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公开(公告)号:US20070129364A1
公开(公告)日:2007-06-07
申请号:US11634003
申请日:2006-12-05
申请人: Han-Qing Dong , Kenneth Foreman , An-Hu Li , Mark Mulvihill , Bijoy Panicker , Arno Steinig , Kathryn Stolz , Qinghua Weng , Meizhong Jin , Brian Volk , Jing Wang , Ti Wang , James Beard
发明人: Han-Qing Dong , Kenneth Foreman , An-Hu Li , Mark Mulvihill , Bijoy Panicker , Arno Steinig , Kathryn Stolz , Qinghua Weng , Meizhong Jin , Brian Volk , Jing Wang , Ti Wang , James Beard
IPC分类号: A61K31/5377 , A61K31/496 , A61K31/4745 , C07D471/02
CPC分类号: C07D471/04
摘要: Compounds represented by Formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, are inhibitors of least one of the Abl, Aurora-A, Blk, c-Raf, cSRC, Src, PRK2, FGFR3, Flt3, Lck, Mek1, PDK-1, GSK3β, EGFR, p70S6K, BMX, SGK, CaMKII, Tie-2, IGF-1R, Ron, Met, and KDR kinases in animals, including humans, for the treatment and/or prevention of various diseases and conditions such as cancer.
摘要翻译: 由式(I)表示的化合物或其立体异构体或其药学上可接受的盐是Abl,Aurora-A,Blk,c-Raf,cSRC,Src,PRK2,FGFR3,Flt3,Lck,Mek1,PDK中的至少一种的抑制剂 -1,GSK3beta,EGFR,p70S6K,BMX,SGK,CaMKII,Tie-2,IGF-1R,Ron,Met和KDR激酶,用于治疗和/或预防各种疾病和病症, 癌症。
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公开(公告)号:US20090197864A1
公开(公告)日:2009-08-06
申请号:US12366743
申请日:2009-02-06
申请人: An-Hu Li , Arno G. Steinig , Andrew Kleinberg , Qinghua Weng , Mark J. Mulvihill , Jing Wang , Xin Chen , Ti Wang , Hanqing Dong , Meizhong Jin
发明人: An-Hu Li , Arno G. Steinig , Andrew Kleinberg , Qinghua Weng , Mark J. Mulvihill , Jing Wang , Xin Chen , Ti Wang , Hanqing Dong , Meizhong Jin
IPC分类号: A61K31/4355 , C07D491/048 , A61K31/00 , A61K31/54 , A61K31/5377 , A61K31/506 , A61P35/00
CPC分类号: C07D491/048
摘要: Furo[3,2-c]Pyridine and Thieno[3,2-c]pyridine compounds of Formula I, and pharmaceutically acceptable salts thereof, preparation, intermediates, pharmaceutical compositions, and use, such as in disease treatment, including cancers, including conditions in which EMT is involved, including conditions mediated by protein kinase activity such as RON and/or MET.
摘要翻译: 呋喃并[3,2-c]吡啶和噻吩并[3,2-c]吡啶化合物及其药学上可接受的盐,制剂,中间体,药物组合物和用途,例如疾病治疗包括癌症,包括 涉及EMT的病症,包括蛋白激酶活性介导的病症,如RON和/或MET。
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公开(公告)号:US08022206B2
公开(公告)日:2011-09-20
申请号:US12366743
申请日:2009-02-06
申请人: An-Hu Li , Arno G. Steinig , Andrew Kleinberg , Qinghua Weng , Mark J. Mulvihill , Jing Wang , Xin Chen , Ti Wang , Hanqing Dong , Meizhong Jin
发明人: An-Hu Li , Arno G. Steinig , Andrew Kleinberg , Qinghua Weng , Mark J. Mulvihill , Jing Wang , Xin Chen , Ti Wang , Hanqing Dong , Meizhong Jin
IPC分类号: C07D413/00 , C07D403/00 , C07D471/02
CPC分类号: C07D491/048
摘要: Furo[3,2-c]Pyridine and Thieno[3,2-c]pyridine compounds of Formula I, and pharmaceutically acceptable salts thereof, preparation, intermediates, pharmaceutical compositions, and use, such as in disease treatment, including cancers, including conditions in which EMT is involved, including conditions mediated by protein kinase activity such as RON and/or MET.
摘要翻译: 呋喃并[3,2-c]吡啶和噻吩并[3,2-c]吡啶化合物及其药学上可接受的盐,制剂,中间体,药物组合物和用途,例如疾病治疗包括癌症,包括 涉及EMT的病症,包括蛋白激酶活性介导的病症,如RON和/或MET。
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