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公开(公告)号:US20110070253A1
公开(公告)日:2011-03-24
申请号:US12915930
申请日:2010-10-29
申请人: Hans Georg RAMMENSEE , Stefan Stevanovic , Toni Weinschenk , Claudia Trautwein , Jörn Dengjel , Oliver Schoor
发明人: Hans Georg RAMMENSEE , Stefan Stevanovic , Toni Weinschenk , Claudia Trautwein , Jörn Dengjel , Oliver Schoor
IPC分类号: A61K38/10 , C07K7/06 , C07K7/08 , A61K38/08 , A61P35/00 , A61K39/00 , C07K16/00 , A61K38/00 , C07H21/04 , A61K31/7088 , C12N15/63 , C12N5/078 , C12N5/0783 , C12N5/10 , G01N33/53
CPC分类号: C07K7/06 , A61K38/00 , C07K14/47 , C07K14/4748 , C07K14/78
摘要: The invention relates to a tumour-associated peptide with an amino acid sequence that is selected from the group consisting of SEQ ID NO: 1 to SEQ ID NO: 101 of the attached sequence protocol, wherein the peptide has the ability to bind to a molecule of the human major-histocompatibility-complex (MHC) class-I. In addition, the invention relates to the use of the peptides and the nucleic acids encoding for the peptides for the production of a medicament, and for the treatment of tumorous diseases and/or adenomatous diseases. Furthermore, a pharmaceutical composition is described that has at least one of the peptides.
摘要翻译: 本发明涉及具有选自所附序列方案的SEQ ID NO:1至SEQ ID NO:101的氨基酸序列的肿瘤相关肽,其中所述肽具有结合分子的能力 的人类主要组织相容性复合体(MHC)I类。 此外,本发明涉及肽和编码肽的核酸用于制备药物以及用于治疗肿瘤疾病和/或腺瘤性疾病的用途。 此外,描述了具有至少一种肽的药物组合物。