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公开(公告)号:US07928217B2
公开(公告)日:2011-04-19
申请号:US11139089
申请日:2005-05-27
申请人: Hans-Peter Vornlocher , Ingo Roehl , Philipp Hadwiger , Tracy Stage Zimmermann , Muthiah Manoharan , Kallanthottathil G. Rajeev , Akin Akinc
发明人: Hans-Peter Vornlocher , Ingo Roehl , Philipp Hadwiger , Tracy Stage Zimmermann , Muthiah Manoharan , Kallanthottathil G. Rajeev , Akin Akinc
CPC分类号: C07H21/02 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2310/315 , C12N2310/318 , C12N2310/321 , C12N2310/322 , C12N2310/323 , C12N2310/3231 , C12N2310/53 , C12N2320/51 , C12N2310/3521 , C12N2310/3525 , C12N2310/3527
摘要: This invention relates to modified double-stranded oligoribonucleic acid (dsRNA) having improved stability in cells and biological fluids, and methods of making and identifying dsRNA having improved stability, and of using the dsRNA to inhibit the expression or function of a target gene.
摘要翻译: 本发明涉及在细胞和生物流体中具有改善的稳定性的修饰的双链寡核糖核酸(dsRNA),以及制备和鉴定具有改善的稳定性的dsRNA的方法,以及使用dsRNA抑制靶基因的表达或功能。
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公开(公告)号:US08334373B2
公开(公告)日:2012-12-18
申请号:US13038672
申请日:2011-03-02
申请人: Hans-Peter Vornlocher , Ingo Roehl , Philipp Hadwiger , Tracy Stage Zimmermann , Muthiah Manoharan , Kallanthottathil G. Rajeev , Akin Akinc
发明人: Hans-Peter Vornlocher , Ingo Roehl , Philipp Hadwiger , Tracy Stage Zimmermann , Muthiah Manoharan , Kallanthottathil G. Rajeev , Akin Akinc
CPC分类号: C07H21/02 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2310/315 , C12N2310/318 , C12N2310/321 , C12N2310/322 , C12N2310/323 , C12N2310/3231 , C12N2310/53 , C12N2320/51 , C12N2310/3521 , C12N2310/3525 , C12N2310/3527
摘要: This invention relates to modified double-stranded oligoribonucleic acid (dsRNA) having improved stability in cells and biological fluids, and methods of making and identifying dsRNA having improved stability, and of using the dsRNA to inhibit the expression or function of a target gene.
摘要翻译: 本发明涉及在细胞和生物流体中具有改善的稳定性的修饰的双链寡核糖核酸(dsRNA),以及制备和鉴定具有改善的稳定性的dsRNA的方法,以及使用dsRNA抑制靶基因的表达或功能。
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公开(公告)号:US08993746B2
公开(公告)日:2015-03-31
申请号:US13431376
申请日:2012-03-27
申请人: Hans-Peter Vornlocher , Ingo Roehl , Philipp Hadwiger , Tracy Stage Zimmermann , Muthiah Manoharan , Kallanthottathil G. Rajeev , Akin Akinc
发明人: Hans-Peter Vornlocher , Ingo Roehl , Philipp Hadwiger , Tracy Stage Zimmermann , Muthiah Manoharan , Kallanthottathil G. Rajeev , Akin Akinc
IPC分类号: C07H21/00 , C07H21/02 , C12N15/11 , C12N15/113
CPC分类号: C07H21/02 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2310/315 , C12N2310/318 , C12N2310/321 , C12N2310/322 , C12N2310/323 , C12N2310/3231 , C12N2310/53 , C12N2320/51 , C12N2310/3521 , C12N2310/3525 , C12N2310/3527
摘要: This invention relates to modified double-stranded oligoribonucleic acid (dsRNA) having improved stability in cells and biological fluids, and methods of making and identifying dsRNA having improved stability, and of using the dsRNA to inhibit the expression or function of a target gene.
