公开(公告)号：US07937147B2

公开(公告)日：2011-05-03

申请号：US11680322

申请日：2007-02-28

申请人： Haris Sih ,  Mark Schwartz ,  Anthony V. Caparso

发明人： Haris Sih ,  Mark Schwartz ,  Anthony V. Caparso

IPC分类号： A61N1/36

CPC分类号： A61N1/0556 ,  A61N1/05 ,  A61N1/0587 ,  A61N1/36114 ,  A61N1/3621 ,  A61N1/3624 ,  A61N1/395 ,  A61N1/3962

摘要： The invention relates to methods and devices for treating and/or preventing atrial fibrillation. In an embodiment, the invention includes a method of treating and/or preventing atrial fibrillation including applying an oscillating electrical stimulus to a tissue of a patient, the oscillating electrical stimulus sufficient to block transmission of electrical signals through the tissue. In an embodiment, the invention includes an implantable medical device including a stimulator configured to generate an oscillating electrical stimulus at a frequency and amplitude sufficient to block transmission of electrical signals through a tissue, a stimulation electrode in communication with the stimulator, the stimulation electrode configured to deliver the oscillating electrical stimulus to the tissue, and control circuitry in communication with the stimulator, the control circuitry configured to selectively deliver the oscillating electrical stimulus to treat and/or prevent atrial fibrillation. Other embodiments are also described herein.

摘要翻译： 本发明涉及用于治疗和/或预防房颤的方法和装置。 在一个实施方案中，本发明包括治疗和/或预防房颤的方法，包括将振荡电刺激施加到患者的组织，所述振荡电刺激足以阻止电信号通过组织传播。 在一个实施例中，本发明包括可植入医疗装置，其包括刺激器，所述刺激器被配置为产生振荡电刺激，其频率和幅度足以阻止通过组织的电信号的传输，与所述刺激器通信的刺激电极， 将振荡电刺激递送到组织，以及与刺激器通信的控制电路，所述控制电路被配置为选择性地递送振荡电刺激以治疗和/或预防房颤。 本文还描述了其它实施例。

公开(公告)号：US20080208271A1

公开(公告)日：2008-08-28

申请号：US11680322

申请日：2007-02-28

申请人： Haris Sih ,  Mark Schwartz ,  Anthony V. Caparso

发明人： Haris Sih ,  Mark Schwartz ,  Anthony V. Caparso

IPC分类号： A61N1/06

CPC分类号： A61N1/0556 ,  A61N1/05 ,  A61N1/0587 ,  A61N1/36114 ,  A61N1/3621 ,  A61N1/3624 ,  A61N1/395 ,  A61N1/3962

摘要： The invention relates to methods and devices for treating and/or preventing atrial fibrillation. In an embodiment, the invention includes a method of treating and/or preventing atrial fibrillation including applying an oscillating electrical stimulus to a tissue of a patient, the oscillating electrical stimulus sufficient to block transmission of electrical signals through the tissue. In an embodiment, the invention includes an implantable medical device including a stimulator configured to generate an oscillating electrical stimulus at a frequency and amplitude sufficient to block transmission of electrical signals through a tissue, a stimulation electrode in communication with the stimulator, the stimulation electrode configured to deliver the oscillating electrical stimulus to the tissue, and control circuitry in communication with the stimulator, the control circuitry configured to selectively deliver the oscillating electrical stimulus to treat and/or prevent atrial fibrillation. Other embodiments are also described herein.

摘要翻译： 本发明涉及用于治疗和/或预防房颤的方法和装置。 在一个实施方案中，本发明包括治疗和/或预防房颤的方法，包括将振荡电刺激施加到患者的组织，所述振荡电刺激足以阻止电信号通过组织传播。 在一个实施例中，本发明包括可植入医疗装置，其包括刺激器，所述刺激器被配置为产生振荡电刺激，其频率和幅度足以阻止通过组织的电信号的传输，与所述刺激器通信的刺激电极， 将振荡电刺激递送到组织，以及与刺激器通信的控制电路，所述控制电路被配置为选择性地递送振荡电刺激以治疗和/或预防房颤。 本文还描述了其它实施例。

公开(公告)号：US08406866B2

公开(公告)日：2013-03-26

申请号：US12650060

申请日：2009-12-30

申请人： Don Curtis Deno ,  Stephan P. Miller ,  Lewis C Hill ,  Yuriy Malinin ,  Haris Sih

发明人： Don Curtis Deno ,  Stephan P. Miller ,  Lewis C Hill ,  Yuriy Malinin ,  Haris Sih

IPC分类号： A61B5/05

CPC分类号： A61B18/00 ,  A61B5/053 ,  A61B5/6885 ,  A61B5/6886 ,  A61B18/1233 ,  A61B18/14 ,  A61B18/1492 ,  A61B2018/00178 ,  A61B2018/00642 ,  A61B2018/00773 ,  A61B2018/00875 ,  A61B2090/065

