摘要:
This invention relates to novel indazole derivatives of formula I: wherein R1 to R7 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds are FXR modulators and can be used as medicaments.
摘要:
This invention relates to novel cyclopentyl- and cycloheptylpyrazole derivatives of the formula I wherein A and R1 to R4 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. The invention relates also to compositions including these compounds and methods of using the compounds.
摘要:
In a universal drive with a rotatable or linearly movable drive member and piezo actuators supported on a carrier for acting on a leg supported on the drive member and moving the leg in a high-frequency stepping sequence in a drive direction, wherein the carriers are jointly supported on a stator by a pretension member which biases them elastically toward the drive member via an elbow lever mechanism including a first elbow lever and at least a second elbow lever which are both connected to an actuator by a coupling member and this arrangement is such that, with the first elbow lever stretched, the second elbow lever is kinked and vice versa.
摘要:
The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof as well as to pharmaceutical compositions comprising these compounds and to methods for their preparation. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要:
The present invention relates to compounds of formula I wherein X, A and R1 to R4 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要:
The present invention relates to compounds of formula I wherein A and R1 to R4 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要:
The present invention relates to compounds of formula I wherein R1 to R4 and G are as defined in the description and claims and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要:
The present invention refers to chemical compounds of formula (I) as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R5 have the significance given in claim 1. These compounds can be used for the preparation of medicaments.
摘要:
The present invention discloses compounds having the formula ##STR1## wherein one of R.sup.1 and R.sup.2 is --COR.sup.4, --CN, --CH.sub.2 R.sup.5, halogen, --CH.dbd.CHR.sup.6 or Q and the other is hydrogen or lower alkyl or both R.sup.1 and R.sup.2 together form a .gamma.-lactam ring,R.sup.3 is hydrogen, lower alkyl, aryl-alkyl, allyl or a residue which is cleavable in vivo,R.sup.4 is hydrogen, lower alkyl, lower alkoxy, benzyloxy, amino, lower alkylamino or lower alkyl-lower alkoxyamino,R.sup.5 is hydroxy, --OCONHR.sup.7, --OCONH.sub.2 or a five- or six-membered hetero-aromatic ring which contains N,S and/or O and which is linked via a nitrogen atom,R.sup.6 is --CN or CHO,R.sup.7 is --COCH.sub.2 Cl,Q is a five- or six-membered hetero-aromatic ring which contains N, S and/or O andn is 0, 1 or 2,and the pharmaceutically compatible salts thereof.These compounds are good .beta.-lactamase inhibitors. They can be used for the prevention or treatment of bacterial infections, optionally together with a .beta.-lactam antibiotic.
摘要:
A method and apparatus for installing an underground seal beneath a garbage dump in a strip-like manner. The earth is worked in strips under the garbage dump by the front end of a driving shield. The earth is transported to the rear end of the driving shield, and is compressed at the rear end. A strip-like layer of a waterproof material is inserted, under the protection of a cover of the driving shield. A supply tunnel pipe is constructed and subsequently dismantled, comprised of individual tunnel pipe sections, under the protection of the cover while the driving shield is moved forward. The dismantled tunnel pipe sections of the tunnel pipe are used to erect an additional tunnel pipe which is laterally displaced in a direction toward the next strip-like layer opposite the first one tunnel pipe behind the driving shield. By stabilizing the dismantled pipe sections they need not be dragged along or transported out of the remaining tunnel pipe.