摘要翻译: 本发明涉及在细胞和生物流体中具有改善的稳定性的修饰的双链寡核糖核酸(dsRNA),以及制备和鉴定具有改善的稳定性的dsRNA的方法,以及使用dsRNA抑制靶基因的表达或功能。
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公开(公告)号:US20060094678A1
公开(公告)日:2006-05-04
申请号:US11139089
申请日:2005-05-27
申请人: Hans-Peter Vornlocher , Ingo Roehl , Philipp Hadwiger , Tracy Zimmermann , Muthiah Manoharan , Kallanthottathil Rajeev , Akin Akinc
发明人: Hans-Peter Vornlocher , Ingo Roehl , Philipp Hadwiger , Tracy Zimmermann , Muthiah Manoharan , Kallanthottathil Rajeev , Akin Akinc
CPC分类号: C07H21/02 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2310/315 , C12N2310/318 , C12N2310/321 , C12N2310/322 , C12N2310/323 , C12N2310/3231 , C12N2310/53 , C12N2320/51 , C12N2310/3521 , C12N2310/3525 , C12N2310/3527
摘要: This invention relates to modified double-stranded oligoribonucleic acid (dsRNA) having improved stability in cells and biological fluids, and methods of making and identifying dsRNA having improved stability, and of using the dsRNA to inhibit the expression or function of a target gene.
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公开(公告)号:US20130018085A1
公开(公告)日:2013-01-17
申请号:US13620212
申请日:2012-09-14
申请人: Antonin de Fougerolles , Maria Frank-Kamenetsky , Muthiah Manoharan , Kallanthottathil G. Rajeev , Philipp Hadwiger
发明人: Antonin de Fougerolles , Maria Frank-Kamenetsky , Muthiah Manoharan , Kallanthottathil G. Rajeev , Philipp Hadwiger
IPC分类号: A61K31/713 , A61P35/00 , A61P27/02 , C12N5/071 , C07H21/02
CPC分类号: C12N15/1136 , A61K9/0019 , A61K31/7088 , A61K31/712 , A61K31/713 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/549 , A61K47/551 , A61K47/60 , A61K48/00 , C07K14/475 , C12N2310/14 , C12N2310/3515 , C12N2310/533 , C12N2320/30 , C12N2320/32
摘要: The features of the present invention relate to compounds, compositions and methods useful for modulating the expression of vascular endothelial growth factor (VEGF), such as by the mechanism of RNA interference (RNAi). The compounds and compositions include iRNA agents that can be unmodified or chemically-modified.
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公开(公告)号:US07947659B2
公开(公告)日:2011-05-24
申请号:US11078073
申请日:2005-03-11
申请人: Antonin de Fougerolles , Maria Frank-Kamenetsky , Muthiah Manoharan , Kallanthottathil G. Rajeev , Philipp Hadwiger
发明人: Antonin de Fougerolles , Maria Frank-Kamenetsky , Muthiah Manoharan , Kallanthottathil G. Rajeev , Philipp Hadwiger
CPC分类号: C12N15/1136 , A61K9/0019 , A61K31/7088 , A61K31/712 , A61K31/713 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/549 , A61K47/551 , A61K47/60 , A61K48/00 , C07K14/475 , C12N2310/14 , C12N2310/3515 , C12N2310/533 , C12N2320/30 , C12N2320/32
摘要: The features of the present invention relate to compounds, compositions and methods useful for modulating the expression of vascular endothelial growth factor (VEGF), such as by the mechanism of RNA interference (RNAi). The compounds and compositions include iRNA agents that can be unmodified or chemically-modified.
