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公开(公告)号：US20100323384A1
公开(公告)日：2010-12-23
申请号：US12446364
申请日：2007-10-29
CPC分类号： C12N5/0698 , C12N2502/094 , C12N2502/1323 , C12N2503/06 , C12N2533/70 , C12Q1/02 , G01N33/5073 , G01N2500/02
摘要： The present invention provides skin equivalents comprising human epidermal stem cells which are specifically labeled. The labeling is carried out with a marker capable of labeling slowly proliferating cells, e.g. iododeoxyuridine or PKH26. Particularly, the invention provides skin equivalents comprising labeled epidermal stem cells. The invention also provides corresponding uses and methods of using such cultures, e.g. in the fields of research and medical treatment of skin diseases.
摘要翻译： 本发明提供了包含特异性标记的人表皮干细胞的皮肤等同物。 标记用能够标记慢性增殖细胞的标记进行，例如， 碘脱氧尿苷或PKH26。 特别地，本发明提供了包含标记的表皮干细胞的皮肤等同物。 本发明还提供了相应的使用和使用这些培养物的方法。 在皮肤病研究和治疗领域。
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2.发明授权Scaffold-based organotypic culture for the long-term cultivation of human epidermal stem cells 有权基于脚手架的器官培养用于长期培养人类表皮干细胞公开(公告)号：US08871462B2
公开(公告)日：2014-10-28
申请号：US13636122
申请日：2011-03-22
CPC分类号： C12Q1/025 , C12N5/0698 , C12N2500/38 , C12N2501/01 , C12N2501/15 , C12N2501/39 , C12N2501/70 , C12N2502/094 , C12N2502/1323 , C12N2533/30 , C12N2533/56
摘要： The present invention relates to organotypic cultures of epidermal cells and the use thereof for the screening of pharmaceutical and cosmetic agents. Specifically, means for the improvement of the long-term stability of such cultures are disclosed. Thus, the present invention contemplates a skin equivalent comprising (a) a dermal equivalent comprising a matrix comprising nonwoven viscose fabric and fibroblasts and (b) keratinocytes. Moreover, the present invention contemplates a method for manufacturing the skin equivalent and a method for screening agents capable of influencing skin, such as a therapeutic or cosmetic agent.
摘要翻译： 本发明涉及表皮细胞的器官型培养物及其用于筛选药物和化妆品的用途。 具体地，公开了用于改善这些培养物的长期稳定性的手段。 因此，本发明设想皮肤等同物，其包含（a）皮肤当量，其包含包含非织造粘胶织物和成纤维细胞的基质和（b）角质形成细胞。 此外，本发明考虑了皮肤当量的制造方法以及能够影响皮肤的药剂如治疗剂或美容剂的筛选方法。
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3.发明申请SCAFFOLD-BASED ORGANOTYPIC CULTURE FOR THE LONG-TERM CULTIVATION OF HUMAN EPIDERMAL STEM CELLS 有权用于人类干细胞长期培养的基于SCAFFOLD的有机文化公开(公告)号：US20130078666A1
公开(公告)日：2013-03-28
申请号：US13636122
申请日：2011-03-22
IPC分类号： C12Q1/02
CPC分类号： C12Q1/025 , C12N5/0698 , C12N2500/38 , C12N2501/01 , C12N2501/15 , C12N2501/39 , C12N2501/70 , C12N2502/094 , C12N2502/1323 , C12N2533/30 , C12N2533/56
摘要： The present invention relates to organotypic cultures of epidermal cells and the use thereof for the screening of pharmaceutical and cosmetic agents. Specifically, means for the improvement of the long-term stability of such cultures are disclosed. Thus, the present invention contemplates a skin equivalent comprising (a) a dermal equivalent comprising a matrix comprising nonwoven viscose fabric and fibroblasts and (b) keratinocytes. Moreover, the present invention contemplates a method for manufacturing the skin equivalent and a method for screening agents capable of influencing skin, such as a therapeutic or cosmetic agent.
摘要翻译： 本发明涉及表皮细胞的器官型培养物及其用于筛选药物和化妆品的用途。 具体地，公开了用于改善这些培养物的长期稳定性的手段。 因此，本发明设想皮肤等同物，其包含（a）皮肤当量，其包含包含非织造粘胶织物和成纤维细胞的基质和（b）角质形成细胞。 此外，本发明考虑了皮肤当量的制造方法以及能够影响皮肤的药剂如治疗剂或美容剂的筛选方法。
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