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公开(公告)号：US20090075895A1
公开(公告)日：2009-03-19
申请号：US12325348
申请日：2008-12-01
申请人： Hanne Nedergaard , Lars Linggaard Hansen , Niels Kristian Klausen , Troels Kornfelt , James M. Flink
发明人： Hanne Nedergaard , Lars Linggaard Hansen , Niels Kristian Klausen , Troels Kornfelt , James M. Flink
CPC分类号： A61K47/183 , A61K9/0019 , A61K47/26
摘要： The invention concerns a composition comprising; i) Modified Factor VII; ii) an agent suitable for keeping the pH of said composition in the range of 4 to 7 when said composition is dissolved in water; and iii) a moisture content of at the most 3%.
摘要翻译： 本发明涉及一种组合物，其包含： i）修饰因子VII; ii）当所述组合物溶解在水中时，适于将所述组合物的pH保持在4至7范围内的试剂; 和iii）水分含量最多3％。
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公开(公告)号：US08299029B2
公开(公告)日：2012-10-30
申请号：US11526503
申请日：2006-09-25
IPC分类号： A61K38/361
CPC分类号： A61K38/4846 , A61K9/0019 , A61K9/19 , A61K47/02 , A61K47/08 , A61K47/10 , A61K47/183 , A61K47/20 , A61K47/22 , A61K47/26 , A61K47/34 , C12Y304/21021 , A61K2300/00
摘要： The invention relates to chemically as well as physically stable compositions comprising Factor VII or a Factor VII-related polypeptide such that these compositions can be stored, handled and used at room temperature.
摘要翻译： 本发明涉及包含因子VII或因子VII相关多肽的化学以及物理稳定的组合物，使得这些组合物可以在室温下储存，处理和使用。
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公开(公告)号：US20080227715A1
公开(公告)日：2008-09-18
申请号：US12154088
申请日：2008-05-20
IPC分类号： A61K38/36 , C07K14/745
CPC分类号： A61K47/02 , A61K9/0019 , A61K31/19 , A61K47/183
摘要： The invention concerns a liquid aqueous composition comprising (i) a factor VII polypeptide, (ii) an agent suitable for keeping pH in the range of from about 4.0 to about 9.0; (iii) an agent selected from the group consisting of: a calcium salt, a magnesium salt, or a mixture thereof; wherein the concentration of (iii) is less than 15 mM; and (iv) An ionic strength modifying agent; wherein the ionic strength of the composition is at least 200 mM.
摘要翻译： 本发明涉及一种液体含水组合物，其包含（i）因子VII多肽，（ii）适于将pH保持在约4.0至约9.0范围内的试剂; （iii）选自以下的试剂：钙盐，镁盐或其混合物; 其中（iii）的浓度小于15mM; 和（iv）离子强度改性剂; 其中所述组合物的离子强度为至少200mM。
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公开(公告)号：US08658597B2
公开(公告)日：2014-02-25
申请号：US12407266
申请日：2009-03-19
CPC分类号： A61K38/4846 , A61K9/0019 , A61K9/08 , A61K9/19 , A61K38/36 , A61K38/37 , A61K38/4866 , A61K47/183 , A61K47/20 , A61K47/26 , C12Y304/21021
摘要： The invention relates to chemically as well as physically stable kits and compositions comprising polypeptides, in particular Factor VII or Factor VII-related polypeptides, such that these compositions can be stored, handled and used at room temperature.
摘要翻译： 本发明涉及化学和物理稳定的试剂盒和组合物，其包含多肽，特别是因子VII或因子VII相关多肽，使得这些组合物可以在室温下储存，处理和使用。
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公开(公告)号：US08461116B2
公开(公告)日：2013-06-11
申请号：US13232322
申请日：2011-09-14
CPC分类号： A61K47/02 , A61K9/0019 , A61K38/4846 , A61K47/183
摘要： A liquid aqueous composition comprising (i) a factor VII polypeptide; (ii) an agent suitable for keeping pH in the range of from about 4.0 to about 8.0; (iii) an agent selected from the list of: a calcium salt, a magnesium salt, or a mixture thereof; wherein the concentration of (iii) is at least 15 mM is described.
