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公开(公告)号：US07691886B2
公开(公告)日：2010-04-06
申请号：US10564185
申请日：2004-06-15
申请人： Hans-Peter Buchstaller , Dirk Finsinger , Matthias Wiesner , Lars Thore Burgdorf , Christiane Amendt , Matthias Grell , Christian Sirrenberg , Frank Zenke
发明人： Hans-Peter Buchstaller , Dirk Finsinger , Matthias Wiesner , Lars Thore Burgdorf , Christiane Amendt , Matthias Grell , Christian Sirrenberg , Frank Zenke
IPC分类号： C07D401/00 , A01N43/64
CPC分类号： C07D401/12
摘要： The present invention relates to benzimidazole derivatives of formula I, the use of the compounds of formula I as inhibitors of one or more kinases, the use of the compounds of formula I for the manufacture of a pharmaceutical compositions and methods of treatment, comprising administering said pharmaceutical compositions to patients.
摘要翻译： 本发明涉及式I的苯并咪唑衍生物，式I化合物作为一种或多种激酶抑制剂的用途，式I化合物在制备药物组合物和治疗方法中的应用，包括给予所述 药物组合物给患者。
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公开(公告)号：US08410143B2
公开(公告)日：2013-04-02
申请号：US12488191
申请日：2009-06-19
申请人： Hans-Peter Buchstaller , Matthias Wiesner , Oliver Schadt , Christiane Amendt , Frank Zenke , Christian Sirrenberg , Matthias Grell , Dirk Finsinger
发明人： Hans-Peter Buchstaller , Matthias Wiesner , Oliver Schadt , Christiane Amendt , Frank Zenke , Christian Sirrenberg , Matthias Grell , Dirk Finsinger
IPC分类号： A61K31/4412 , C07D213/68
CPC分类号： C07D213/68 , A61K31/44 , A61K31/4439 , A61K45/00 , C07D213/75 , C07D213/79 , C07D213/81 , C07D401/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention relates to methylene urea derivatives of formula (I), the use of the compounds of formula (I) as inhibitors of raf-kinase, the use of the compounds of formula (I) for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.
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公开(公告)号：US20060199844A1
公开(公告)日：2006-09-07
申请号：US10532574
申请日：2003-10-08
申请人： Hans-Peter Buchstaller , Matthias Wiesner , Oliver Schadt , Christiane Amendt , Frank Zenke , Christian Sirrenberg , Matthias Grell , Dirk Finsinger
发明人： Hans-Peter Buchstaller , Matthias Wiesner , Oliver Schadt , Christiane Amendt , Frank Zenke , Christian Sirrenberg , Matthias Grell , Dirk Finsinger
IPC分类号： A61K31/444 , C07D401/02 , A61K31/44 , C07D213/53
CPC分类号： C07D213/68 , A61K31/44 , A61K31/4439 , A61K45/00 , C07D213/75 , C07D213/79 , C07D213/81 , C07D401/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention relates to methylene urea derivatives of formula (I), the use of the compounds of formula (I) as inhibitors of raf-kinase, the use of the compounds of formula (I) for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.
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公开(公告)号：US20070149594A1
公开(公告)日：2007-06-28
申请号：US10579825
申请日：2004-10-26
申请人： Dirk Finsinger , Hans-Peter Buchstaller , Lars Burgdorf , Matthias Wiesner , Christiane Amendt , Matthias Grell , Christian Sirrenberg , Frank Zenke
发明人： Dirk Finsinger , Hans-Peter Buchstaller , Lars Burgdorf , Matthias Wiesner , Christiane Amendt , Matthias Grell , Christian Sirrenberg , Frank Zenke
IPC分类号： A61K31/401 , C07D207/30 , A61K31/40
CPC分类号： C07D207/337 , C07D401/12
摘要： Compounds of the formula (I), in which X, Y, Z and Ar have the meanings indicated in claim 1, are inhibitors of Raf kinase and can be employed, inter alia, for the treatment of tumours
摘要翻译： 其中X，Y，Z和Ar具有权利要求1所述含义的式（I）化合物是Raf激酶的抑制剂，并且可以用于治疗肿瘤
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公开(公告)号：US20090298885A1
公开(公告)日：2009-12-03
申请号：US12488191
申请日：2009-06-19
申请人： Hans-Peter Buchstaller , Matthias Wiesner , Oliver Schadt , Christiane Amendt , Frank Zenke , Christian Sirrenberg , Matthias Grell , Dirk Finsinger
发明人： Hans-Peter Buchstaller , Matthias Wiesner , Oliver Schadt , Christiane Amendt , Frank Zenke , Christian Sirrenberg , Matthias Grell , Dirk Finsinger
IPC分类号： A61K31/4439 , A61K31/4412 , C07D213/78 , C07D413/12 , C07D417/00
CPC分类号： C07D213/68 , A61K31/44 , A61K31/4439 , A61K45/00 , C07D213/75 , C07D213/79 , C07D213/81 , C07D401/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention relates to methylene urea derivatives of formula (I), the use of the compounds of formula (I) as inhibitors of raf-kinase, the use of the compounds of formula (I) for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.