摘要： A system and method for assessing a degree of coupling between an electrode and tissue in a body is provided. Values for first and second components of a complex impedance (e.g., resistance and reactance or impedance magnitude and phase angle) between the electrode and the tissue are obtained. These values are used together with a standardization value indicative of a deviation from a reference standard by a parameter associated with at least one of the body, the electrode and another component of the system to calculate a coupling index that is indicative of a degree of coupling between the electrode and the tissue. The coupling index may be displayed to a clinician in a variety of ways to indicate the degree of coupling to the clinician. The system and method find particular application in ablation of tissue by permitting a clinician to create lesions in the tissue more effectively and safely.

公开(公告)号：US20070036771A1

公开(公告)日：2007-02-15

申请号：US11277552

申请日：2006-03-27

申请人： Darrell Wagner ,  Haris Sih ,  Jihong Qu ,  Jeffrey Ross ,  Steven Girouard ,  Ronald Heil

发明人： Darrell Wagner ,  Haris Sih ,  Jihong Qu ,  Jeffrey Ross ,  Steven Girouard ,  Ronald Heil

IPC分类号： A61K48/00 ,  G06F19/00 ,  A61N1/00

CPC分类号： A61K48/0008 ,  A61K48/0083 ,  A61N1/05

摘要： A system and device are provided which include a gene regulatory system controlling expression of one or more expression cassettes present in or released by the device, by emitting one or more stimulations. An expression cassette includes a regulatable transcription control element that is responsive to the emitted stimulations linked to an open reading frame of interest. The system optionally includes a sensor to sense a parameter indicative of a need, a telemetry module to receive an external command, or a programmable device, for regulating gene expression of the open reading frame.

摘要翻译： 提供了一种系统和装置，其包括通过发射一种或多种刺激来控制存在于或释放的装置中的一种或多种表达盒的表达的基因调控系统。 表达盒包括可调节的转录控制元件，其响应于与感兴趣的开放阅读框架相关联的发射刺激。 该系统可选地包括用于感测指示需要的参数的传感器，用于接收外部命令的遥测模块或用于调节开放阅读框的基因表达的可编程设备。

公开(公告)号：US20080076836A1

公开(公告)日：2008-03-27

申请号：US11843573

申请日：2007-08-22

申请人： Darrell Wagner ,  Haris Sih ,  Steven Girouard

发明人： Darrell Wagner ,  Haris Sih ,  Steven Girouard

IPC分类号： A61K31/00 ,  A61P43/00 ,  C12P1/00 ,  C12Q1/02

CPC分类号： G01N33/5017 ,  G01N2500/10

摘要： A biologic agent preparation system is provided for producing one or more biologic agents in vitro including pro-growth factors and/or pro-survival factors from cells. The one or more biologic agents are produced in response to exposure of mammalian cells to light. A biologic agent delivery system is also provided that delivers the pro-growth factors and/or pro-survival factors to an injured tissue region, or delivers cells treated with the pro-growth factors and/or pro-survival factors to the injured tissue region.

摘要翻译： 提供生物制剂制备系统用于在体外制备一种或多种生物制剂，包括来自细胞的促生长因子和/或促生存因子。 响应于哺乳动物细胞暴露于光而产生一种或多种生物制剂。 还提供生物剂递送系统，其将促生长因子和/或促生存因子递送至损伤的组织区域，或将用促生长因子和/或促生存因子处理的细胞递送至受损组织区域 。

公开(公告)号：US20070036770A1

公开(公告)日：2007-02-15

申请号：US11272432

申请日：2005-11-10

申请人： Darrell Wagner ,  Haris Sih ,  Jihong Ou ,  Jeffrey Ross ,  Steven Girouard ,  Ronald Heil

发明人： Darrell Wagner ,  Haris Sih ,  Jihong Ou ,  Jeffrey Ross ,  Steven Girouard ,  Ronald Heil

IPC分类号： A61K48/00 ,  G06F19/00 ,  C12N15/86

CPC分类号： A61K48/0008 ,  A61K48/0083 ,  A61N1/05

摘要： A system and device are provided which include a gene regulatory system controlling expression of one or more expression cassettes present in or released by the device, by emitting one or more stimulations. An expression cassette includes a regulatable transcription control element that is responsive to the emitted stimulations linked to an open reading frame of interest. The system optionally includes a sensor to sense a parameter indicative of a need, a telemetry module to receive an external command, or a programmable device, for regulating gene expression of the open reading frame.

