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公开(公告)号：US20070129364A1
公开(公告)日：2007-06-07
申请号：US11634003
申请日：2006-12-05
申请人： Han-Qing Dong , Kenneth Foreman , An-Hu Li , Mark Mulvihill , Bijoy Panicker , Arno Steinig , Kathryn Stolz , Qinghua Weng , Meizhong Jin , Brian Volk , Jing Wang , Ti Wang , James Beard
发明人： Han-Qing Dong , Kenneth Foreman , An-Hu Li , Mark Mulvihill , Bijoy Panicker , Arno Steinig , Kathryn Stolz , Qinghua Weng , Meizhong Jin , Brian Volk , Jing Wang , Ti Wang , James Beard
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/4745 , C07D471/02
CPC分类号： C07D471/04
摘要： Compounds represented by Formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, are inhibitors of least one of the Abl, Aurora-A, Blk, c-Raf, cSRC, Src, PRK2, FGFR3, Flt3, Lck, Mek1, PDK-1, GSK3β, EGFR, p70S6K, BMX, SGK, CaMKII, Tie-2, IGF-1R, Ron, Met, and KDR kinases in animals, including humans, for the treatment and/or prevention of various diseases and conditions such as cancer.
摘要翻译： 由式（I）表示的化合物或其立体异构体或其药学上可接受的盐是Abl，Aurora-A，Blk，c-Raf，cSRC，Src，PRK2，FGFR3，Flt3，Lck，Mek1，PDK中的至少一种的抑制剂 -1，GSK3beta，EGFR，p70S6K，BMX，SGK，CaMKII，Tie-2，IGF-1R，Ron，Met和KDR激酶，用于治疗和/或预防各种疾病和病症， 癌症。
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公开(公告)号：US20070112005A1
公开(公告)日：2007-05-17
申请号：US11599663
申请日：2006-11-15
申请人： Xin Chen , Heather Coate , Andrew Crew , Han-Qing Dong , Ayako Honda , Mark Mulvihill , Paula Tavares , Jing Wang , Douglas Werner , Kristen Mulvihill , Kam Siu , Bijoy Panicker , Apoorba Bharadwaj , Lee Arnold , Meizhong Jin , Brian Volk , Qinghua Weng , James Beard
发明人： Xin Chen , Heather Coate , Andrew Crew , Han-Qing Dong , Ayako Honda , Mark Mulvihill , Paula Tavares , Jing Wang , Douglas Werner , Kristen Mulvihill , Kam Siu , Bijoy Panicker , Apoorba Bharadwaj , Lee Arnold , Meizhong Jin , Brian Volk , Qinghua Weng , James Beard
IPC分类号： A61K31/498 , A61K31/53 , C07D487/12
CPC分类号： C07D487/04 , A61K31/5025 , C07D253/07 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14
摘要： Compounds represented by Formula (I) or a pharmaceutically acceptable salt thereof, are inhibitors of mTOR and useful in the treatment of cancer.
摘要翻译： 由式（I）表示的化合物或其药学上可接受的盐是mTOR的抑制剂，可用于治疗癌症。
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公开(公告)号：US07700594B2
公开(公告)日：2010-04-20
申请号：US11599663
申请日：2006-11-15
申请人： Xin Chen , Heather Coate , Andrew Philip Crew , Han-Qing Dong , Ayako Honda , Mark Joseph Mulvihill , Paula A. R. Tavares , Jing Wang , Douglas S. Werner , Kristen Michelle Mulvihill , Kam W. Siu , Bijoy Panicker , Apoorba Bharadwaj , Lee D. Arnold , Meizhong Jin , Brian Volk , Qinghua Weng , James David Beard
发明人： Xin Chen , Heather Coate , Andrew Philip Crew , Han-Qing Dong , Ayako Honda , Mark Joseph Mulvihill , Paula A. R. Tavares , Jing Wang , Douglas S. Werner , Kristen Michelle Mulvihill , Kam W. Siu , Bijoy Panicker , Apoorba Bharadwaj , Lee D. Arnold , Meizhong Jin , Brian Volk , Qinghua Weng , James David Beard
IPC分类号： C07D487/04 , C07D401/14 , C07D403/04 , A61K31/53 , A61K31/4523 , A61K35/00
CPC分类号： C07D487/04 , A61K31/5025 , C07D253/07 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14
摘要： Compounds represented by Formula (I) or a pharmaceutically acceptable salt thereof, are inhibitors of mTOR and useful in the treatment of cancer.