摘要翻译: 本发明的特征涉及用于调节血管内皮生长因子(VEGF)表达的化合物,组合物和方法,例如通过RNA干扰(RNAi)机制。 化合物和组合物包括可以未修饰或化学修饰的iRNA试剂。
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公开(公告)号:US20110224282A1
公开(公告)日:2011-09-15
申请号:US13043228
申请日:2011-03-08
申请人: Antonin De Fougerolles , Maria Frank-Kamenetsky , Muthiah Manoharan , Kallanthottathil G. Rajeev , Philipp Hadwiger
发明人: Antonin De Fougerolles , Maria Frank-Kamenetsky , Muthiah Manoharan , Kallanthottathil G. Rajeev , Philipp Hadwiger
IPC分类号: A61K31/713 , C07H21/02 , A61P27/02 , C12N5/071 , C12N5/09
CPC分类号: C12N15/1136 , A61K9/0019 , A61K31/7088 , A61K31/712 , A61K31/713 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/549 , A61K47/551 , A61K47/60 , A61K48/00 , C07K14/475 , C12N2310/14 , C12N2310/3515 , C12N2310/533 , C12N2320/30 , C12N2320/32
摘要: The features of the present invention relate to compounds, compositions and methods useful for modulating the expression of vascular endothelial growth factor (VEGF), such as by the mechanism of RNA interference (RNAi). The compounds and compositions include iRNA agents that can be unmodified or chemically-modified.
摘要翻译: 本发明的特征涉及用于调节血管内皮生长因子(VEGF)表达的化合物,组合物和方法,例如通过RNA干扰(RNAi)机制。 化合物和组合物包括可以未修饰或化学修饰的iRNA试剂。
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公开(公告)号:US20100292305A1
公开(公告)日:2010-11-18
申请号:US12753650
申请日:2010-04-02
申请人: Akin Akinc , Antonin de Fougerolles , Hans-Peter Vornlocher , Philipp Hadwiger , Birgit Bramlage
发明人: Akin Akinc , Antonin de Fougerolles , Hans-Peter Vornlocher , Philipp Hadwiger , Birgit Bramlage
IPC分类号: A61K31/7052 , C07H21/02 , A61P27/02
CPC分类号: C12N15/113 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3521
摘要: The features of the present invention relate to compounds, compositions and methods useful for modulating the expression of HIF-1α, such as by the mechanism of RNA interference (RNAi). The compounds and compositions include iRNA agents that can be unmodified or chemically-modified.
摘要翻译: 本发明的特征涉及用于调节HIF-1α表达的化合物,组合物和方法,例如通过RNA干扰(RNAi)机制。 化合物和组合物包括可以未修饰或化学修饰的iRNA试剂。
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公开(公告)号:US20070155686A1
公开(公告)日:2007-07-05
申请号:US11477028
申请日:2006-06-27
CPC分类号: C12N15/113 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3521
摘要: The features of the present invention relate to compounds, compositions and methods useful for modulating the expression of HIF-1α, such as by the mechanism of RNA interference (RNAi). The compounds and compositions include iRNA agents that can be unmodified or chemically-modified.
摘要翻译: 本发明的特征涉及用于调节HIF-1α表达的化合物,组合物和方法,例如通过RNA干扰(RNAi)机制。 化合物和组合物包括可以未修饰或化学修饰的iRNA试剂。
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公开(公告)号:US08293719B2
公开(公告)日:2012-10-23
申请号:US13043228
申请日:2011-03-08
申请人: Antonin De Fougerolles , Maria Frank-Kamenetsky , Muthiah Manoharan , Kallanthottathil G. Rajeev , Philipp Hadwiger
发明人: Antonin De Fougerolles , Maria Frank-Kamenetsky , Muthiah Manoharan , Kallanthottathil G. Rajeev , Philipp Hadwiger
CPC分类号: C12N15/1136 , A61K9/0019 , A61K31/7088 , A61K31/712 , A61K31/713 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/549 , A61K47/551 , A61K47/60 , A61K48/00 , C07K14/475 , C12N2310/14 , C12N2310/3515 , C12N2310/533 , C12N2320/30 , C12N2320/32
摘要: The features of the present invention relate to compounds, compositions and methods useful for modulating the expression of vascular endothelial growth factor (VEGF), such as by the mechanism of RNA interference (RNAi). The compounds and compositions include iRNA agents that can be unmodified or chemically-modified.
摘要翻译: 本发明的特征涉及用于调节血管内皮生长因子(VEGF)表达的化合物,组合物和方法,例如通过RNA干扰(RNAi)机制。 所述化合物和组合物包括可以未修饰或化学修饰的iRNA试剂。
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