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    Process for the preparation of tripeptides
    1.
    发明授权
    Process for the preparation of tripeptides 失效
    制备三肽的方法

    公开(公告)号：US5191065A

    公开(公告)日：1993-03-02

    申请号：US728028

    申请日：1991-07-08

    申请人： Hans-Wolfram Flemming ,  Manfred Rukwied ,  Manfred Schmidt

    发明人： Hans-Wolfram Flemming ,  Manfred Rukwied ,  Manfred Schmidt

    IPC分类号： C07K1/08 ,  C07K5/097

    CPC分类号： C07K5/0821 ,  C07K1/082 ,  Y02P20/55

    摘要： A process for the preparation of tripeptides of the general formula IU-A-B-C-OH Iin which U denotes hydrogen or a urethane protective group and A, B and C denote amino acids, by reaction of a compound of the general formula IIU'-B-OH IIin which U' is a urethane protective group which can be eliminated by hydrogenolysis, with a compound of the general formula IIIH-C-OR IIIin which R denotes alkyl, by the PPA method, elimination of U', and reacting the resulting compound of the formula IVH-B-C-OR IVwith a compound of the formula VU-A-OH Vin the presence of propylphosphonic anhydride, and finally eliminating R enzymatically.

    摘要翻译： 制备通式I UABC-OH I的三肽的方法，其中U表示氢或氨基甲酸酯保护基，A，B和C表示氨基酸，通过通式II U'-B的化合物 -OH II，其中U'是可以通过氢解消除的氨基甲酸酯保护基，其中通式III HC-OR III的化合物，其中R表示烷基，通过PPA方法，消除U'，并使 得到式IV HBC-OR IV化合物与式V UA-OH V化合物在丙基膦酸酐存在下反应，最后酶消除R。

    Process for the preparation of thiophene derivatives and also new dihydrothiophene 1-oxides
    2.
    发明授权
    Process for the preparation of thiophene derivatives and also new dihydrothiophene 1-oxides 失效
    制备噻吩衍生物的方法以及新的二氢噻吩1-氧化物

    公开(公告)号：US5166346A

    公开(公告)日：1992-11-24

    申请号：US630434

    申请日：1990-12-20

    申请人： Robert Rippel ,  Hans-Wolfram Flemming ,  Manfred Rukwied

    发明人： Robert Rippel ,  Hans-Wolfram Flemming ,  Manfred Rukwied

    IPC分类号： C07D333/38 ,  C07D333/48

    CPC分类号： C07D333/48 ,  C07D333/38

    摘要： Process for the preparation of thiophene derivatives and also new dihydrothiophene 1-oxides.Thiophene derivatives having an--optionally substituted--amino group on the thiophene ring are prepared by dehydrogenating dihydrothiophenes, substituted in a manner identical to that of the desired thiophene derivatives, by means of H.sub.2 O.sub.2, the dihydrothiophenes being reacted with H.sub.2 O.sub.2 in a first reaction stage in a neutral medium to give the corresponding sulfoxides, which are then rearranged into the thiophene derivatives by means of acid in the second reaction stage.The dihydrothiophene 1-oxides formed as intermediates in this reaction are new compounds. Like the thiophene derivatives formed from them by rearrangement with acid, they are intermediates, mainly in the sector of plant protection agents and pharmaceuticals.

    摘要翻译： 制备噻吩衍生物的方法以及新的二氢噻吩1-氧化物。 在噻吩环上具有任选取代的氨基的噻吩衍生物通过用H 2 O 2脱氢二氢噻吩，以与所需噻吩衍生物相同的方式进行脱氢，二氢噻吩与H 2 O 2反应，在第一反应阶段 中性介质，得到相应的亚砜，然后在第二反应阶段通过酸将其重排成噻吩衍生物。 在该反应中作为中间体形成的二氢噻吩1-氧化物是新的化合物。 像它们通过与酸重排形成的噻吩衍生物一样，它们是中间体，主要在植物保护剂和药物领域。

    Process for obtaining 3,7-dialkylxanthines from 3-alkyl-xanthines
    9.
    发明授权
    Process for obtaining 3,7-dialkylxanthines from 3-alkyl-xanthines 失效
    从3-烷基 - 黄嘌呤获得3,7-二烷基黄嘌呤的方法

    公开(公告)号：US5475107A

    公开(公告)日：1995-12-12

    申请号：US149488

    申请日：1993-11-09

    申请人： Gerhard Korb ,  Hans-Wolfram Flemming

    发明人： Gerhard Korb ,  Hans-Wolfram Flemming

    IPC分类号： A61K31/52 ,  C07D473/06 ,  C07D473/10

    CPC分类号： C07D473/06 ,  C07D473/10

    摘要： Process for obtaining 3,7-dialkylxanthines from 3-alkyl-xanthines3,7-Dialkylxanthines are obtained from the corresponding 3-alkylxanthines using an alkylating agent in the presence of quaternary ammonium and/or phosphonium compounds and, where appropriate, of additional polyethers in a two-phase mixture.

    摘要翻译： 从3-烷基 - 黄嘌呤获得3,7-二烷基黄嘌呤的方法3,7-二烷基黄嘌呤使用烷基化剂在季铵和/或鏻化合物的存在下，并且在适当的情况下由相应的3-烷基黄嘌呤获得，另外的聚醚 在两相混合物中。