摘要翻译： 由式（I）表示的化合物或其药学上可接受的盐是mTOR的抑制剂，可用于治疗癌症。
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公开(公告)号：US20110218183A1
公开(公告)日：2011-09-08
申请号：US13106954
申请日：2011-05-13
申请人： Xin Chen , Heather Coate , Andrew Philip Crew , Han-Qing Dong , Ayako Honda , Mark Joseph Mulvihill , Paula A.R. Tavares , Jing Wang , Douglas S. Werner , Kristen Michelle Mulvihill , Kem W. Siu , Bijoy Panicker , Apoorba Bharadwaj , Lee D. Arnold , Meizhong Jin , Brian Volk , Qinghua Weng , James David Beard
发明人： Xin Chen , Heather Coate , Andrew Philip Crew , Han-Qing Dong , Ayako Honda , Mark Joseph Mulvihill , Paula A.R. Tavares , Jing Wang , Douglas S. Werner , Kristen Michelle Mulvihill , Kem W. Siu , Bijoy Panicker , Apoorba Bharadwaj , Lee D. Arnold , Meizhong Jin , Brian Volk , Qinghua Weng , James David Beard
IPC分类号： A61K31/4985 , C07D487/04 , A61K31/53 , C07D519/00 , A61K31/5377 , A61P35/00
CPC分类号： C07D487/04 , A61K31/5025 , C07D253/07 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14
摘要： Compounds represented by Formula (I) or a pharmaceutically acceptable salt thereof, are inhibitors of mTOR and useful in the treatment of cancer.
摘要翻译： 由式（I）表示的化合物或其药学上可接受的盐是mTOR的抑制剂，可用于治疗癌症。
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公开(公告)号：US20090163468A1
公开(公告)日：2009-06-25
申请号：US12326536
申请日：2008-12-02
申请人： Xin Chen , Heather Coate , Andrew Philip Crew , Han-Qing Dong , Ayako Honda , Mark Joesph Mulvihill , Paula A.R. Tavares , Jing Wang , Douglas S. Werner , Kristen Michelle Mulvihill , Kam W. Siu , Bijoy Panicker , Apoorba Bharadwaj , Lee D. Arnold , Meizhong Jin , Brian Volk , Qinghua Weng , James David Beard
发明人： Xin Chen , Heather Coate , Andrew Philip Crew , Han-Qing Dong , Ayako Honda , Mark Joesph Mulvihill , Paula A.R. Tavares , Jing Wang , Douglas S. Werner , Kristen Michelle Mulvihill , Kam W. Siu , Bijoy Panicker , Apoorba Bharadwaj , Lee D. Arnold , Meizhong Jin , Brian Volk , Qinghua Weng , James David Beard
IPC分类号： A61K31/397 , C07D487/02 , A61K31/4985 , A61K31/5377 , C07F5/02 , A61P19/02 , A61P37/00 , A61P35/00 , C07D253/06 , C07D413/14 , A61K31/53
CPC分类号： C07D487/04 , A61K31/5025 , C07D253/07 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14
摘要： Compounds represented by Formula (I) or a pharmaceutically acceptable salt thereof, are inhibitors of mTOR and useful in the treatment of cancer.
摘要翻译： 由式（I）表示的化合物或其药学上可接受的盐是mTOR的抑制剂，可用于治疗癌症。
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公开(公告)号：US08796455B2
公开(公告)日：2014-08-05
申请号：US13767947
申请日：2013-02-15
申请人： Xin Chen , Heather Coate , Andrew Philip Crew , Han-Qing Dong , Ayako Honda , Mark Joseph Mulvihill , Paula A. R. Tavares , Jing Wang , Douglas S. Werner , Kristen Michelle Mulvihill , Kam W. Siu , Bijoy Panicker , Lee D. Arnold , Meizhong Jin , Brian Volk , Qinghua Weng , James David Beard
发明人： Xin Chen , Heather Coate , Andrew Philip Crew , Han-Qing Dong , Ayako Honda , Mark Joseph Mulvihill , Paula A. R. Tavares , Jing Wang , Douglas S. Werner , Kristen Michelle Mulvihill , Kam W. Siu , Bijoy Panicker , Apoorba Bharadwaj , Lee D. Arnold , Meizhong Jin , Brian Volk , Qinghua Weng , James David Beard
IPC分类号： C07D487/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , A61K31/5025 , A61P19/02 , A61P35/00
CPC分类号： C07D487/04 , A61K31/5025 , C07D253/07 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14
摘要： Compounds represented by Formula (I) or a pharmaceutically acceptable salt thereof, are inhibitors of mTOR and useful in the treatment of cancer.
摘要翻译： 由式（I）表示的化合物或其药学上可接受的盐是mTOR的抑制剂，可用于治疗癌症。
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公开(公告)号：US20130165651A1
公开(公告)日：2013-06-27
申请号：US13767947
申请日：2013-02-15
申请人： Xin Chen , Heather Coate , Andrew Philip Crew , Han-Qing Dong , Ayako Honda , Mark Joseph Mulvihill , Paula A.R. Tavares , Jing Wang , Douglas S. Werner , Kristen Michelle Mulvihill , Kam W. Siu , Bijoy Panicker , Apoorba Bharadwaj , Lee D. Arnold , Meizhong Jin , Brian Volk , Qinghua Weng , James David Beard
发明人： Xin Chen , Heather Coate , Andrew Philip Crew , Han-Qing Dong , Ayako Honda , Mark Joseph Mulvihill , Paula A.R. Tavares , Jing Wang , Douglas S. Werner , Kristen Michelle Mulvihill , Kam W. Siu , Bijoy Panicker , Apoorba Bharadwaj , Lee D. Arnold , Meizhong Jin , Brian Volk , Qinghua Weng , James David Beard
IPC分类号： C07D487/04
CPC分类号： C07D487/04 , A61K31/5025 , C07D253/07 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14
摘要： Compounds represented by Formula (I) or a pharmaceutically acceptable salt thereof, are inhibitors of mTOR and useful in the treatment of cancer.
