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公开(公告)号：US20090028799A1
公开(公告)日：2009-01-29
申请号：US12279095
申请日：2007-02-13
申请人： Hanno Priebe
发明人： Hanno Priebe
IPC分类号： A61K49/00 , C07C237/30
CPC分类号： C07C237/46 , A61K49/0442
摘要： The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing a hydrophilic aliphatic central moiety allowing for the arrangement of three iodinated phenyl groups bound thereto. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging and to contrast media containing such compounds.
摘要翻译： 本发明涉及一类化合物和含有这些化合物的诊断组合物，其中化合物是含碘化合物。 更具体地说，含碘化合物是含有亲水性脂族中心部分的化合物，允许与其结合的三个碘化苯基的排列。 本发明还涉及这种诊断组合物作为造影剂在诊断成像中的用途，特别是在X射线成像中以及含有这种化合物的造影剂的用途。
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公开(公告)号：US08067637B2
公开(公告)日：2011-11-29
申请号：US12279095
申请日：2007-02-13
申请人： Hanno Priebe
发明人： Hanno Priebe
IPC分类号： C07C233/05 , A61K49/04
CPC分类号： C07C237/46 , A61K49/0442
摘要： The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing a hydrophilic aliphatic central moiety allowing for the arrangement of three iodinated phenyl groups bound thereto. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging and to contrast media containing such compounds.
摘要翻译： 本发明涉及一类化合物和含有这些化合物的诊断组合物，其中化合物是含碘化合物。 更具体地说，含碘化合物是含有亲水性脂族中心部分的化合物，允许与其结合的三个碘化苯基的排列。 本发明还涉及这种诊断组合物作为造影剂在诊断成像中的用途，特别是在X射线成像中以及含有这种化合物的造影剂的用途。
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公开(公告)号：US20080305042A1
公开(公告)日：2008-12-11
申请号：US12095923
申请日：2006-12-05
申请人： Michel Gacek , Hanno Priebe , Nigel John Osborn
发明人： Michel Gacek , Hanno Priebe , Nigel John Osborn
CPC分类号： C07B59/001 , A61K51/0402 , A61K51/1282
摘要： The present invention provides a method for the preparation of radioisotopically-labelled imaging agent compositions. The method uses precursors which are bound to soluble polymers, so that the radiolabelling reaction is carried out in solution. Also described are radiopharmaceutical compositions, automated versions of the radiolabelling method and disposable cassettes for use in the automated method.
摘要翻译： 本发明提供了一种制备放射性同位素标记显影剂组合物的方法。 该方法使用与可溶性聚合物结合的前体，使得放射性标记反应在溶液中进行。 还描述了放射性药物组合物，放射性标记方法的自动化版本和用于自动化方法的一次性盒。
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公开(公告)号：US20070189971A1
公开(公告)日：2007-08-16
申请号：US11674204
申请日：2007-02-13
申请人： Hanno Priebe
发明人： Hanno Priebe
IPC分类号： A61K49/04
CPC分类号： A61K49/0442
摘要： The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing a cyanuric acid scaffolding moiety allowing for the arrangement of three iodinated phenyl groups bound thereto.The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging and to contrast media containing such compounds.
摘要翻译： 本发明涉及一类化合物和含有这些化合物的诊断组合物，其中化合物是含碘化合物。 更具体地说，含碘化合物是含有氰尿酸支架部分的化合物，其允许与其结合的三个碘化苯基的排列。 本发明还涉及这种诊断组合物作为造影剂在诊断成像中的用途，特别是在X射线成像中以及含有这种化合物的造影剂的用途。
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公开(公告)号：US08071811B2
公开(公告)日：2011-12-06
申请号：US12279086
申请日：2007-02-14
IPC分类号： C07C233/05 , A61K49/04
CPC分类号： C07C237/46
摘要： The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing an aliphatic central moiety allowing for the arrangement of three iodinated phenyl groups bound thereto. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging and to contrast media containing such compounds.
摘要翻译： 本发明涉及一类化合物和含有这些化合物的诊断组合物，其中化合物是含碘化合物。 更具体地，含碘化合物是含有脂族中心部分的化合物，其允许与其结合的三个碘化苯基的排列。 本发明还涉及这种诊断组合物作为造影剂在诊断成像中的用途，特别是在X射线成像中以及含有这种化合物的造影剂的用途。
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公开(公告)号：US20110052504A1
公开(公告)日：2011-03-03
申请号：US12919493
申请日：2009-03-02
申请人： Hanno Priebe
发明人： Hanno Priebe
IPC分类号： A61K49/04 , C07C237/46 , C07D309/10 , A61K49/00 , A61P43/00
CPC分类号： A61K49/04 , A61K49/0438 , B22D11/1287 , B23K9/048 , B23K35/02 , B23K35/0261 , B23K35/30 , B23K35/3086 , B23K2101/04 , B23K2103/04 , C07C235/66 , C07C235/84 , C07D309/10 , C22C38/18 , C22C38/26
摘要： The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing two linked iodinated phenyl groups of the general formula R—N(CO—CH3)XN(CO—CH3)—R and salts or optical active isomers thereof, wherein X denotes a divalent linking moiety with 5 to 10 bridge elements of carbon, oxygen, sulphur and nitrogen separating the acetylated nitrogen atoms, and which may be further substituted by hydroxyl groups, by C1 to C4 alkyl moieties optionally substituted by hydroxyl groups, by C1 to C4 alkoxy groups, by amino groups and by C1 to C4 alkylamino groups, and wherein 2 or 3 carbon bridge elements together with alkyl or alkoxy groups form a cyclopentane, cyclohexane, pentahydropyran or tetrahydrofuran entity which may be alkyl- or hydroxyalkyl-substituted and each R denotes a triiodinated phenyl residue further substituted by hydrophilic moieties. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging, and to contrast media containing such compounds.
