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    Native soft tissue matrix for therapeutic applications
    1.
    发明申请
    Native soft tissue matrix for therapeutic applications 审中-公开
    用于治疗应用的原生软组织基质

    公开(公告)号：US20050288796A1

    公开(公告)日：2005-12-29

    申请号：US10874402

    申请日：2004-06-23

    申请人： Hani Awad ,  Bradley Estes ,  Farshid Guilak

    发明人： Hani Awad ,  Bradley Estes ,  Farshid Guilak

    IPC分类号： A61F2/00 ,  A61F2/02

    CPC分类号： A61L27/3612 ,  A61F2/0022 ,  A61F2/0036 ,  A61F2/02 ,  A61F2210/0004 ,  A61F2210/009 ,  A61F2240/001 ,  A61F2250/0004 ,  A61F2250/0068 ,  A61L2/081 ,  A61L27/3804 ,  A61L27/3817 ,  A61L27/3834 ,  A61L27/54 ,  A61L27/56 ,  A61L2202/21 ,  A61L2400/06 ,  A61L2430/06 ,  A61L2430/34

    摘要： A product for implantation within a soft tissue site of the human or animal body comprises a pulverized or morselized matrix of a substantially non-mineralized native soft tissue (NSTM) of the human or animal body, provided in a therapeutic amount to induce growth of native tissue or organs and healing at the tissue site. The NSTM is composed of at least one soft tissue selected from the group consisting of cartilage, meniscus, intervertebral disc, ligament, tendon, muscle, fascia, periosteum, pericardium, perichondrium, skin, nerve, blood vessels, and heart valves or from organs such as bladder, lung, kidney, liver, pancreas, thyroid, or thymus. Preferably, the NSTM is composed of a soft tissue of the same type of tissue native to the repair site. In another embodiment, the NSTM includes soft tissue of a different type than the tissue repair site.

    摘要翻译： 用于植入在人或动物体的软组织部位内的产品包括以人或动物体的基本上非矿化的天然软组织（NSTM）的粉碎或微粒化基质，其以治疗量提供以诱导天然 组织或器官，并在组织部位愈合。 NSTM由选自软骨，半月板，椎间盘，韧带，肌腱，筋膜，骨膜，心包膜，软骨膜，皮肤，神经，血管和心脏瓣膜或从器官组成的组中的至少一种软组织组成 如膀胱，肺，肾，肝，胰腺，甲状腺或胸腺。 优选地，NSTM由修复部位原生的相同类型的组织的软组织组成。 在另一个实施方案中，NSTM包括与组织修复部位不同类型的软组织。

    Native soft tissue matrix for therapeutic applications
    2.
    发明授权
    Native soft tissue matrix for therapeutic applications 有权

    公开(公告)号：US11357889B2

    公开(公告)日：2022-06-14

    申请号：US15444445

    申请日：2017-02-28

    申请人： Hani Awad ,  Bradley T. Estes ,  Farshid Guilak

    发明人： Hani Awad ,  Bradley T. Estes ,  Farshid Guilak

    IPC分类号： A61L27/36 ,  A61F2/00 ,  A61F2/02 ,  A61L2/08 ,  A61L27/38 ,  A61L27/54 ,  A61L27/56

    摘要： A method is used for preparing a product for use in repairing a lesion or defect at a tissue site in a human or animal patient body. The method includes obtaining tissue from a donor human or animal body and freezing the obtained tissue. The method further includes pulverizing the frozen tissue and suspending the pulverized tissue in a fluid. The method further includes homogenizing the tissue suspension and precipitating tissue particles from the homogenized tissue suspension. The method further includes re-suspending the precipitated tissue particles and lyophilizing the tissue re-suspension to provide the product to be used in repairing the lesion or defect.

    NATIVE SOFT TISSUE MATRIX FOR THERAPEUTIC APPLICATIONS
    3.
    发明申请
    NATIVE SOFT TISSUE MATRIX FOR THERAPEUTIC APPLICATIONS 有权

    公开(公告)号：US20220305174A1

    公开(公告)日：2022-09-29

    申请号：US17806626

    申请日：2022-06-13

    申请人： Hani Awad ,  Bradley T. Estes ,  Farshid Guilak

    发明人： Hani Awad ,  Bradley T. Estes ,  Farshid Guilak

    IPC分类号： A61L27/36 ,  A61F2/00 ,  A61F2/02 ,  A61L2/08 ,  A61L27/38 ,  A61L27/54 ,  A61L27/56

    摘要： A product for implantation within a soft tissue site of the human or animal body comprises a matrix of pulverized or morselized substantially non-mineralized native soft tissue (NSTM) of the human or animal body, provided in a therapeutic amount to induce growth of native tissue or organs and healing at the tissue site. The NSTM is composed of at least one soft tissue selected from the group consisting of cartilage, meniscus, intervertebral disc, ligament, tendon, muscle, fascia, periosteum, pericardium, perichondrium, skin, nerve, blood vessels, and heart valves or from organs such as bladder, lung, kidney, liver, pancreas, thyroid, or thymus. Preferably, the NSTM is composed of a soft tissue of the same type of tissue native to the repair site.