摘要翻译： 由式（I）表示的化合物或其药学上可接受的盐是mTOR的抑制剂，可用于治疗癌症。
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公开(公告)号：US20060084654A1
公开(公告)日：2006-04-20
申请号：US10965182
申请日：2004-10-14
申请人： Patricia Beck , Cara Cesario , Matthew Cox , Han-Qing Dong , Kenneth Foreman , Mark Mulvihill , Anthony Nigro , Lydia Saroglou , Arno Steinig , Yingchuan Sun , Qinghua Weng , Douglas Werner , Robin Wilkes , Jonathan Williams
发明人： Patricia Beck , Cara Cesario , Matthew Cox , Han-Qing Dong , Kenneth Foreman , Mark Mulvihill , Anthony Nigro , Lydia Saroglou , Arno Steinig , Yingchuan Sun , Qinghua Weng , Douglas Werner , Robin Wilkes , Jonathan Williams
IPC分类号： A61K31/498 , C07D487/04
CPC分类号： C07D487/04
摘要： Compounds of the formula and pharmaceutically acceptable salts thereof, wherein Q1 and R1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of various diseases and conditions that respond to treatment by inhibition of tyrosine kinases.
摘要翻译： 式I化合物及其药学上可接受的盐，其中Q 1和R 1在本文中定义，抑制IGF-1R酶，并且可用于治疗和/或预防 通过抑制酪氨酸激酶对治疗作出反应的各种疾病和病症。
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公开(公告)号：US20080227788A9
公开(公告)日：2008-09-18
申请号：US10965182
申请日：2004-10-14
申请人： Patricia Beck , Cara Cesario , Matthew Cox , Han-Qing Dong , Kenneth Foreman , Mark Mulvihill , Anthony Nigro , Lydia Saroglou , Arno Steinig , Yingchuan Sun , Qinghua Weng , Douglas Werner , Robin Wilkes , Jonathan Williams
发明人： Patricia Beck , Cara Cesario , Matthew Cox , Han-Qing Dong , Kenneth Foreman , Mark Mulvihill , Anthony Nigro , Lydia Saroglou , Arno Steinig , Yingchuan Sun , Qinghua Weng , Douglas Werner , Robin Wilkes , Jonathan Williams
IPC分类号： A61K31/498 , C07D487/04
CPC分类号： C07D487/04
摘要： Compounds of the formula and pharmaceutically acceptable salts thereof, wherein Q1 and R1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of various diseases and conditions that respond to treatment by inhibition of tyrosine kinases.
摘要翻译： 式I化合物及其药学上可接受的盐，其中Q 1和R 1在本文中定义，抑制IGF-1R酶，并且可用于治疗和/或预防 通过抑制酪氨酸激酶对治疗作出反应的各种疾病和病症。
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公开(公告)号：US20110190496A1
公开(公告)日：2011-08-04
申请号：US13085722
申请日：2011-04-13
申请人： Xin Chen , Heather Coate , Andrew Philip Crew , Han-Qing Dong , Ayako Honda , Mark Joseph Mulvihill , Paula A.R. Tavares , Jing Wang , Douglas S. Werner , Kristen Michelle Mulvihill , Kam W. Siu , Bijoy Panicker , Apoorba Bharadwaj , Lee D. Arnold , Meizhong Jin , Brian Volk , Quinghua Weng , James David Beard
发明人： Xin Chen , Heather Coate , Andrew Philip Crew , Han-Qing Dong , Ayako Honda , Mark Joseph Mulvihill , Paula A.R. Tavares , Jing Wang , Douglas S. Werner , Kristen Michelle Mulvihill , Kam W. Siu , Bijoy Panicker , Apoorba Bharadwaj , Lee D. Arnold , Meizhong Jin , Brian Volk , Quinghua Weng , James David Beard
IPC分类号： C07D487/04 , C07F5/02 , C07D253/06
CPC分类号： C07D487/04 , A61K31/5025 , C07D253/07 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14
摘要： Compounds represented by Formula (I) or a pharmaceutically acceptable salt thereof, are inhibitors of mTOR and useful in the treatment of cancer.
摘要翻译： 由式（I）表示的化合物或其药学上可接受的盐是mTOR的抑制剂，可用于治疗癌症。
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