摘要翻译： 一种液体含水组合物，其包含（i）因子VII多肽; （ii）适于将pH保持在约4.0至约8.0范围内的试剂; （iii）选自以下列表的试剂：钙盐，镁盐或其混合物; 其中描述（iii）的浓度为至少15mM。
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公开(公告)号：US20130017184A1
公开(公告)日：2013-01-17
申请号：US13573310
申请日：2012-09-10
CPC分类号： A61K38/4846 , A61K9/0019 , A61K9/19 , A61K47/02 , A61K47/08 , A61K47/10 , A61K47/183 , A61K47/20 , A61K47/22 , A61K47/26 , A61K47/34 , C12Y304/21021 , A61K2300/00
摘要： The invention relates to chemically as well as physically stable compositions comprising Factor VII or a Factor VII-related polypeptide such that these compositions can be stored, handled and used at room temperature.
摘要翻译： 本发明涉及包含因子VII或因子VII相关多肽的化学以及物理稳定的组合物，使得这些组合物可以在室温下储存，处理和使用。
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公开(公告)号：US20060183683A1
公开(公告)日：2006-08-17
申请号：US11304429
申请日：2005-12-15
申请人： Birthe Hansen , Michael Jensen , Troels Kornfelt
发明人： Birthe Hansen , Michael Jensen , Troels Kornfelt
CPC分类号： A61K47/02 , A61K9/0019 , A61K31/19 , A61K47/183
摘要： The invention concerns a liquid aqueous composition comprising (i) a factor VII polypeptide, (ii) an agent suitable for keeping pH in the range of from about 4.0 to about 9.0; (iii) an agent selected from the group consisting of: a calcium salt, a magnesium salt, or a mixture thereof; wherein the concentration of (iii) is less than 15 mM; and (iv) An ionic strength modifying agent; wherein the ionic strength of the composition is at least 200 mM.
摘要翻译： 本发明涉及一种液体含水组合物，其包含（i）因子VII多肽，（ii）适于将pH保持在约4.0至约9.0范围内的试剂; （iii）选自以下的试剂：钙盐，镁盐或其混合物; 其中（iii）的浓度小于15mM; 和（iv）离子强度改性剂; 其中所述组合物的离子强度为至少200mM。
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公开(公告)号：US20120004176A1
公开(公告)日：2012-01-05
申请号：US13232322
申请日：2011-09-14
CPC分类号： A61K47/02 , A61K9/0019 , A61K38/4846 , A61K47/183
摘要： A liquid aqueous composition comprising (i) a factor VII polypeptide, (ii) an agent suitable for keeping pH in the range of from about 4.0 to about 8.0; (iii) an agent selected from the list of: a calcium salt, a magnesium salt, or a mixture thereof; wherein the concentration of (iii) is at least 15 mM.
摘要翻译： 一种液体含水组合物，其包含（i）VII因子多肽，（ii）适于将pH保持在约4.0至约8.0范围内的试剂; （iii）选自以下列表的试剂：钙盐，镁盐或其混合物; 其中（iii）的浓度为至少15mM。
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公开(公告)号：US20090181895A1
公开(公告)日：2009-07-16
申请号：US12407266
申请日：2009-03-19
CPC分类号： A61K38/4846 , A61K9/0019 , A61K9/08 , A61K9/19 , A61K38/36 , A61K38/37 , A61K38/4866 , A61K47/183 , A61K47/20 , A61K47/26 , C12Y304/21021
摘要： The invention relates to chemically as well as physically stable kits and compositions comprising polypeptides, in particular Factor VII or Factor VII-related polypeptides, such that these compositions can be stored, handled and used at room temperature.
摘要翻译： 本发明涉及化学和物理稳定的试剂盒和组合物，其包含多肽，特别是因子VII或因子VII相关多肽，使得这些组合物可以在室温下储存，处理和使用。
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公开(公告)号：US20060160720A1
公开(公告)日：2006-07-20
申请号：US11284709
申请日：2005-11-22
CPC分类号： A61K38/4846
摘要： Provided are storage containers for proteinaceous pharmaceutical compositions which are characterized in, among other things, comprising (i) a wall portion, wherein an inner wall material thereof is selected from silica-coated glass, silicone-coated glass, polymers of non-cyclic olefins, cycloolefin polymers and cycloolefin/linear olefin copolymers and (ii) one or more closure portions not constituting part of the wall portion, and which contains a formulation of a protein. Also provided are new methods of storing proteinaceous compositions. In one aspect, the stored protein is characterized as having an amino-terminal γ-carboxyglutamic acid (Gla) domain with 9-12 Gla residues.
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