-Z, —C2-8alkenyl-Z and —C2-8alkynyl-Z and Z is a 5 to 6 member aromatic monocyclic heteroaryl ring having from 2 to 4 heteroatoms. These compounds are useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.

    摘要翻译： 本发明涉及式（I）的新的吲唑基取代的吡咯啉化合物：R 2选自-C 1-8烷基-Z，-C 2-8烯基-Z和-C 2-8炔基-Z; 其中-C 1-8烷基-Z，-C 2-8烯基-Z和-C 2-8炔基-Z和Z是具有2至4个杂原子的5至6元芳族单环杂芳基环。 这些化合物可用作激酶或双重激酶抑制剂，用于产生这些化合物的方法和用于治疗或改善激酶或双重激酶介导的病症的方法。