摘要翻译： 本发明涉及一类化合物和含有这些化合物的诊断组合物，其中化合物是含碘化合物。 更具体地说，含碘化合物是含有通式R-N（CO-CH 3）XN（CO-CH 3）-R）和其盐或光学活性异构体的两个连接的碘化苯基的化合物，其中X表示二价连接部分 具有5至10个碳元素，氧，硫和氮的桥连元素，分隔乙酰化的氮原子，并且可以进一步被羟基取代，被任选被羟基取代的C1-C4烷基部分，C1-C4烷氧基，C1- 氨基和C1至C4烷基氨基，其中2或3个碳桥元素与烷基或烷氧基一起形成可以是烷基或羟烷基取代的环戊烷，环己烷，五氢吡喃或四氢呋喃实体，每个R表示三碘化苯基 残基被亲水部分进一步取代。 本发明还涉及这种诊断组合物作为造影剂在诊断成像中，特别是在X射线成像中的用途，以及含有这些化合物的造影剂。
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公开(公告)号：US20110008263A1
公开(公告)日：2011-01-13
申请号：US12919490
申请日：2009-02-26
申请人： Hanno Priebe , Audun Aukrust
发明人： Hanno Priebe , Audun Aukrust
IPC分类号： A61K49/04 , C07C235/68 , A61K49/00
CPC分类号： A61K49/0438 , C07C237/46
摘要： The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing two linked iodinated phenyl groups of the general formula R—N(CO—CH3)—X—N(CO—CH3)—R and salts or optical active isomers thereof, wherein X denotes a C3 to C4 straight or branched alkylene moiety wherein the alkylene moiety is substituted by one or two hydroxyl groups, optionally hydroxylated alkyl groups and/or alkoxy groups; and each R denotes a triiodinated phenyl residue further substituted by hydrophilic moieties. The invention also relates to the use of such diagnostic compositions contrast agents in diagnostic imaging and in particular in X-ray imaging, and to contrast media containing such compounds.
摘要翻译： 本发明涉及一类化合物和含有这些化合物的诊断组合物，其中化合物是含碘化合物。 更具体地说，含碘化合物是含有通式R-N（CO-CH 3）-X-N（CO-CH 3）-R）和其盐或光学活性异构体的两个连接的碘化苯基的化合物，其中X表示 C3至C4直链或支链亚烷基部分，其中亚烷基部分被一个或两个羟基，任选羟基化的烷基和/或烷氧基取代; 并且每个R表示进一步被亲水部分取代的三碘化苯基残基。 本发明还涉及这种诊断组合物造影剂在诊断成像中，特别是在X射线成像中的用途，以及含有这些化合物的造影剂。
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公开(公告)号：US07662859B2
公开(公告)日：2010-02-16
申请号：US12031070
申请日：2008-02-14
申请人： Hanno Priebe
发明人： Hanno Priebe
IPC分类号： C07C275/30 , A61K31/175
CPC分类号： C07C275/62 , A61K49/0433
摘要： The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing an aliphatic central moiety allowing for the arrangement of three iodinated phenyl groups bound thereto.The invention also relates to methods of diagnosis and imaging employing such diagnostic compositions as contrast agents in particular in X-ray imaging, and to contrast media containing such compounds.
摘要翻译： 本发明涉及一类化合物和含有这些化合物的诊断组合物，其中化合物是含碘化合物。 更具体地，含碘化合物是含有脂族中心部分的化合物，其允许与其结合的三个碘化苯基的排列。 本发明还涉及使用这种诊断组合物作为造影剂，特别是X射线成像的诊断和成像方法以及含有这些化合物的造影剂。
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公开(公告)号：US20090010853A1
公开(公告)日：2009-01-08
申请号：US12279086
申请日：2007-02-14
IPC分类号： A61K49/04 , C07C233/68
CPC分类号： C07C237/46
摘要： The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing an aliphatic central moiety allowing for the arrangement of three iodinated phenyl groups bound thereto. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging and to contrast media containing such compounds.
摘要翻译： 本发明涉及一类化合物和含有这些化合物的诊断组合物，其中化合物是含碘化合物。 更具体地，含碘化合物是含有脂族中心部分的化合物，其允许与其结合的三个碘化苯基的排列。 本发明还涉及这种诊断组合物作为造影剂在诊断成像中的用途，特别是在X射线成像中以及含有这种化合物的造影剂的用途。
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公开(公告)号：US20080199404A1
公开(公告)日：2008-08-21
申请号：US12031070
申请日：2008-02-14
申请人： Hanno Priebe
发明人： Hanno Priebe
IPC分类号： A61K49/04 , C07C275/62 , C07C273/00 , A61K49/00
CPC分类号： C07C275/62 , A61K49/0433
摘要： The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing an aliphatic central moiety allowing for the arrangement of three iodinated phenyl groups bound thereto.The invention also relates to methods of diagnosis and imaging employing such diagnostic compositions as contrast agents in particular in X-ray imaging, and to contrast media containing such compounds.
摘要翻译： 本发明涉及一类化合物和含有这些化合物的诊断组合物，其中化合物是含碘化合物。 更具体地，含碘化合物是含有脂族中心部分的化合物，其允许与其结合的三个碘化苯基的排列。 本发明还涉及使用这种诊断组合物作为造影剂，特别是X射线成像的诊断和成像方法以及含有这些化合物的造影剂。
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