摘要翻译： 本发明涉及式（I）的亚甲基脲衍生物，式（I）化合物作为raf-激酶抑制剂的用途，式（I）化合物用于制备药物组合物和 包括将所述药物组合物施用于患者。
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公开(公告)号：US20090253688A1
公开(公告)日：2009-10-08
申请号：US10590664
申请日：2005-02-14
申请人： Hans-Peter Buchstaller , Dirk Finsinger , Frank Stieber , Matthias Wiesner , Christiane Amendt , Christian Sirrenberg , Frank Zenke , Matthias Grell
发明人： Hans-Peter Buchstaller , Dirk Finsinger , Frank Stieber , Matthias Wiesner , Christiane Amendt , Christian Sirrenberg , Frank Zenke , Matthias Grell
IPC分类号： A61K31/541 , C07D213/68 , A61K31/4409 , A61K31/5377 , C07D413/12 , C07D417/12 , A61P35/00
CPC分类号： C07D213/68 , C07D213/81 , C07D401/12
摘要： The present invention relates to semicarbazide derivatives of formula I, the use of the compounds of formula I as inhibitors of one or more kinases, the use of the compounds of formula I for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.
摘要翻译： 本发明涉及式I的氨基脲衍生物，式I化合物作为一种或多种激酶的抑制剂的用途，式I化合物在制备药物组合物中的用途及其治疗方法，其包括施用 所述药物组合物对患者而言。
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公开(公告)号：US07598274B2
公开(公告)日：2009-10-06
申请号：US10579825
申请日：2004-10-26
申请人： Dirk Finsinger , Hans-Peter Buchstaller , Lars Burgdorf , Matthias Wiesner , Christiane Amendt , Matthias Grell , Christian Sirrenberg , Frank Zenke
发明人： Dirk Finsinger , Hans-Peter Buchstaller , Lars Burgdorf , Matthias Wiesner , Christiane Amendt , Matthias Grell , Christian Sirrenberg , Frank Zenke
IPC分类号： A61K31/4439 , C07D401/02
CPC分类号： C07D207/337 , C07D401/12
摘要： Compounds of the formula (I), in which X, Y, Z and Ar have the meanings indicated in claim 1, are inhibitors of Raf kinase and can be employed, inter alia, for the treatment of tumours
摘要翻译： 其中X，Y，Z和Ar具有权利要求1所述含义的式（I）化合物是Raf激酶的抑制剂，并且可以用于治疗肿瘤
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公开(公告)号：US07589112B2
公开(公告)日：2009-09-15
申请号：US10532574
申请日：2003-10-08
申请人： Hans-Peter Buchstaller , Matthias Wiesner , Oliver Schadt , Christiane Amendt , Frank Zenke , Christian Sirrenberg , Matthias Grell , Dirk Finsinger
发明人： Hans-Peter Buchstaller , Matthias Wiesner , Oliver Schadt , Christiane Amendt , Frank Zenke , Christian Sirrenberg , Matthias Grell , Dirk Finsinger
IPC分类号： A61K31/4412 , C07D213/68
CPC分类号： C07D213/68 , A61K31/44 , A61K31/4439 , A61K45/00 , C07D213/75 , C07D213/79 , C07D213/81 , C07D401/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention relates to methylene urea derivatives of formula (I), the use of the compounds of formula (I) as inhibitors of raf-kinase, the use of the compounds of formula (I) for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.
摘要翻译： 本发明涉及式（I）的亚甲基脲衍生物，式（I）化合物作为raf-激酶抑制剂的用途，式（I）化合物用于制备药物组合物和 包括将所述药物组合物施用于患者。
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公开(公告)号：US20070093529A1
公开(公告)日：2007-04-26
申请号：US10582496
申请日：2004-11-11
申请人： Dirk Finsinger , Hans-Peter Buchstaller , Lars Burgdorf , Christiane Amendt , Matthias Grell , Christian Sirrenberg , Frank Zenke
发明人： Dirk Finsinger , Hans-Peter Buchstaller , Lars Burgdorf , Christiane Amendt , Matthias Grell , Christian Sirrenberg , Frank Zenke
IPC分类号： C07D403/02 , A61K31/4439 , A61K31/4412
CPC分类号： C07D213/81 , C04B35/632 , C07C243/38 , C07D207/327 , C07D213/54 , C07D213/66 , C07D213/68 , C07D243/38 , C07D249/18 , C07D317/68 , C07D401/12 , C07D413/12
摘要： The present invention relates to diacylhydrazine derivatives of formula I, the use of the compounds of formula I as inhibitors of raf-kinase, the use of the compounds of formula I for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.
摘要翻译： 本发明涉及式I的二酰肼衍生物，式I化合物作为raf-激酶抑制剂的用途，式I化合物在制备药物组合物中的用途及其治疗方法，包括给予所述 药物组合物给患者。
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公开(公告)号：US20090163556A1
公开(公告)日：2009-06-25
申请号：US12273040
申请日：2008-11-18
申请人： Hans-Peter Buchstaller , Matthias Wiesner , Oliver Schadt , Christiane Amendt , Frank Zenke , Christian Sirrenberg , Matthias Grell
发明人： Hans-Peter Buchstaller , Matthias Wiesner , Oliver Schadt , Christiane Amendt , Frank Zenke , Christian Sirrenberg , Matthias Grell
IPC分类号： A61K31/4406 , A61K31/4402 , C07D213/63 , A61P35/00
CPC分类号： C07D413/12 , C07D213/65 , C07D213/68
摘要： The present invention relates to glycinamide derivatives of formula I, A-D-B (I), wherein A, D, and B are as herein defined, as well as the use of the compounds of formula I as inhibitors of raf-kinase, the use of the compounds of formula I for the manufacture of a pharmaceutical composition, and a method of treatment comprising administering said pharmaceutical composition to a patient.
摘要翻译： 本发明涉及式I的甘氨酰胺衍生物，<？in-line-formula description =“In-line Formulas”end =“lead”→> ADB（I），<？in-line-formula description =“In- 其中A，D和B如本文所定义，以及式I化合物作为raf-激酶抑制剂的用途，式I化合物用于 药物组合物的制造，以及包括向患者施用所述药物组合物的治疗方法。
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