摘要翻译： 提供了一种系统和装置，其包括通过发射一种或多种刺激来控制存在于或释放的装置中的一种或多种表达盒的表达的基因调控系统。 表达盒包括可调节的转录控制元件，其响应于与感兴趣的开放阅读框架相关联的发射刺激。 该系统可选地包括用于感测指示需要的参数的传感器，用于接收外部命令的遥测模块或用于调节开放阅读框的基因表达的可编程设备。

公开(公告)号：US20070150005A1

公开(公告)日：2007-06-28

申请号：US11318263

申请日：2005-12-23

申请人： Haris Sih ,  Tamara Baynham ,  Darrell Wagner

发明人： Haris Sih ,  Tamara Baynham ,  Darrell Wagner

IPC分类号： A61N1/36

CPC分类号： A61N1/3627

摘要： A stimulation system delivers stimulation to protect an ischemic region of a body from tissue damage caused by ischemia. The stimulation is delivered to one or more stimulation sites remote from the ischemic region to elicit a physiological effect that protects the ischemic region from the tissue damage caused by ischemia. In one embodiment, the stimulation system delivers cardioprotective stimulation to one or more stimulation sites remote from the heart to protect the heart from injuries associated with cardiac ischemic events. In another embodiment, the stimulation system delivers remote conditioning stimulation to one or more stimulation sites in or on the heart to protect a non-cardiac region from injuries associated with non-cardiac ischemic events.

摘要翻译： 刺激系统提供刺激以保护身体的缺血区域免于由局部缺血引起的组织损伤。 刺激被递送到远离缺血区域的一个或多个刺激部位，以产生保护缺血区域免受缺血引起的组织损伤的生理作用。 在一个实施例中，刺激系统将心脏保护刺激递送到远离心脏的一个或多个刺激部位，以保护心脏免于与心脏缺血事件相关的损伤。 在另一个实施例中，刺激系统将远程调节刺激递送到心脏中或心脏上的一个或多个刺激部位，以保护非心脏区域免于与非心脏缺血事件相关的损伤。

公开(公告)号：US20070106202A1

公开(公告)日：2007-05-10

申请号：US11267654

申请日：2005-11-04

申请人： Rodyney Salo ,  Joseph Pastore ,  Haris Sih ,  Jihong Qu

发明人： Rodyney Salo ,  Joseph Pastore ,  Haris Sih ,  Jihong Qu

IPC分类号： A61N1/30

CPC分类号： A61N1/36557 ,  A61K48/005 ,  A61K48/0083 ,  A61M5/14276 ,  A61M2205/054 ,  A61N1/0568 ,  A61N1/0575 ,  A61N1/3605 ,  A61N1/3628 ,  A61N1/3706

摘要： A biologic agent delivery system provides for delivery of a biologic agent to a stimulation site to which electrical stimulation pulses are to be delivered from an electrical stimulation device. Examples of the electrical stimulation device include cardiac pacemakers and neural stimulators. The biologic agent modifies tissue property to lower the stimulation threshold of the stimulation site. The genetic modification of the tissue property improves efficacy and/or energy efficiency of an electrical stimulation therapy.

摘要翻译： 生物剂递送系统提供将生物剂递送到刺激部位，电刺激脉冲从电刺激装置输送到刺激部位。 电刺激装置的实例包括心脏起搏器和神经刺激器。 生物制剂改变组织特性以降低刺激部位的刺激阈值。 组织性质的遗传修饰改善电刺激疗法的功效和/或能量效率。

公开(公告)号：US20060095082A1

公开(公告)日：2006-05-04

申请号：US11300674

申请日：2005-12-14

申请人： Haris Sih ,  Scott Meyer ,  Paul Haefner

发明人： Haris Sih ,  Scott Meyer ,  Paul Haefner

IPC分类号： A61N1/39

CPC分类号： A61N1/3962

摘要： The present invention provides methods and systems for tachyarrhythmia therapy involving pacing the heart to prior to the application of a cardioversion/defibrillation shock. One or more pace pulses are delivered to the arrhythmic chamber or chambers. The pace pulses may be delivered to the heart at an adaptable rate selected to organize the electrical activity of the heart. If the pace pulses produce capture, cardioversion/defibrillation stimulation is delivered.

公开(公告)号：US20060134079A1

公开(公告)日：2006-06-22

申请号：US11017432

申请日：2004-12-20

申请人： Haris Sih ,  Joseph Pastore

发明人： Haris Sih ,  Joseph Pastore

IPC分类号： A61K48/00 ,  A61K38/19 ,  C12N5/08 ,  A61N1/00

CPC分类号： A61K38/30 ,  A61K35/545 ,  A61K38/18 ,  A61K38/1833 ,  A61K38/193 ,  A61K38/39 ,  A61K48/00 ,  A61N1/05 ,  A61N1/375

摘要： Implantable devices containing extracellular matrix and methods of using the devices are provided.

摘要翻译： 提供了含有细胞外基质的植入式装置和使用该装置的方法。